Gene Expression Profiling of the Leading Edge of Cutaneous Squamous Cell Carcinoma: IL-24-Driven MMP-7

The precise mechanisms governing invasion at the leading edge of squamous cell carcinoma (SCC) and its subsequent metastasis are not fully understood. We aimed to define the cancer-related molecular changes that distinguish noninvasive tumor from invasive SCC. To this end, we combined laser capture...

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Veröffentlicht in:	Journal of investigative dermatology 2014-05, Vol.134 (5), p.1418-1427
Hauptverfasser:	Mitsui, Hiroshi, Suárez-Fariñas, Mayte, Gulati, Nicholas, Shah, Kejal R., Cannizzaro, Maria V., Coats, Israel, Felsen, Diane, Krueger, James G., Carucci, John A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged, 80 and over Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Line, Tumor Cell Movement - genetics Disease Progression Female Gene Expression Regulation, Neoplastic - physiology Humans Interleukins - genetics Interleukins - metabolism Matrix Metalloproteinase 7 - genetics Matrix Metalloproteinase 7 - metabolism Middle Aged Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Oligonucleotide Array Sequence Analysis Skin Neoplasms - genetics Skin Neoplasms - metabolism Skin Neoplasms - pathology Transcriptome
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