Angiotensin-converting enzyme genetic polymorphism: its impact on cardiac remodeling
The role of angiotensin-converting enzyme genetic polymorphisms as a predictor of echocardiographic outcomes on heart failure is yet to be established. The local profile should be identified so that the impact of those genotypes on the Brazilian population could be identified. This is the first stud...
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| Veröffentlicht in: | Arquivos brasileiros de cardiologia 2014-01, Vol.102 (1), p.70-79 |
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| creator | Albuquerque, Felipe Neves de Brandão, Andréa Araujo Silva, Dayse Aparecida da Mourilhe-Rocha, Ricardo Duque, Gustavo Salgado Gondar, Alyne Freitas Pereira Neves, Luiza Maceira de Almeida Bittencourt, Marcelo Imbroinise Pozzan, Roberto Albuquerque, Denilson Campos de |
| description | The role of angiotensin-converting enzyme genetic polymorphisms as a predictor of echocardiographic outcomes on heart failure is yet to be established. The local profile should be identified so that the impact of those genotypes on the Brazilian population could be identified. This is the first study on exclusively non-ischemic heart failure over a follow-up longer than 5 years.
To determine the distribution of angiotensin-converting enzyme genetic polymorphism variants and their relation with echocardiographic outcome of patients with non-ischemic heart failure.
Secondary analysis of the medical records of 111 patients and identification of the angiotensin-converting enzyme genetic polymorphism variants, classified as DD (Deletion/Deletion), DI (Deletion/Insertion) or II (Insertion/Insertion).
The cohort means were as follows: follow-up, 64.9 months; age, 59.5 years; male sex, 60.4%; white skin color, 51.4%; use of beta-blockers, 98.2%; and use of angiotensin-converting-enzyme inhibitors or angiotensin receptor blocker, 89.2%. The angiotensin-converting enzyme genetic polymorphism distribution was as follows: DD, 51.4%; DI, 44.1%; and II, 4.5%. No difference regarding the clinical characteristics or treatment was observed between the groups. The final left ventricular systolic diameter was the only isolated echocardiographic variable that significantly differed between the angiotensin-converting enzyme genetic polymorphisms: 59.2 ± 1.8 for DD versus 52.3 ± 1.9 for DI versus 59.2 ± 5.2 for II (p = 0.029). Considering the evolutionary behavior, all echocardiographic variables (difference between the left ventricular ejection fraction at the last and first consultation; difference between the left ventricular systolic diameter at the last and first consultation; and difference between the left ventricular diastolic diameter at the last and first consultation) differed between the genotypes (p = 0.024; p = 0.002; and p = 0.021, respectively).
The distribution of the angiotensin-converting enzyme genetic polymorphisms differed from that of other studies with a very small number of II. The DD genotype was independently associated with worse echocardiographic outcome, while the DI genotype, with the best echocardiographic profile (increased left ventricular ejection fraction and decreased left ventricular diameters). |
| doi_str_mv | 10.5935/abc.20130229 |
| format | Article |
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To determine the distribution of angiotensin-converting enzyme genetic polymorphism variants and their relation with echocardiographic outcome of patients with non-ischemic heart failure.
Secondary analysis of the medical records of 111 patients and identification of the angiotensin-converting enzyme genetic polymorphism variants, classified as DD (Deletion/Deletion), DI (Deletion/Insertion) or II (Insertion/Insertion).
The cohort means were as follows: follow-up, 64.9 months; age, 59.5 years; male sex, 60.4%; white skin color, 51.4%; use of beta-blockers, 98.2%; and use of angiotensin-converting-enzyme inhibitors or angiotensin receptor blocker, 89.2%. The angiotensin-converting enzyme genetic polymorphism distribution was as follows: DD, 51.4%; DI, 44.1%; and II, 4.5%. No difference regarding the clinical characteristics or treatment was observed between the groups. The final left ventricular systolic diameter was the only isolated echocardiographic variable that significantly differed between the angiotensin-converting enzyme genetic polymorphisms: 59.2 ± 1.8 for DD versus 52.3 ± 1.9 for DI versus 59.2 ± 5.2 for II (p = 0.029). Considering the evolutionary behavior, all echocardiographic variables (difference between the left ventricular ejection fraction at the last and first consultation; difference between the left ventricular systolic diameter at the last and first consultation; and difference between the left ventricular diastolic diameter at the last and first consultation) differed between the genotypes (p = 0.024; p = 0.002; and p = 0.021, respectively).
The distribution of the angiotensin-converting enzyme genetic polymorphisms differed from that of other studies with a very small number of II. The DD genotype was independently associated with worse echocardiographic outcome, while the DI genotype, with the best echocardiographic profile (increased left ventricular ejection fraction and decreased left ventricular diameters).</description><identifier>ISSN: 0066-782X</identifier><identifier>EISSN: 1678-4170</identifier><identifier>DOI: 10.5935/abc.20130229</identifier><identifier>PMID: 24270863</identifier><language>eng</language><publisher>Brazil: Sociedade Brasileira de Cardiologia</publisher><subject>Adult ; Aged, 80 and over ; Analysis of Variance ; Chi-Square Distribution ; Cohort Studies ; Female ; Follow-Up Studies ; Gene Deletion ; Genotype ; Heart Failure - diagnostic imaging ; Heart Failure - genetics ; Humans ; Male ; Middle Aged ; Original ; Peptidyl-Dipeptidase A - genetics ; Polymorphism, Genetic - genetics ; Stroke Volume - genetics ; Time Factors ; Ultrasonography ; Ventricular Remodeling - genetics</subject><ispartof>Arquivos brasileiros de cardiologia, 2014-01, Vol.102 (1), p.70-79</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c314t-f30b29cda38820ff67119f36d63b1ad283a2c16d89a9e0bb1bc6fe200353a2eb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987401/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987401/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24270863$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Albuquerque, Felipe Neves de</creatorcontrib><creatorcontrib>Brandão, Andréa Araujo</creatorcontrib><creatorcontrib>Silva, Dayse Aparecida da</creatorcontrib><creatorcontrib>Mourilhe-Rocha, Ricardo</creatorcontrib><creatorcontrib>Duque, Gustavo Salgado</creatorcontrib><creatorcontrib>Gondar, Alyne Freitas Pereira</creatorcontrib><creatorcontrib>Neves, Luiza Maceira de Almeida</creatorcontrib><creatorcontrib>Bittencourt, Marcelo Imbroinise</creatorcontrib><creatorcontrib>Pozzan, Roberto</creatorcontrib><creatorcontrib>Albuquerque, Denilson Campos de</creatorcontrib><title>Angiotensin-converting enzyme genetic polymorphism: its impact on cardiac remodeling</title><title>Arquivos brasileiros de cardiologia</title><addtitle>Arq Bras Cardiol</addtitle><description>The role of angiotensin-converting enzyme genetic polymorphisms as a predictor of echocardiographic outcomes on heart failure is yet to be established. The local profile should be identified so that the impact of those genotypes on the Brazilian population could be identified. This is the first study on exclusively non-ischemic heart failure over a follow-up longer than 5 years.
To determine the distribution of angiotensin-converting enzyme genetic polymorphism variants and their relation with echocardiographic outcome of patients with non-ischemic heart failure.
Secondary analysis of the medical records of 111 patients and identification of the angiotensin-converting enzyme genetic polymorphism variants, classified as DD (Deletion/Deletion), DI (Deletion/Insertion) or II (Insertion/Insertion).
The cohort means were as follows: follow-up, 64.9 months; age, 59.5 years; male sex, 60.4%; white skin color, 51.4%; use of beta-blockers, 98.2%; and use of angiotensin-converting-enzyme inhibitors or angiotensin receptor blocker, 89.2%. The angiotensin-converting enzyme genetic polymorphism distribution was as follows: DD, 51.4%; DI, 44.1%; and II, 4.5%. No difference regarding the clinical characteristics or treatment was observed between the groups. The final left ventricular systolic diameter was the only isolated echocardiographic variable that significantly differed between the angiotensin-converting enzyme genetic polymorphisms: 59.2 ± 1.8 for DD versus 52.3 ± 1.9 for DI versus 59.2 ± 5.2 for II (p = 0.029). Considering the evolutionary behavior, all echocardiographic variables (difference between the left ventricular ejection fraction at the last and first consultation; difference between the left ventricular systolic diameter at the last and first consultation; and difference between the left ventricular diastolic diameter at the last and first consultation) differed between the genotypes (p = 0.024; p = 0.002; and p = 0.021, respectively).
The distribution of the angiotensin-converting enzyme genetic polymorphisms differed from that of other studies with a very small number of II. The DD genotype was independently associated with worse echocardiographic outcome, while the DI genotype, with the best echocardiographic profile (increased left ventricular ejection fraction and decreased left ventricular diameters).</description><subject>Adult</subject><subject>Aged, 80 and over</subject><subject>Analysis of Variance</subject><subject>Chi-Square Distribution</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gene Deletion</subject><subject>Genotype</subject><subject>Heart Failure - diagnostic imaging</subject><subject>Heart Failure - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Peptidyl-Dipeptidase A - genetics</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Stroke Volume - genetics</subject><subject>Time Factors</subject><subject>Ultrasonography</subject><subject>Ventricular Remodeling - genetics</subject><issn>0066-782X</issn><issn>1678-4170</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkF1LwzAYhYMobk7vvJb8AKv5aNPUC2EMv2DgzQTvQpImXaRNSlIH89dbmRt69V6c55wXHgAuMbopKlrcSqVvCMIUEVIdgSlmJc9yXKJjMEWIsazk5H0CzlL6QCNS0uIUTEhOSsQZnYLV3DcuDMYn5zMd_MbEwfkGGv-17QxsjDeD07AP7bYLsV-71N1BNyToul7qAQYPtYy1kxpG04XatGP7HJxY2SZz8Xtn4O3xYbV4zpavTy-L-TLTFOdDZilSpNK1pJwTZC0rMa4sZTWjCsuacCqJxqzmlawMUgorzawhCNFiTIyiM3C_2-0_VWdqbfwQZSv66DoZtyJIJ_4n3q1FEzaCVrzMR2czcL0b0DGkFI09dDESP3bFaFfs7Y741d9_B3ivk34Dp4947Q</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Albuquerque, Felipe Neves de</creator><creator>Brandão, Andréa Araujo</creator><creator>Silva, Dayse Aparecida da</creator><creator>Mourilhe-Rocha, Ricardo</creator><creator>Duque, Gustavo Salgado</creator><creator>Gondar, Alyne Freitas Pereira</creator><creator>Neves, Luiza Maceira de Almeida</creator><creator>Bittencourt, Marcelo Imbroinise</creator><creator>Pozzan, Roberto</creator><creator>Albuquerque, Denilson Campos de</creator><general>Sociedade Brasileira de Cardiologia</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20140101</creationdate><title>Angiotensin-converting enzyme genetic polymorphism: its impact on cardiac remodeling</title><author>Albuquerque, Felipe Neves de ; Brandão, Andréa Araujo ; Silva, Dayse Aparecida da ; Mourilhe-Rocha, Ricardo ; Duque, Gustavo Salgado ; Gondar, Alyne Freitas Pereira ; Neves, Luiza Maceira de Almeida ; Bittencourt, Marcelo Imbroinise ; Pozzan, Roberto ; Albuquerque, Denilson Campos de</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c314t-f30b29cda38820ff67119f36d63b1ad283a2c16d89a9e0bb1bc6fe200353a2eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged, 80 and over</topic><topic>Analysis of Variance</topic><topic>Chi-Square Distribution</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gene Deletion</topic><topic>Genotype</topic><topic>Heart Failure - diagnostic imaging</topic><topic>Heart Failure - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Peptidyl-Dipeptidase A - genetics</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Stroke Volume - genetics</topic><topic>Time Factors</topic><topic>Ultrasonography</topic><topic>Ventricular Remodeling - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Albuquerque, Felipe Neves de</creatorcontrib><creatorcontrib>Brandão, Andréa Araujo</creatorcontrib><creatorcontrib>Silva, Dayse Aparecida da</creatorcontrib><creatorcontrib>Mourilhe-Rocha, Ricardo</creatorcontrib><creatorcontrib>Duque, Gustavo Salgado</creatorcontrib><creatorcontrib>Gondar, Alyne Freitas Pereira</creatorcontrib><creatorcontrib>Neves, Luiza Maceira de Almeida</creatorcontrib><creatorcontrib>Bittencourt, Marcelo Imbroinise</creatorcontrib><creatorcontrib>Pozzan, Roberto</creatorcontrib><creatorcontrib>Albuquerque, Denilson Campos de</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Arquivos brasileiros de cardiologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Albuquerque, Felipe Neves de</au><au>Brandão, Andréa Araujo</au><au>Silva, Dayse Aparecida da</au><au>Mourilhe-Rocha, Ricardo</au><au>Duque, Gustavo Salgado</au><au>Gondar, Alyne Freitas Pereira</au><au>Neves, Luiza Maceira de Almeida</au><au>Bittencourt, Marcelo Imbroinise</au><au>Pozzan, Roberto</au><au>Albuquerque, Denilson Campos de</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angiotensin-converting enzyme genetic polymorphism: its impact on cardiac remodeling</atitle><jtitle>Arquivos brasileiros de cardiologia</jtitle><addtitle>Arq Bras Cardiol</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>102</volume><issue>1</issue><spage>70</spage><epage>79</epage><pages>70-79</pages><issn>0066-782X</issn><eissn>1678-4170</eissn><abstract>The role of angiotensin-converting enzyme genetic polymorphisms as a predictor of echocardiographic outcomes on heart failure is yet to be established. The local profile should be identified so that the impact of those genotypes on the Brazilian population could be identified. This is the first study on exclusively non-ischemic heart failure over a follow-up longer than 5 years.
To determine the distribution of angiotensin-converting enzyme genetic polymorphism variants and their relation with echocardiographic outcome of patients with non-ischemic heart failure.
Secondary analysis of the medical records of 111 patients and identification of the angiotensin-converting enzyme genetic polymorphism variants, classified as DD (Deletion/Deletion), DI (Deletion/Insertion) or II (Insertion/Insertion).
The cohort means were as follows: follow-up, 64.9 months; age, 59.5 years; male sex, 60.4%; white skin color, 51.4%; use of beta-blockers, 98.2%; and use of angiotensin-converting-enzyme inhibitors or angiotensin receptor blocker, 89.2%. The angiotensin-converting enzyme genetic polymorphism distribution was as follows: DD, 51.4%; DI, 44.1%; and II, 4.5%. No difference regarding the clinical characteristics or treatment was observed between the groups. The final left ventricular systolic diameter was the only isolated echocardiographic variable that significantly differed between the angiotensin-converting enzyme genetic polymorphisms: 59.2 ± 1.8 for DD versus 52.3 ± 1.9 for DI versus 59.2 ± 5.2 for II (p = 0.029). Considering the evolutionary behavior, all echocardiographic variables (difference between the left ventricular ejection fraction at the last and first consultation; difference between the left ventricular systolic diameter at the last and first consultation; and difference between the left ventricular diastolic diameter at the last and first consultation) differed between the genotypes (p = 0.024; p = 0.002; and p = 0.021, respectively).
The distribution of the angiotensin-converting enzyme genetic polymorphisms differed from that of other studies with a very small number of II. The DD genotype was independently associated with worse echocardiographic outcome, while the DI genotype, with the best echocardiographic profile (increased left ventricular ejection fraction and decreased left ventricular diameters).</abstract><cop>Brazil</cop><pub>Sociedade Brasileira de Cardiologia</pub><pmid>24270863</pmid><doi>10.5935/abc.20130229</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged, 80 and over Analysis of Variance Chi-Square Distribution Cohort Studies Female Follow-Up Studies Gene Deletion Genotype Heart Failure - diagnostic imaging Heart Failure - genetics Humans Male Middle Aged Original Peptidyl-Dipeptidase A - genetics Polymorphism, Genetic - genetics Stroke Volume - genetics Time Factors Ultrasonography Ventricular Remodeling - genetics |
| title | Angiotensin-converting enzyme genetic polymorphism: its impact on cardiac remodeling |
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