Aerobic Exercise and Weight Loss Reduce Vascular Markers of Inflammation and Improve Insulin Sensitivity in Obese Women
Objectives To examine the relationships between plasma and tissue markers of systemic and vascular inflammation and obesity and insulin resistance and determine the effects of aerobic exercise training plus weight loss (AEX+WL) and weight loss (WL) alone on these biomarkers. Design Prospective contr...
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| Veröffentlicht in: | Journal of the American Geriatrics Society (JAGS) 2014-04, Vol.62 (4), p.607-614 |
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| container_title | Journal of the American Geriatrics Society (JAGS) |
| container_volume | 62 |
| creator | Ryan, Alice S. Ge, Shealinna Blumenthal, Jacob B. Serra, Monica C. Prior, Steven J. Goldberg, Andrew P. |
| description | Objectives
To examine the relationships between plasma and tissue markers of systemic and vascular inflammation and obesity and insulin resistance and determine the effects of aerobic exercise training plus weight loss (AEX+WL) and weight loss (WL) alone on these biomarkers.
Design
Prospective controlled study.
Setting
Veterans Affairs Medical Center and University research setting.
Participants
Overweight and obese sedentary postmenopausal women (N = 77).
Interventions
Six months, 3 d/wk AEX+WL (n = 37) or WL (n = 40).
Measurements
Total‐body dual‐energy X‐ray absorptiometry, abdominal computed tomography, hyperinsulinemic‐euglycemic clamps (a criterion standard method of assessing insulin sensitivity), adipose tissue biopsies (n = 28), and blood for homeostasis model assessment—insulin resistance, and soluble forms of intracellular adhesion molecule 1 (sICAM‐1) and vascular cell adhesion molecule 1 (sVCAM‐1), C‐reactive protein (CRP), and serum amyloid A (SAA).
Results
Body weight (P |
| doi_str_mv | 10.1111/jgs.12749 |
| format | Article |
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To examine the relationships between plasma and tissue markers of systemic and vascular inflammation and obesity and insulin resistance and determine the effects of aerobic exercise training plus weight loss (AEX+WL) and weight loss (WL) alone on these biomarkers.
Design
Prospective controlled study.
Setting
Veterans Affairs Medical Center and University research setting.
Participants
Overweight and obese sedentary postmenopausal women (N = 77).
Interventions
Six months, 3 d/wk AEX+WL (n = 37) or WL (n = 40).
Measurements
Total‐body dual‐energy X‐ray absorptiometry, abdominal computed tomography, hyperinsulinemic‐euglycemic clamps (a criterion standard method of assessing insulin sensitivity), adipose tissue biopsies (n = 28), and blood for homeostasis model assessment—insulin resistance, and soluble forms of intracellular adhesion molecule 1 (sICAM‐1) and vascular cell adhesion molecule 1 (sVCAM‐1), C‐reactive protein (CRP), and serum amyloid A (SAA).
Results
Body weight (P < .001), percentage of fat (P < .001), visceral fat (P < .005), triglyceride levels (P < .001), and systolic blood pressure decreased comparably after WL and AEX+WL (P = .04). Maximal oxygen consumption increased 16% after AEX+WL (P < .001). Insulin resistance decreased in both groups (P = .005). Glucose utilization according to the clamp increased 10% (P = .04) with AEX+WL and 8% with WL (P = .07). AEX+WL decreased CRP by 29% (P < .001) and WL by 21% (P = .02). SAA levels decreased twice as much after AEX+WL (−19%, P = .02) as after WL (−9%, P = .08). Plasma sICAM‐1 and sVCAM‐1 levels did not change, but women with the greatest reduction in plasma sICAM‐1 levels had the greatest reductions in fasting glucose (P = .02), insulin (P = .02), and insulin resistance (P = .004). Gluteal ICAM messenger ribonucleic acid levels decreased 27% after AEX+WL (P = .02) and did not change after WL.
Conclusion
Obesity and insulin resistance worsen markers of systemic and vascular inflammation. A reduction in plasma sICAM‐1 is important to improve insulin sensitivity. CRP, SAA, and tissue ICAM decrease with exercise and weight loss, suggesting that exercise training is a necessary component of lifestyle modification in obese postmenopausal women.]]></description><identifier>ISSN: 0002-8614</identifier><identifier>EISSN: 1532-5415</identifier><identifier>DOI: 10.1111/jgs.12749</identifier><identifier>PMID: 24635342</identifier><identifier>CODEN: JAGSAF</identifier><language>eng</language><publisher>Hoboken, NJ: Blackwell Publishing Ltd</publisher><subject>Absorptiometry, Photon ; Adipose Tissue - metabolism ; Aged ; Biological and medical sciences ; Biomarkers ; Biomarkers - metabolism ; Blood Glucose - metabolism ; Blood vessels ; Body Mass Index ; C-Reactive Protein - metabolism ; diet ; Exercise ; Exercise - physiology ; Exercise Therapy - methods ; Female ; Follow-Up Studies ; General aspects ; Humans ; inflammation ; Inflammation - metabolism ; Inflammation - physiopathology ; Inflammatory diseases ; Insulin resistance ; Insulin Resistance - physiology ; insulin sensitivity ; Intercellular Adhesion Molecule-1 - blood ; Medical sciences ; Metabolic diseases ; Middle Aged ; Miscellaneous ; Obesity ; Obesity - metabolism ; Obesity - physiopathology ; Obesity - rehabilitation ; Postmenopause ; Prognosis ; Prospective Studies ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Serum Amyloid A Protein - metabolism ; Vascular Cell Adhesion Molecule-1 - blood ; Weight control ; Weight Loss - physiology ; Womens health</subject><ispartof>Journal of the American Geriatrics Society (JAGS), 2014-04, Vol.62 (4), p.607-614</ispartof><rights>Published 2014. This article is a U.S. Government work and is in the public domain in the U.S.A.</rights><rights>2015 INIST-CNRS</rights><rights>2014 American Geriatrics Society and Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6109-82a4554408c3fe46b75cdab1935c00fbead74b2fde93c384c2698e739748b3163</citedby><cites>FETCH-LOGICAL-c6109-82a4554408c3fe46b75cdab1935c00fbead74b2fde93c384c2698e739748b3163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjgs.12749$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjgs.12749$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28475379$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24635342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ryan, Alice S.</creatorcontrib><creatorcontrib>Ge, Shealinna</creatorcontrib><creatorcontrib>Blumenthal, Jacob B.</creatorcontrib><creatorcontrib>Serra, Monica C.</creatorcontrib><creatorcontrib>Prior, Steven J.</creatorcontrib><creatorcontrib>Goldberg, Andrew P.</creatorcontrib><title>Aerobic Exercise and Weight Loss Reduce Vascular Markers of Inflammation and Improve Insulin Sensitivity in Obese Women</title><title>Journal of the American Geriatrics Society (JAGS)</title><addtitle>J Am Geriatr Soc</addtitle><description><![CDATA[Objectives
To examine the relationships between plasma and tissue markers of systemic and vascular inflammation and obesity and insulin resistance and determine the effects of aerobic exercise training plus weight loss (AEX+WL) and weight loss (WL) alone on these biomarkers.
Design
Prospective controlled study.
Setting
Veterans Affairs Medical Center and University research setting.
Participants
Overweight and obese sedentary postmenopausal women (N = 77).
Interventions
Six months, 3 d/wk AEX+WL (n = 37) or WL (n = 40).
Measurements
Total‐body dual‐energy X‐ray absorptiometry, abdominal computed tomography, hyperinsulinemic‐euglycemic clamps (a criterion standard method of assessing insulin sensitivity), adipose tissue biopsies (n = 28), and blood for homeostasis model assessment—insulin resistance, and soluble forms of intracellular adhesion molecule 1 (sICAM‐1) and vascular cell adhesion molecule 1 (sVCAM‐1), C‐reactive protein (CRP), and serum amyloid A (SAA).
Results
Body weight (P < .001), percentage of fat (P < .001), visceral fat (P < .005), triglyceride levels (P < .001), and systolic blood pressure decreased comparably after WL and AEX+WL (P = .04). Maximal oxygen consumption increased 16% after AEX+WL (P < .001). Insulin resistance decreased in both groups (P = .005). Glucose utilization according to the clamp increased 10% (P = .04) with AEX+WL and 8% with WL (P = .07). AEX+WL decreased CRP by 29% (P < .001) and WL by 21% (P = .02). SAA levels decreased twice as much after AEX+WL (−19%, P = .02) as after WL (−9%, P = .08). Plasma sICAM‐1 and sVCAM‐1 levels did not change, but women with the greatest reduction in plasma sICAM‐1 levels had the greatest reductions in fasting glucose (P = .02), insulin (P = .02), and insulin resistance (P = .004). Gluteal ICAM messenger ribonucleic acid levels decreased 27% after AEX+WL (P = .02) and did not change after WL.
Conclusion
Obesity and insulin resistance worsen markers of systemic and vascular inflammation. A reduction in plasma sICAM‐1 is important to improve insulin sensitivity. CRP, SAA, and tissue ICAM decrease with exercise and weight loss, suggesting that exercise training is a necessary component of lifestyle modification in obese postmenopausal women.]]></description><subject>Absorptiometry, Photon</subject><subject>Adipose Tissue - metabolism</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Blood Glucose - metabolism</subject><subject>Blood vessels</subject><subject>Body Mass Index</subject><subject>C-Reactive Protein - metabolism</subject><subject>diet</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Exercise Therapy - methods</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>Humans</subject><subject>inflammation</subject><subject>Inflammation - metabolism</subject><subject>Inflammation - physiopathology</subject><subject>Inflammatory diseases</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - physiology</subject><subject>insulin sensitivity</subject><subject>Intercellular Adhesion Molecule-1 - blood</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Obesity</subject><subject>Obesity - metabolism</subject><subject>Obesity - physiopathology</subject><subject>Obesity - rehabilitation</subject><subject>Postmenopause</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Serum Amyloid A Protein - metabolism</subject><subject>Vascular Cell Adhesion Molecule-1 - blood</subject><subject>Weight control</subject><subject>Weight Loss - physiology</subject><subject>Womens health</subject><issn>0002-8614</issn><issn>1532-5415</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkt9v0zAQgCMEYmXwwD-ALCEkeMhmx3YcvyCNbZSi0kkM6KPlOJfOJYmLnWzrf4-7duWHhPCLZd13d_Z9TpLnBB-RuI6Xi3BEMsHkg2REOM1Szgh_mIwwxlla5IQdJE9CWGJMMlwUj5ODjOWUU5aNkpsT8K60Bp3fgjc2ANJdheZgF1c9mroQ0GeoBgPomw5maLRHn7T_Dj4gV6NJVze6bXVvXXeXN2lX3l1DDIShsR26hC7Y3l7bfo3i8aKE2GDuWuieJo9q3QR4ttsPk6_vz7-cfkinF-PJ6ck0NTnBMi0yzThnDBeG1sDyUnBT6ZJIyg3GdQm6EqzM6gokNbRgJstlAYJKwYqSkpweJm-3dVdD2UJloOu9btTK21b7tXLaqj8jnb1SC3etqCwkwzIWeL0r4N2PAUKvWhsMNI3uwA1BkUIKKjIu8P9RTvJIMkkj-vIvdOkG38VJbCiey2hHROrNljI-mvBQ7-9NsNqYV9G8ujMf2Re_P3RP3quOwKsdEE3qpva6i75_cQUTnIpNoeMtd2MbWP-7o_o4vrxvnW4zbOjhdp8R_4nK42y4ms_GapbPzt6dMaIY_QmyDtQZ</recordid><startdate>201404</startdate><enddate>201404</enddate><creator>Ryan, Alice S.</creator><creator>Ge, Shealinna</creator><creator>Blumenthal, Jacob B.</creator><creator>Serra, Monica C.</creator><creator>Prior, Steven J.</creator><creator>Goldberg, Andrew P.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7TS</scope><scope>5PM</scope></search><sort><creationdate>201404</creationdate><title>Aerobic Exercise and Weight Loss Reduce Vascular Markers of Inflammation and Improve Insulin Sensitivity in Obese Women</title><author>Ryan, Alice S. ; Ge, Shealinna ; Blumenthal, Jacob B. ; Serra, Monica C. ; Prior, Steven J. ; Goldberg, Andrew P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6109-82a4554408c3fe46b75cdab1935c00fbead74b2fde93c384c2698e739748b3163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Absorptiometry, Photon</topic><topic>Adipose Tissue - metabolism</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Biomarkers - metabolism</topic><topic>Blood Glucose - metabolism</topic><topic>Blood vessels</topic><topic>Body Mass Index</topic><topic>C-Reactive Protein - metabolism</topic><topic>diet</topic><topic>Exercise</topic><topic>Exercise - physiology</topic><topic>Exercise Therapy - methods</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>General aspects</topic><topic>Humans</topic><topic>inflammation</topic><topic>Inflammation - metabolism</topic><topic>Inflammation - physiopathology</topic><topic>Inflammatory diseases</topic><topic>Insulin resistance</topic><topic>Insulin Resistance - physiology</topic><topic>insulin sensitivity</topic><topic>Intercellular Adhesion Molecule-1 - blood</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Obesity</topic><topic>Obesity - metabolism</topic><topic>Obesity - physiopathology</topic><topic>Obesity - rehabilitation</topic><topic>Postmenopause</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Serum Amyloid A Protein - metabolism</topic><topic>Vascular Cell Adhesion Molecule-1 - blood</topic><topic>Weight control</topic><topic>Weight Loss - physiology</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ryan, Alice S.</creatorcontrib><creatorcontrib>Ge, Shealinna</creatorcontrib><creatorcontrib>Blumenthal, Jacob B.</creatorcontrib><creatorcontrib>Serra, Monica C.</creatorcontrib><creatorcontrib>Prior, Steven J.</creatorcontrib><creatorcontrib>Goldberg, Andrew P.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Physical Education Index</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ryan, Alice S.</au><au>Ge, Shealinna</au><au>Blumenthal, Jacob B.</au><au>Serra, Monica C.</au><au>Prior, Steven J.</au><au>Goldberg, Andrew P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aerobic Exercise and Weight Loss Reduce Vascular Markers of Inflammation and Improve Insulin Sensitivity in Obese Women</atitle><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle><addtitle>J Am Geriatr Soc</addtitle><date>2014-04</date><risdate>2014</risdate><volume>62</volume><issue>4</issue><spage>607</spage><epage>614</epage><pages>607-614</pages><issn>0002-8614</issn><eissn>1532-5415</eissn><coden>JAGSAF</coden><abstract><![CDATA[Objectives
To examine the relationships between plasma and tissue markers of systemic and vascular inflammation and obesity and insulin resistance and determine the effects of aerobic exercise training plus weight loss (AEX+WL) and weight loss (WL) alone on these biomarkers.
Design
Prospective controlled study.
Setting
Veterans Affairs Medical Center and University research setting.
Participants
Overweight and obese sedentary postmenopausal women (N = 77).
Interventions
Six months, 3 d/wk AEX+WL (n = 37) or WL (n = 40).
Measurements
Total‐body dual‐energy X‐ray absorptiometry, abdominal computed tomography, hyperinsulinemic‐euglycemic clamps (a criterion standard method of assessing insulin sensitivity), adipose tissue biopsies (n = 28), and blood for homeostasis model assessment—insulin resistance, and soluble forms of intracellular adhesion molecule 1 (sICAM‐1) and vascular cell adhesion molecule 1 (sVCAM‐1), C‐reactive protein (CRP), and serum amyloid A (SAA).
Results
Body weight (P < .001), percentage of fat (P < .001), visceral fat (P < .005), triglyceride levels (P < .001), and systolic blood pressure decreased comparably after WL and AEX+WL (P = .04). Maximal oxygen consumption increased 16% after AEX+WL (P < .001). Insulin resistance decreased in both groups (P = .005). Glucose utilization according to the clamp increased 10% (P = .04) with AEX+WL and 8% with WL (P = .07). AEX+WL decreased CRP by 29% (P < .001) and WL by 21% (P = .02). SAA levels decreased twice as much after AEX+WL (−19%, P = .02) as after WL (−9%, P = .08). Plasma sICAM‐1 and sVCAM‐1 levels did not change, but women with the greatest reduction in plasma sICAM‐1 levels had the greatest reductions in fasting glucose (P = .02), insulin (P = .02), and insulin resistance (P = .004). Gluteal ICAM messenger ribonucleic acid levels decreased 27% after AEX+WL (P = .02) and did not change after WL.
Conclusion
Obesity and insulin resistance worsen markers of systemic and vascular inflammation. A reduction in plasma sICAM‐1 is important to improve insulin sensitivity. CRP, SAA, and tissue ICAM decrease with exercise and weight loss, suggesting that exercise training is a necessary component of lifestyle modification in obese postmenopausal women.]]></abstract><cop>Hoboken, NJ</cop><pub>Blackwell Publishing Ltd</pub><pmid>24635342</pmid><doi>10.1111/jgs.12749</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-8614 |
| ispartof | Journal of the American Geriatrics Society (JAGS), 2014-04, Vol.62 (4), p.607-614 |
| issn | 0002-8614 1532-5415 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3989409 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Absorptiometry, Photon Adipose Tissue - metabolism Aged Biological and medical sciences Biomarkers Biomarkers - metabolism Blood Glucose - metabolism Blood vessels Body Mass Index C-Reactive Protein - metabolism diet Exercise Exercise - physiology Exercise Therapy - methods Female Follow-Up Studies General aspects Humans inflammation Inflammation - metabolism Inflammation - physiopathology Inflammatory diseases Insulin resistance Insulin Resistance - physiology insulin sensitivity Intercellular Adhesion Molecule-1 - blood Medical sciences Metabolic diseases Middle Aged Miscellaneous Obesity Obesity - metabolism Obesity - physiopathology Obesity - rehabilitation Postmenopause Prognosis Prospective Studies Public health. Hygiene Public health. Hygiene-occupational medicine Serum Amyloid A Protein - metabolism Vascular Cell Adhesion Molecule-1 - blood Weight control Weight Loss - physiology Womens health |
| title | Aerobic Exercise and Weight Loss Reduce Vascular Markers of Inflammation and Improve Insulin Sensitivity in Obese Women |
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