Expression of monocyte chemotactic protein-1/CCL2 in gastric cancer and its relationship with tumor hypoxia
AIM:To investigate the expression and prognostic value of CCL2 in gastric cancer,as well as its relationshipwith tumor hypoxia.METHODS:Tumor tissues from 68 gastric cancer patients(GC)were analyzed,and the expression of CCL2and hypoxia-inducible factor 1 alpha(HIF-1α)in tumortissues was detected by...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2014-04, Vol.20 (15), p.4421-4427 |
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| creator | Tao, Lei-Lei Shi, Shu-Jing Chen, Long-Bang Huang, Gui-Chun |
| description | AIM:To investigate the expression and prognostic value of CCL2 in gastric cancer,as well as its relationshipwith tumor hypoxia.METHODS:Tumor tissues from 68 gastric cancer patients(GC)were analyzed,and the expression of CCL2and hypoxia-inducible factor 1 alpha(HIF-1α)in tumortissues was detected by immunohistochemistry.Statistical evaluations that were used included univariate logrank tests of Kaplan-Meier curves and multivariate Coxregression model analysis.RESULTS:CCL2 was highly expressed in 66.2%(45/68)of gastric cancer specimens.The distribution of CCL2expression in tumor tissue was consistent with thatof HIF-1α.Patients with high CCL2 expression in GChad a lower overall survival rate[50.6 mo(95%CI:44.44-56.93)vs 64.6 mo(95%CI:60.27-68.94),P=0.013].CONCLUSION:CCL2 expression correlates closely with HIF-1αexpression in gastric cancer.CCL2 may be an independent prognostic marker for GC. |
| doi_str_mv | 10.3748/wjg.v20.i15.4421 |
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All rights reserved. 2014</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-c3fb7189ff146e825f559dabe428c3403d336e0593a3930b80bed4061c6cc0be3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989980/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989980/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24764682$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tao, Lei-Lei</creatorcontrib><creatorcontrib>Shi, Shu-Jing</creatorcontrib><creatorcontrib>Chen, Long-Bang</creatorcontrib><creatorcontrib>Huang, Gui-Chun</creatorcontrib><title>Expression of monocyte chemotactic protein-1/CCL2 in gastric cancer and its relationship with tumor hypoxia</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM:To investigate the expression and prognostic value of CCL2 in gastric cancer,as well as its relationshipwith tumor hypoxia.METHODS:Tumor tissues from 68 gastric cancer patients(GC)were analyzed,and the expression of CCL2and hypoxia-inducible factor 1 alpha(HIF-1α)in tumortissues was detected by immunohistochemistry.Statistical evaluations that were used included univariate logrank tests of Kaplan-Meier curves and multivariate Coxregression model analysis.RESULTS:CCL2 was highly expressed in 66.2%(45/68)of gastric cancer specimens.The distribution of CCL2expression in tumor tissue was consistent with thatof HIF-1α.Patients with high CCL2 expression in GChad a lower overall survival rate[50.6 mo(95%CI:44.44-56.93)vs 64.6 mo(95%CI:60.27-68.94),P=0.013].CONCLUSION:CCL2 expression correlates closely with HIF-1αexpression in gastric cancer.CCL2 may be an independent prognostic marker for GC.</description><subject>Adult</subject><subject>Aged</subject><subject>Carcinoma - metabolism</subject><subject>Chemokine CCL2 - metabolism</subject><subject>Chemokines</subject><subject>chemotactic</subject><subject>Female</subject><subject>Gas</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Hypoxia-Inducible Factor 1, alpha Subunit - metabolism</subject><subject>Immunohistochemistry</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Monocyte</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>protein-1/CCL2</subject><subject>Research Report</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Treatment Outcome</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtr3DAURkVpaKZJ9l0FLbvxRE9b2gTCkD5goJtmLWRZtpXYkiNpksy_r4ZMh1YgJLjfPffCAeALRmvaMHHz-jisXwhaO8zXjBH8AawIwbIigqGPYIURaipJSXMOPqf0iBChlJNP4Jywpma1ICvwdP-2RJuSCx6GHs7BB7PPFprRziFrk52BSwzZOl_hm81mS6DzcNApx1Ix2hsbofYddDnBaCedCymNboGvLo8w7-YQ4bhfwpvTl-Cs11OyV8f3Ajx8u_-9-VFtf33_ubnbVoaJJleG9m2Dhex7zGorCO85l51uLSPCUIZoR2ltEZdUU0lRK1BrO4ZqbGpjyp9egNt37rJrZ9sZ63PUk1qim3Xcq6Cd-r_i3aiG8KKoFFIKVABfj4AYnnc2ZTW7ZOw0aW_DLinMsSR1WYWXKHqPmhhSirY_jcFIHRyp4kgVR6o4UgdHpeX63_VODX-llAA9Msfgh2fnh1NGInE4kiMmmOSkXMoEx5zQP_yTn_c</recordid><startdate>20140421</startdate><enddate>20140421</enddate><creator>Tao, Lei-Lei</creator><creator>Shi, Shu-Jing</creator><creator>Chen, Long-Bang</creator><creator>Huang, Gui-Chun</creator><general>Baishideng Publishing Group Co., Limited</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140421</creationdate><title>Expression of monocyte chemotactic protein-1/CCL2 in gastric cancer and its relationship with tumor hypoxia</title><author>Tao, Lei-Lei ; Shi, Shu-Jing ; Chen, Long-Bang ; Huang, Gui-Chun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-c3fb7189ff146e825f559dabe428c3403d336e0593a3930b80bed4061c6cc0be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Carcinoma - metabolism</topic><topic>Chemokine CCL2 - metabolism</topic><topic>Chemokines</topic><topic>chemotactic</topic><topic>Female</topic><topic>Gas</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Hypoxia-Inducible Factor 1, alpha Subunit - metabolism</topic><topic>Immunohistochemistry</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Monocyte</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>protein-1/CCL2</topic><topic>Research Report</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Treatment Outcome</topic><toplevel>online_resources</toplevel><creatorcontrib>Tao, Lei-Lei</creatorcontrib><creatorcontrib>Shi, Shu-Jing</creatorcontrib><creatorcontrib>Chen, Long-Bang</creatorcontrib><creatorcontrib>Huang, Gui-Chun</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tao, Lei-Lei</au><au>Shi, Shu-Jing</au><au>Chen, Long-Bang</au><au>Huang, Gui-Chun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of monocyte chemotactic protein-1/CCL2 in gastric cancer and its relationship with tumor hypoxia</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2014-04-21</date><risdate>2014</risdate><volume>20</volume><issue>15</issue><spage>4421</spage><epage>4427</epage><pages>4421-4427</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM:To investigate the expression and prognostic value of CCL2 in gastric cancer,as well as its relationshipwith tumor hypoxia.METHODS:Tumor tissues from 68 gastric cancer patients(GC)were analyzed,and the expression of CCL2and hypoxia-inducible factor 1 alpha(HIF-1α)in tumortissues was detected by immunohistochemistry.Statistical evaluations that were used included univariate logrank tests of Kaplan-Meier curves and multivariate Coxregression model analysis.RESULTS:CCL2 was highly expressed in 66.2%(45/68)of gastric cancer specimens.The distribution of CCL2expression in tumor tissue was consistent with thatof HIF-1α.Patients with high CCL2 expression in GChad a lower overall survival rate[50.6 mo(95%CI:44.44-56.93)vs 64.6 mo(95%CI:60.27-68.94),P=0.013].CONCLUSION:CCL2 expression correlates closely with HIF-1αexpression in gastric cancer.CCL2 may be an independent prognostic marker for GC.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Co., Limited</pub><pmid>24764682</pmid><doi>10.3748/wjg.v20.i15.4421</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Baishideng "World Journal of" online journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Aged Carcinoma - metabolism Chemokine CCL2 - metabolism Chemokines chemotactic Female Gas Gene Expression Regulation, Neoplastic Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Immunohistochemistry Kaplan-Meier Estimate Male Middle Aged Monocyte Prognosis Proportional Hazards Models protein-1/CCL2 Research Report Stomach Neoplasms - metabolism Treatment Outcome |
| title | Expression of monocyte chemotactic protein-1/CCL2 in gastric cancer and its relationship with tumor hypoxia |
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