Suppression of inflammatory cell trafficking and alveolar simplification by the heme oxygenase-1 product carbon monoxide

Bronchopulmonary dysplasia (BPD), a lung disease of prematurely born infants, is characterized in part by arrested development of pulmonary alveolae. We hypothesized that heme oxygenase (HO-1) and its byproduct carbon monoxide (CO), which are thought to be cytoprotective against redox stress, mitiga...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2014-04, Vol.306 (8), p.L749-L763
Hauptverfasser:	Anyanwu, Anuli C, Bentley, J Kelley, Popova, Antonia P, Malas, Omar, Alghanem, Husam, Goldsmith, Adam M, Hershenson, Marc B, Pinsky, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Antimetabolites - pharmacology Blotting, Western Carbon Monoxide - pharmacology Cells, Cultured Chemokine CCL2 - physiology Chemokines - genetics Chemokines - metabolism Cytokines Cytokines - genetics Cytokines - metabolism Female Flow Cytometry Fluorescent Antibody Technique Gene expression Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism Hyperoxia Hyperoxia - drug therapy Hyperoxia - physiopathology Immunoenzyme Techniques Lung diseases Macrophages, Alveolar Mice Mice, Inbred C57BL Mice, Knockout Monocytes Oxygen - metabolism Pneumonia - drug therapy Pneumonia - metabolism Pneumonia - pathology Proteins Pulmonary Alveoli - drug effects Pulmonary Alveoli - metabolism Pulmonary Alveoli - pathology Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Rodents
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