The number and location of EF hand motifs dictates the calcium dependence of polycystin‐2 function

ABSTRACT Polycystin 2 (PC2) is a calcium‐dependent calcium channel, and mutations to human PC2 (hPC2) are associated with polycystic kidney disease. The C‐terminal tail of hPC2 contains 2 EF hand motifs, but only the second binds calcium. Here, we investigate whether these EF hand motifs serve as a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The FASEB journal 2014-05, Vol.28 (5), p.2332-2346
Hauptverfasser:	Kuo, Ivana Y., Keeler, Camille, Corbin, Rachel, Ćelić, Andjelka, Petri, Edward T., Hodsdon, Michael E., Ehrlich, Barbara E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Animals Binding Sites Calcium - metabolism Calcium Channels - metabolism Cell Line Computational Biology EF Hand Motifs Humans intracellular release ion channels kidney Kidney - metabolism Lipid Bilayers - metabolism Magnetic Resonance Spectroscopy Molecular Sequence Data Phylogeny Plasmids - metabolism Protein Binding Research Communications Sea Urchins Sequence Homology, Amino Acid Signal Transduction signaling Swine TRP channels TRPP Cation Channels - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!