A potential role for B cells in suppressed immune responses in cord blood transplant recipients
We evaluated immune reconstitution in 58 adults who received hematopoietic SCTs from allogeneic siblings (allosib), matched unrelated donors (MUD) or cord blood (CB) at 90-day intervals for 1 year post transplant. CB recipients had a higher incidence of infections in the first 100 days compared with...
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| Veröffentlicht in: | Bone marrow transplantation (Basingstoke) 2013-01, Vol.48 (1), p.85-93 |
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| container_title | Bone marrow transplantation (Basingstoke) |
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| creator | Beaudette-Zlatanova, B C Le, P T Knight, K L Zhang, S Zakrzewski, S Parthasarathy, M Stiff, P J |
| description | We evaluated immune reconstitution in 58 adults who received hematopoietic SCTs from allogeneic siblings (allosib), matched unrelated donors (MUD) or cord blood (CB) at 90-day intervals for 1 year post transplant. CB recipients had a higher incidence of infections in the first 100 days compared with allosib and MUD recipients. The number of circulating T cells was lower in CB recipients compared with MUD recipients at 90 days and compared with allosib recipients at 180 days. Spectratype analysis of the TCR Vβ complementarity determining region 3 (CDR3) of patient lymphocytes revealed that the TCR repertoire remained poorly diversified even at 360 days in nearly all patients. In contrast, the number of circulating B cells was significantly elevated in CB recipients compared with allosib recipients throughout the first year post transplant and compared with MUD recipients at 9–12 months. Spectratype analysis of the B-cell receptor V
H
CDR3 showed that the B-cell repertoire was diversified in most patients by 90 days. CD5
pos
B cells from assayed CB recipients expressed intracellular IL-10 early post transplant. Our data suggest that B cells, in addition to T cells, may have a role in impaired immune responses in CB transplant patients. |
| doi_str_mv | 10.1038/bmt.2012.104 |
| format | Article |
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H
CDR3 showed that the B-cell repertoire was diversified in most patients by 90 days. CD5
pos
B cells from assayed CB recipients expressed intracellular IL-10 early post transplant. Our data suggest that B cells, in addition to T cells, may have a role in impaired immune responses in CB transplant patients.</description><identifier>ISSN: 0268-3369</identifier><identifier>EISSN: 1476-5365</identifier><identifier>DOI: 10.1038/bmt.2012.104</identifier><identifier>PMID: 22732699</identifier><identifier>CODEN: BMTRE9</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/250/1619/40 ; 631/250/1904 ; 631/532/1542 ; Adult ; Aged ; Analysis ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; B cells ; B-cell receptor ; B-Lymphocytes - immunology ; B-Lymphocytes - metabolism ; Biological and medical sciences ; Bone marrow ; Bone marrow transplantation ; Bone marrow, stem cells transplantation. Graft versus host reaction ; CD5 Antigens - blood ; CD5 Antigens - genetics ; CD5 Antigens - metabolism ; Cell Biology ; Complementarity Determining Regions - blood ; Complementarity Determining Regions - chemistry ; Complementarity Determining Regions - genetics ; Complementarity Determining Regions - metabolism ; complementarity-determining region 3 ; Cord blood ; Cord Blood Stem Cell Transplantation - adverse effects ; Data processing ; Donors ; Female ; Fetal blood ; Graft vs Host Disease - blood ; Graft vs Host Disease - epidemiology ; Graft vs Host Disease - immunology ; Graft vs Host Disease - metabolism ; Health aspects ; Hematology ; Hematopoietic Stem Cell Transplantation - adverse effects ; Hemopoiesis ; Humans ; Illinois - epidemiology ; Immune reconstitution ; Immune response ; Immunocompromised Host ; Incidence ; Infection ; Interleukin 10 ; Interleukin-10 - metabolism ; Internal Medicine ; Lymphocytes B ; Lymphocytes T ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Opportunistic Infections - blood ; Opportunistic Infections - epidemiology ; Opportunistic Infections - immunology ; Opportunistic Infections - metabolism ; Organ donors ; original-article ; Physiological aspects ; Public Health ; Receptors, Antigen, B-Cell - blood ; Receptors, Antigen, B-Cell - chemistry ; Receptors, Antigen, B-Cell - genetics ; Receptors, Antigen, B-Cell - metabolism ; Receptors, Antigen, T-Cell - blood ; Receptors, Antigen, T-Cell - chemistry ; Receptors, Antigen, T-Cell - genetics ; Receptors, Antigen, T-Cell - metabolism ; Siblings ; Stem cell transplantation ; Stem Cells ; T-cell receptor ; T-Lymphocytes - immunology ; T-Lymphocytes - metabolism ; Transfusions. Complications. Transfusion reactions. 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CB recipients had a higher incidence of infections in the first 100 days compared with allosib and MUD recipients. The number of circulating T cells was lower in CB recipients compared with MUD recipients at 90 days and compared with allosib recipients at 180 days. Spectratype analysis of the TCR Vβ complementarity determining region 3 (CDR3) of patient lymphocytes revealed that the TCR repertoire remained poorly diversified even at 360 days in nearly all patients. In contrast, the number of circulating B cells was significantly elevated in CB recipients compared with allosib recipients throughout the first year post transplant and compared with MUD recipients at 9–12 months. Spectratype analysis of the B-cell receptor V
H
CDR3 showed that the B-cell repertoire was diversified in most patients by 90 days. CD5
pos
B cells from assayed CB recipients expressed intracellular IL-10 early post transplant. Our data suggest that B cells, in addition to T cells, may have a role in impaired immune responses in CB transplant patients.</description><subject>631/250/1619/40</subject><subject>631/250/1904</subject><subject>631/532/1542</subject><subject>Adult</subject><subject>Aged</subject><subject>Analysis</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>B cells</subject><subject>B-cell receptor</subject><subject>B-Lymphocytes - immunology</subject><subject>B-Lymphocytes - metabolism</subject><subject>Biological and medical sciences</subject><subject>Bone marrow</subject><subject>Bone marrow transplantation</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>CD5 Antigens - blood</subject><subject>CD5 Antigens - genetics</subject><subject>CD5 Antigens - metabolism</subject><subject>Cell Biology</subject><subject>Complementarity Determining Regions - blood</subject><subject>Complementarity Determining Regions - chemistry</subject><subject>Complementarity Determining Regions - genetics</subject><subject>Complementarity Determining Regions - metabolism</subject><subject>complementarity-determining region 3</subject><subject>Cord blood</subject><subject>Cord Blood Stem Cell Transplantation - adverse effects</subject><subject>Data processing</subject><subject>Donors</subject><subject>Female</subject><subject>Fetal blood</subject><subject>Graft vs Host Disease - blood</subject><subject>Graft vs Host Disease - epidemiology</subject><subject>Graft vs Host Disease - immunology</subject><subject>Graft vs Host Disease - metabolism</subject><subject>Health aspects</subject><subject>Hematology</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Hemopoiesis</subject><subject>Humans</subject><subject>Illinois - epidemiology</subject><subject>Immune reconstitution</subject><subject>Immune response</subject><subject>Immunocompromised Host</subject><subject>Incidence</subject><subject>Infection</subject><subject>Interleukin 10</subject><subject>Interleukin-10 - metabolism</subject><subject>Internal Medicine</subject><subject>Lymphocytes B</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Opportunistic Infections - blood</subject><subject>Opportunistic Infections - epidemiology</subject><subject>Opportunistic Infections - immunology</subject><subject>Opportunistic Infections - metabolism</subject><subject>Organ donors</subject><subject>original-article</subject><subject>Physiological aspects</subject><subject>Public Health</subject><subject>Receptors, Antigen, B-Cell - blood</subject><subject>Receptors, Antigen, B-Cell - chemistry</subject><subject>Receptors, Antigen, B-Cell - genetics</subject><subject>Receptors, Antigen, B-Cell - metabolism</subject><subject>Receptors, Antigen, T-Cell - blood</subject><subject>Receptors, Antigen, T-Cell - chemistry</subject><subject>Receptors, Antigen, T-Cell - genetics</subject><subject>Receptors, Antigen, T-Cell - metabolism</subject><subject>Siblings</subject><subject>Stem cell transplantation</subject><subject>Stem Cells</subject><subject>T-cell receptor</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - metabolism</subject><subject>Transfusions. Complications. Transfusion reactions. 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Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>B cells</topic><topic>B-cell receptor</topic><topic>B-Lymphocytes - immunology</topic><topic>B-Lymphocytes - metabolism</topic><topic>Biological and medical sciences</topic><topic>Bone marrow</topic><topic>Bone marrow transplantation</topic><topic>Bone marrow, stem cells transplantation. Graft versus host reaction</topic><topic>CD5 Antigens - blood</topic><topic>CD5 Antigens - genetics</topic><topic>CD5 Antigens - metabolism</topic><topic>Cell Biology</topic><topic>Complementarity Determining Regions - blood</topic><topic>Complementarity Determining Regions - chemistry</topic><topic>Complementarity Determining Regions - genetics</topic><topic>Complementarity Determining Regions - metabolism</topic><topic>complementarity-determining region 3</topic><topic>Cord blood</topic><topic>Cord Blood Stem Cell Transplantation - adverse effects</topic><topic>Data processing</topic><topic>Donors</topic><topic>Female</topic><topic>Fetal blood</topic><topic>Graft vs Host Disease - blood</topic><topic>Graft vs Host Disease - epidemiology</topic><topic>Graft vs Host Disease - immunology</topic><topic>Graft vs Host Disease - metabolism</topic><topic>Health aspects</topic><topic>Hematology</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Hemopoiesis</topic><topic>Humans</topic><topic>Illinois - epidemiology</topic><topic>Immune reconstitution</topic><topic>Immune response</topic><topic>Immunocompromised Host</topic><topic>Incidence</topic><topic>Infection</topic><topic>Interleukin 10</topic><topic>Interleukin-10 - metabolism</topic><topic>Internal Medicine</topic><topic>Lymphocytes B</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Opportunistic Infections - blood</topic><topic>Opportunistic Infections - epidemiology</topic><topic>Opportunistic Infections - immunology</topic><topic>Opportunistic Infections - metabolism</topic><topic>Organ donors</topic><topic>original-article</topic><topic>Physiological aspects</topic><topic>Public Health</topic><topic>Receptors, Antigen, B-Cell - blood</topic><topic>Receptors, Antigen, B-Cell - chemistry</topic><topic>Receptors, Antigen, B-Cell - genetics</topic><topic>Receptors, Antigen, B-Cell - metabolism</topic><topic>Receptors, Antigen, T-Cell - blood</topic><topic>Receptors, Antigen, T-Cell - chemistry</topic><topic>Receptors, Antigen, T-Cell - genetics</topic><topic>Receptors, Antigen, T-Cell - metabolism</topic><topic>Siblings</topic><topic>Stem cell transplantation</topic><topic>Stem Cells</topic><topic>T-cell receptor</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - metabolism</topic><topic>Transfusions. Complications. Transfusion reactions. 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CB recipients had a higher incidence of infections in the first 100 days compared with allosib and MUD recipients. The number of circulating T cells was lower in CB recipients compared with MUD recipients at 90 days and compared with allosib recipients at 180 days. Spectratype analysis of the TCR Vβ complementarity determining region 3 (CDR3) of patient lymphocytes revealed that the TCR repertoire remained poorly diversified even at 360 days in nearly all patients. In contrast, the number of circulating B cells was significantly elevated in CB recipients compared with allosib recipients throughout the first year post transplant and compared with MUD recipients at 9–12 months. Spectratype analysis of the B-cell receptor V
H
CDR3 showed that the B-cell repertoire was diversified in most patients by 90 days. CD5
pos
B cells from assayed CB recipients expressed intracellular IL-10 early post transplant. Our data suggest that B cells, in addition to T cells, may have a role in impaired immune responses in CB transplant patients.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>22732699</pmid><doi>10.1038/bmt.2012.104</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0268-3369 |
| ispartof | Bone marrow transplantation (Basingstoke), 2013-01, Vol.48 (1), p.85-93 |
| issn | 0268-3369 1476-5365 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3985415 |
| source | MEDLINE; Nature Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerLink Journals - AutoHoldings |
| subjects | 631/250/1619/40 631/250/1904 631/532/1542 Adult Aged Analysis Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy B cells B-cell receptor B-Lymphocytes - immunology B-Lymphocytes - metabolism Biological and medical sciences Bone marrow Bone marrow transplantation Bone marrow, stem cells transplantation. Graft versus host reaction CD5 Antigens - blood CD5 Antigens - genetics CD5 Antigens - metabolism Cell Biology Complementarity Determining Regions - blood Complementarity Determining Regions - chemistry Complementarity Determining Regions - genetics Complementarity Determining Regions - metabolism complementarity-determining region 3 Cord blood Cord Blood Stem Cell Transplantation - adverse effects Data processing Donors Female Fetal blood Graft vs Host Disease - blood Graft vs Host Disease - epidemiology Graft vs Host Disease - immunology Graft vs Host Disease - metabolism Health aspects Hematology Hematopoietic Stem Cell Transplantation - adverse effects Hemopoiesis Humans Illinois - epidemiology Immune reconstitution Immune response Immunocompromised Host Incidence Infection Interleukin 10 Interleukin-10 - metabolism Internal Medicine Lymphocytes B Lymphocytes T Male Medical sciences Medicine Medicine & Public Health Middle Aged Opportunistic Infections - blood Opportunistic Infections - epidemiology Opportunistic Infections - immunology Opportunistic Infections - metabolism Organ donors original-article Physiological aspects Public Health Receptors, Antigen, B-Cell - blood Receptors, Antigen, B-Cell - chemistry Receptors, Antigen, B-Cell - genetics Receptors, Antigen, B-Cell - metabolism Receptors, Antigen, T-Cell - blood Receptors, Antigen, T-Cell - chemistry Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - metabolism Siblings Stem cell transplantation Stem Cells T-cell receptor T-Lymphocytes - immunology T-Lymphocytes - metabolism Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation, Homologous |
| title | A potential role for B cells in suppressed immune responses in cord blood transplant recipients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T01%3A35%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20potential%20role%20for%20B%20cells%20in%20suppressed%20immune%20responses%20in%20cord%20blood%20transplant%20recipients&rft.jtitle=Bone%20marrow%20transplantation%20(Basingstoke)&rft.au=Beaudette-Zlatanova,%20B%20C&rft.date=2013-01-01&rft.volume=48&rft.issue=1&rft.spage=85&rft.epage=93&rft.pages=85-93&rft.issn=0268-3369&rft.eissn=1476-5365&rft.coden=BMTRE9&rft_id=info:doi/10.1038/bmt.2012.104&rft_dat=%3Cgale_pubme%3EA315222240%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1267456368&rft_id=info:pmid/22732699&rft_galeid=A315222240&rfr_iscdi=true |