Gene silencing associated with SWI/SNF complex loss during NSCLC development

The SWI/SNF chromatin-remodeling complex regulates gene expression and alters chromatin structures in an ATP-dependent manner. Recent sequencing efforts have shown mutations in BRG1 (SMARCA4), one of two mutually exclusive ATPase subunits in the complex, in a significant number of human lung tumor c...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular cancer research 2014-04, Vol.12 (4), p.560-570
Hauptverfasser:	Song, Shujie, Walter, Vonn, Karaca, Mehmet, Li, Ying, Bartlett, Christopher S, Smiraglia, Dominic J, Serber, Daniel, Sproul, Christopher D, Plass, Christoph, Zhang, Jiren, Hayes, D Neil, Zheng, Yanfang, Weissman, Bernard E
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell Line, Tumor Chromosomal Proteins, Non-Histone - deficiency Chromosomal Proteins, Non-Histone - genetics Disease Progression DNA Helicases - biosynthesis DNA Helicases - deficiency DNA Helicases - genetics DNA Methylation Gene Expression Gene Expression Regulation, Neoplastic Gene Silencing Genomics Humans Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Nuclear Proteins - biosynthesis Nuclear Proteins - deficiency Nuclear Proteins - genetics Promoter Regions, Genetic Tissue Array Analysis Transcription Factors - biosynthesis Transcription Factors - deficiency Transcription Factors - genetics Transfection
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!