Reprogramming the Chemodiversity of Terpenoid Cyclization by Remolding the Active Site Contour of epi-Isozizaene Synthase

The class I terpenoid cyclase epi-isozizaene synthase (EIZS) utilizes the universal achiral isoprenoid substrate, farnesyl diphosphate, to generate epi-isozizaene as the predominant sesquiterpene cyclization product and at least five minor sesquiterpene products, making EIZS an ideal platform for th...

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Veröffentlicht in:	Biochemistry (Easton) 2014-02, Vol.53 (7), p.1155-1168
Hauptverfasser:	Li, Ruiqiong, Chou, Wayne K. W, Himmelberger, Julie A, Litwin, Kevin M, Harris, Golda G, Cane, David E, Christianson, David W
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - chemistry Bacterial Proteins - metabolism Catalytic Domain Crystallography, X-Ray Cyclization Kinetics Models, Molecular Molecular Structure Mutagenesis, Site-Directed Streptomyces coelicolor - enzymology Terpenes - chemistry Terpenes - metabolism
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