Discovery of protective B‐cell epitopes for development of antimicrobial vaccines and antibody therapeutics

Summary Protective antibodies play an essential role in immunity to infection by neutralizing microbes or their toxins and recruiting microbicidal effector functions. Identification of the protective B‐cell epitopes, those parts of microbial antigens that contact the variable regions of the protecti...

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Veröffentlicht in:	Immunology 2014-05, Vol.142 (1), p.1-23
Hauptverfasser:	Sharon, Jacqueline, Rynkiewicz, Michael J., Lu, Zhaohua, Yang, Chiou‐Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antibodies Antibodies, Bacterial - immunology Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Antibodies, Neutralizing - immunology Antibodies, Neutralizing - therapeutic use Antibodies, Viral - immunology Antigen-Antibody Reactions Antigens Antigens, Bacterial - chemistry Antigens, Bacterial - immunology Antigens, Viral - chemistry Antigens, Viral - immunology antigens/peptides/epitopes Bacterial Vaccines - immunology Bacterial Vaccines - therapeutic use Epitope Mapping Epitopes, B-Lymphocyte - chemistry Epitopes, B-Lymphocyte - immunology Francisella tularensis human Human immunodeficiency virus Humans Influenza virus Models, Molecular Protein Conformation Review structural biology/crystallography Vaccines Viral Vaccines - immunology Viral Vaccines - therapeutic use
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