Risk of Colorectal Cancer for Carriers of Mutations in MUTYH , With and Without a Family History of Cancer

We studied 2332 individuals with monoallelic mutations in MUTYH among 9504 relatives of 264 colorectal cancer (CRC) cases with a MUTYH mutation. We estimated CRC risks through 70 years of age of 7.2% for male carriers of monoallelic mutations (95% confidence interval [CI], 4.6%–11.3%) and 5.6% for f...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2014-05, Vol.146 (5), p.1208-1211.e5
Hauptverfasser:	Win, Aung Ko, Dowty, James G, Cleary, Sean P, Kim, Hyeja, Buchanan, Daniel D, Young, Joanne P, Clendenning, Mark, Rosty, Christophe, MacInnis, Robert J, Giles, Graham G, Boussioutas, Alex, Macrae, Finlay A, Parry, Susan, Goldblatt, Jack, Baron, John A, Burnett, Terrilea, Le Marchand, Loïc, Newcomb, Polly A, Haile, Robert W, Hopper, John L, Cotterchio, Michelle, Gallinger, Steven, Lindor, Noralane M, Tucker, Katherine M, Winship, Ingrid M, Jenkins, Mark A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Australia Base Excision Repair Gene Colon Cancer Colorectal Neoplasms - genetics DNA Damage Response DNA Glycosylases - genetics Female Gastroenterology and Hepatology Genetic Predisposition to Disease Genetics Heredity Heterozygote Humans Male Middle Aged Mutation New Zealand North America Pedigree Phenotype Registries Risk Assessment Risk Factors
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