Structural Basis of Substrate Recognition in Human Nicotinamide N-Methyltransferase

Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide, pyridines, and other analogues using S-adenosyl-l-methionine as donor. NNMT plays a significant role in the regulation of metabolic pathways and is expressed at markedly high levels in several kinds of cancers, pres...

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Veröffentlicht in:	Biochemistry (Easton) 2011-09, Vol.50 (36), p.7800-7808
Hauptverfasser:	Peng, Yi, Sartini, Davide, Pozzi, Valentina, Wilk, Dennis, Emanuelli, Monica, Yee, Vivien C
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES AMIDES AROMATICS BASIC BIOLOGICAL SCIENCES Binding Sites BIOLOGICAL PATHWAYS CATALYSIS CRYSTAL STRUCTURE ENZYME ACTIVITY ENZYMES FUNCTIONALS Humans KINETICS Models, Molecular Molecular Dynamics Simulation MUTAGENESIS MUTANTS NEOPLASMS Niacinamide - chemistry Niacinamide - metabolism NICOTINAMIDE Nicotinamide N-Methyltransferase - chemistry Nicotinamide N-Methyltransferase - metabolism Protein Conformation PYRIDINES REGULATIONS RESIDUES RESOLUTION S-Adenosylmethionine - chemistry Structure-Activity Relationship SUBSTRATES TARGETS THERAPY
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