Connexins: Mechanisms regulating protein levels and intercellular communication
Intercellular communication can occur through gap junction channels, which are comprised of connexin proteins. Therefore, levels of connexins can directly correlate with gap junctional intercellular communication. Because gap junctions have a critical role in maintaining cellular homeostasis, the re...
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| Veröffentlicht in: | FEBS letters 2014-04, Vol.588 (8), p.1212-1220 |
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| description | Intercellular communication can occur through gap junction channels, which are comprised of connexin proteins. Therefore, levels of connexins can directly correlate with gap junctional intercellular communication. Because gap junctions have a critical role in maintaining cellular homeostasis, the regulation of connexin protein levels is important. In the connexin life cycle, connexin protein levels can be modified through differential gene transcription or altered through trafficking and degradation mechanisms. More recently, significant attention has been directed to the pathways that cells utilize to increase or decrease connexin levels and thus indirectly, gap junctional communication. Here, we review the studies revealing the mechanisms that affect connexin protein levels and gap junctional intercellular communication. |
| doi_str_mv | 10.1016/j.febslet.2014.01.013 |
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Therefore, levels of connexins can directly correlate with gap junctional intercellular communication. Because gap junctions have a critical role in maintaining cellular homeostasis, the regulation of connexin protein levels is important. In the connexin life cycle, connexin protein levels can be modified through differential gene transcription or altered through trafficking and degradation mechanisms. More recently, significant attention has been directed to the pathways that cells utilize to increase or decrease connexin levels and thus indirectly, gap junctional communication. Here, we review the studies revealing the mechanisms that affect connexin protein levels and gap junctional intercellular communication.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/j.febslet.2014.01.013</identifier><identifier>PMID: 24457202</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>12-O-tetradecanoylphorbol 13-acetate ; AGJ ; Animals ; annular gap junctions ; Autophagy ; Cell Communication ; clathrin-mediated endocytosis ; CME ; Connexin ; connexin43 ; connexins ; Connexins - genetics ; Connexins - metabolism ; Cx43 ; Degradation ; EGF ; Endocytosis ; endoplasmic reticulum ; Endoplasmic Reticulum-Associated Degradation ; endosomal sorting complex required for transport ; epidermal growth factor ; ER-associated degradation ; ERAD ; ESCRT ; gap junctional intercellular communication ; gap junctions ; GJIC ; homeostasis ; Humans ; Intercellular Junctions - metabolism ; Lysosome ; Proteasome ; Proteolysis ; Secretory Pathway ; TPA ; Trafficking ; transcription (genetics) ; UBA ; ubiquitin interacting motif ; ubiquitin-associated domain ; ubiquitin-like domain ; Ubiquitins - metabolism ; UbL ; UIM</subject><ispartof>FEBS letters, 2014-04, Vol.588 (8), p.1212-1220</ispartof><rights>2014 Federation of European Biochemical Societies</rights><rights>FEBS Letters 588 (2014) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.</rights><rights>2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6318-b34b4c30475be74324ad3c11fbde2ccd3de2a277549fd0890cc4669ac30ec3b43</citedby><cites>FETCH-LOGICAL-c6318-b34b4c30475be74324ad3c11fbde2ccd3de2a277549fd0890cc4669ac30ec3b43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.febslet.2014.01.013$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014579314000398$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,3536,27903,27904,45553,45554,46387,46811,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24457202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Su, Vivian</creatorcontrib><creatorcontrib>Lau, Alan F.</creatorcontrib><title>Connexins: Mechanisms regulating protein levels and intercellular communication</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Intercellular communication can occur through gap junction channels, which are comprised of connexin proteins. Therefore, levels of connexins can directly correlate with gap junctional intercellular communication. Because gap junctions have a critical role in maintaining cellular homeostasis, the regulation of connexin protein levels is important. In the connexin life cycle, connexin protein levels can be modified through differential gene transcription or altered through trafficking and degradation mechanisms. More recently, significant attention has been directed to the pathways that cells utilize to increase or decrease connexin levels and thus indirectly, gap junctional communication. Here, we review the studies revealing the mechanisms that affect connexin protein levels and gap junctional intercellular communication.</description><subject>12-O-tetradecanoylphorbol 13-acetate</subject><subject>AGJ</subject><subject>Animals</subject><subject>annular gap junctions</subject><subject>Autophagy</subject><subject>Cell Communication</subject><subject>clathrin-mediated endocytosis</subject><subject>CME</subject><subject>Connexin</subject><subject>connexin43</subject><subject>connexins</subject><subject>Connexins - genetics</subject><subject>Connexins - metabolism</subject><subject>Cx43</subject><subject>Degradation</subject><subject>EGF</subject><subject>Endocytosis</subject><subject>endoplasmic reticulum</subject><subject>Endoplasmic Reticulum-Associated Degradation</subject><subject>endosomal sorting complex required for transport</subject><subject>epidermal growth factor</subject><subject>ER-associated degradation</subject><subject>ERAD</subject><subject>ESCRT</subject><subject>gap junctional intercellular communication</subject><subject>gap junctions</subject><subject>GJIC</subject><subject>homeostasis</subject><subject>Humans</subject><subject>Intercellular Junctions - metabolism</subject><subject>Lysosome</subject><subject>Proteasome</subject><subject>Proteolysis</subject><subject>Secretory Pathway</subject><subject>TPA</subject><subject>Trafficking</subject><subject>transcription (genetics)</subject><subject>UBA</subject><subject>ubiquitin interacting motif</subject><subject>ubiquitin-associated domain</subject><subject>ubiquitin-like domain</subject><subject>Ubiquitins - metabolism</subject><subject>UbL</subject><subject>UIM</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUk1P3DAQtVARLLQ_AZRjL9n6K3HCgYqu-KgE4kB7thxnsnjl2Fs72ZZ_X4fdonICaaTRaN48zZs3CJ0QPCeYlF9W8w6aaGGYU0z4HJMUbA_NSCVYznhZfUAznDp5IWp2iI5iXOFUV6Q-QIeU80JQTGfofuGdgz_GxbPsDvSjcib2MQuwHK0ajFtm6-AHMC6zsAEbM-XazLgBggZrEyZk2vf96IxOcO8-ov1O2QifdvkY_by6_LG4yW_vr78vLm5zXTJS5Q3jDdcMc1E0IDijXLVME9I1LVCtW5aSokIUvO5aXNVYa16WtUojoFnD2TE63_Kux6aHVoMbgrJyHUyvwpP0ysjXHWce5dJvJKurmlORCD7vCIL_NUIcZG_ipEk58GOU9Pla6VzFm1BS0FIwVuAqQYstVAcfY4DuZSOC5eSbXMmdb3LyTWKSgqW50__lvEz9MyoBbraA38bC0_tY5dXlN_owPcH0A4QnRUl9ovq6pUp2wsZAkFEbcBpaE0APsvXmjW3_AtKzw6U</recordid><startdate>20140417</startdate><enddate>20140417</enddate><creator>Su, Vivian</creator><creator>Lau, Alan F.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20140417</creationdate><title>Connexins: Mechanisms regulating protein levels and intercellular communication</title><author>Su, Vivian ; Lau, Alan F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6318-b34b4c30475be74324ad3c11fbde2ccd3de2a277549fd0890cc4669ac30ec3b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>12-O-tetradecanoylphorbol 13-acetate</topic><topic>AGJ</topic><topic>Animals</topic><topic>annular gap junctions</topic><topic>Autophagy</topic><topic>Cell Communication</topic><topic>clathrin-mediated endocytosis</topic><topic>CME</topic><topic>Connexin</topic><topic>connexin43</topic><topic>connexins</topic><topic>Connexins - genetics</topic><topic>Connexins - metabolism</topic><topic>Cx43</topic><topic>Degradation</topic><topic>EGF</topic><topic>Endocytosis</topic><topic>endoplasmic reticulum</topic><topic>Endoplasmic Reticulum-Associated Degradation</topic><topic>endosomal sorting complex required for transport</topic><topic>epidermal growth factor</topic><topic>ER-associated degradation</topic><topic>ERAD</topic><topic>ESCRT</topic><topic>gap junctional intercellular communication</topic><topic>gap junctions</topic><topic>GJIC</topic><topic>homeostasis</topic><topic>Humans</topic><topic>Intercellular Junctions - metabolism</topic><topic>Lysosome</topic><topic>Proteasome</topic><topic>Proteolysis</topic><topic>Secretory Pathway</topic><topic>TPA</topic><topic>Trafficking</topic><topic>transcription (genetics)</topic><topic>UBA</topic><topic>ubiquitin interacting motif</topic><topic>ubiquitin-associated domain</topic><topic>ubiquitin-like domain</topic><topic>Ubiquitins - metabolism</topic><topic>UbL</topic><topic>UIM</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Su, Vivian</creatorcontrib><creatorcontrib>Lau, Alan F.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Su, Vivian</au><au>Lau, Alan F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Connexins: Mechanisms regulating protein levels and intercellular communication</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2014-04-17</date><risdate>2014</risdate><volume>588</volume><issue>8</issue><spage>1212</spage><epage>1220</epage><pages>1212-1220</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>Intercellular communication can occur through gap junction channels, which are comprised of connexin proteins. 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; Alma/SFX Local Collection |
| subjects | 12-O-tetradecanoylphorbol 13-acetate AGJ Animals annular gap junctions Autophagy Cell Communication clathrin-mediated endocytosis CME Connexin connexin43 connexins Connexins - genetics Connexins - metabolism Cx43 Degradation EGF Endocytosis endoplasmic reticulum Endoplasmic Reticulum-Associated Degradation endosomal sorting complex required for transport epidermal growth factor ER-associated degradation ERAD ESCRT gap junctional intercellular communication gap junctions GJIC homeostasis Humans Intercellular Junctions - metabolism Lysosome Proteasome Proteolysis Secretory Pathway TPA Trafficking transcription (genetics) UBA ubiquitin interacting motif ubiquitin-associated domain ubiquitin-like domain Ubiquitins - metabolism UbL UIM |
| title | Connexins: Mechanisms regulating protein levels and intercellular communication |
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