Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control

Mitochondrial dysfunction has long been associated with Parkinson's disease (PD). Parkin and PINK1 , two genes associated with familial PD, have been implicated in the degradation of depolarized mitochondria via autophagy (mitophagy). Here, we describe the involvement of parkin and PINK1 in a v...

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Veröffentlicht in:	The EMBO journal 2014-02, Vol.33 (4), p.282-295
Hauptverfasser:	McLelland, Gian-Luca, Soubannier, Vincent, Chen, Carol X, McBride, Heidi M, Fon, Edward A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimycin A - pharmacology Autophagy Autophagy - physiology Biological Transport EMBO20 Genes, Reporter GTP Phosphohydrolases - antagonists & inhibitors GTP Phosphohydrolases - genetics HeLa Cells Humans Lysosomes - physiology MDV Microtubule-Associated Proteins - antagonists & inhibitors Microtubule-Associated Proteins - genetics Mitochondria Mitochondria - physiology Mitochondrial DNA Mitochondrial Proteins - antagonists & inhibitors Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism mitophagy Models, Biological Oxidation-Reduction Oxidative Stress Parkin Parkinson Disease - genetics Parkinson Disease - metabolism Parkinson's disease PINK1 Protein Kinases - physiology Proteins Proteolysis Quality control Recombinant Fusion Proteins - metabolism RNA Interference RNA, Small Interfering - pharmacology Transport Vesicles - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - physiology
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