The Centrosome-Specific Phosphorylation of Cnn by Polo/Plk1 Drives Cnn Scaffold Assembly and Centrosome Maturation

Centrosomes are important cell organizers. They consist of a pair of centrioles surrounded by pericentriolar material (PCM) that expands dramatically during mitosis—a process termed centrosome maturation. How centrosomes mature remains mysterious. Here, we identify a domain in Drosophila Cnn that ap...

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Veröffentlicht in:	Developmental cell 2014-03, Vol.28 (6), p.659-669
Hauptverfasser:	Conduit, Paul T., Feng, Zhe, Richens, Jennifer H., Baumbach, Janina, Wainman, Alan, Bakshi, Suruchi D., Dobbelaere, Jeroen, Johnson, Steven, Lea, Susan M., Raff, Jordan W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Animals, Genetically Modified Brain - cytology Brain - metabolism Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cells, Cultured Centrosome - metabolism Cytoplasm - metabolism Drosophila Drosophila melanogaster - genetics Drosophila melanogaster - growth & development Drosophila melanogaster - metabolism Drosophila Proteins - chemistry Drosophila Proteins - genetics Drosophila Proteins - metabolism Homeodomain Proteins - chemistry Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Image Processing, Computer-Assisted Immunoprecipitation Microtubules - metabolism Mitosis - physiology Molecular Sequence Data Phosphorylation Polo-Like Kinase 1 Protein Multimerization Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Sequence Homology, Amino Acid Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Two-Hybrid System Techniques
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