Highly Efficient Macromolecule-Sized Poration of Lipid Bilayers by a Synthetically Evolved Peptide

Peptides that self-assemble, at low concentration, into bilayer-spanning pores which allow the passage of macromolecules would be beneficial in multiple areas of biotechnology. However, there are few, if any, natural or designed peptides that have this property. Here we show that the 26-residue pept...

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Veröffentlicht in:	Journal of the American Chemical Society 2014-03, Vol.136 (12), p.4724-4731
Hauptverfasser:	Wiedman, Gregory, Fuselier, Taylor, He, Jing, Searson, Peter C, Hristova, Kalina, Wimley, William C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Conductance Evolution High strength steels Leakage Lipid Bilayers - metabolism Macromolecules Melitten - chemical synthesis Melitten - chemistry Melitten - metabolism Molecular Sequence Data Peptides Porosity Protein Structure, Secondary Vesicles
Online-Zugang:	Volltext
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