Systematic identification of trans eQTLs as putative drivers of known disease associations

Lude Franke and colleagues report the results of a large expression QTL study performed on peripheral blood samples from 5,311 individuals. They identify trans -eQTL effects for 103 independent loci that were previously associated with complex traits at genome-wide significance, suggesting that this...

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Veröffentlicht in:	Nature genetics 2013-10, Vol.45 (10), p.1238-1243
Hauptverfasser:	Westra, Harm-Jan, Peters, Marjolein J, Esko, Tõnu, Yaghootkar, Hanieh, Schurmann, Claudia, Kettunen, Johannes, Christiansen, Mark W, Fairfax, Benjamin P, Schramm, Katharina, Powell, Joseph E, Zhernakova, Alexandra, Zhernakova, Daria V, Veldink, Jan H, Van den Berg, Leonard H, Karjalainen, Juha, Withoff, Sebo, Uitterlinden, André G, Hofman, Albert, Rivadeneira, Fernando, 't Hoen, Peter A C, Reinmaa, Eva, Fischer, Krista, Nelis, Mari, Milani, Lili, Melzer, David, Ferrucci, Luigi, Singleton, Andrew B, Hernandez, Dena G, Nalls, Michael A, Homuth, Georg, Nauck, Matthias, Radke, Dörte, Völker, Uwe, Perola, Markus, Salomaa, Veikko, Brody, Jennifer, Suchy-Dicey, Astrid, Gharib, Sina A, Enquobahrie, Daniel A, Lumley, Thomas, Montgomery, Grant W, Makino, Seiko, Prokisch, Holger, Herder, Christian, Roden, Michael, Grallert, Harald, Meitinger, Thomas, Strauch, Konstantin, Li, Yang, Jansen, Ritsert C, Visscher, Peter M, Knight, Julian C, Psaty, Bruce M, Ripatti, Samuli, Teumer, Alexander, Frayling, Timothy M, Metspalu, Andres, van Meurs, Joyce B J, Franke, Lude
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/191/2018 631/208/200 631/208/205 Agriculture Animal Genetics and Genomics Binding sites Biomedicine Cancer Research Diabetes Mellitus, Type 1 - genetics Disease Gene expression Gene Function Gene mapping Genetic aspects Genetic Predisposition to Disease Genomes Human Genetics Humans Identification and classification letter Lupus Erythematosus, Systemic - genetics Meta-analysis Polymorphism, Single Nucleotide Quantitative Trait Loci Single nucleotide polymorphisms Studies Systemic lupus erythematosus
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