S-Glutathionylation of Cryptic Cysteines Enhances Titin Elasticity by Blocking Protein Folding

The giant elastic protein titin is a determinant factor in how much blood fills the left ventricle during diastole and thus in the etiology of heart disease. Titin has been identified as a target of S-glutathionylation, an end product of the nitric-oxide-signaling cascade that increases cardiac musc...

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