BACs-on-Beads Technology : A Reliable Test for Rapid Detection of Aneuploidies and Microdeletions in Prenatal Diagnosis
The risk of fetal aneuploidies is usually estimated based on high resolution ultrasound combined with biochemical determination of criterion in maternal blood, with invasive procedures offered to the population at risk. The purpose of this study was to investigate the effectiveness of a new rapid an...
Gespeichert in:
| Veröffentlicht in: | BioMed research international 2014-01, Vol.2014 (2014), p.1-7 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 7 |
|---|---|
| container_issue | 2014 |
| container_start_page | 1 |
| container_title | BioMed research international |
| container_volume | 2014 |
| creator | García-Herrero, Sandra Campos-Galindo, Inmaculada Martínez-Conejero, José Antonio Serra, Vicente Olmo, Inés Lara, Coral Simón, Carlos Rubio, Carmen |
| description | The risk of fetal aneuploidies is usually estimated based on high resolution ultrasound combined with biochemical determination of criterion in maternal blood, with invasive procedures offered to the population at risk. The purpose of this study was to investigate the effectiveness of a new rapid aneuploidy screening test on amniotic fluid (AF) or chorionic villus (CV) samples based on BACs-on-Beads (BoBs) technology and to compare the results with classical karyotyping by Giemsa banding (G-banding) of cultured cells in metaphase as the gold standard technique. The prenatal-BoBs kit was used to study aneuploidies involving chromosomes 13, 18, 21, X, and Y as well as nine microdeletion syndromes in 321 AF and 43 CV samples. G-banding of metaphase cultured cells was performed concomitantly for all prenatal samples. A microarray-based comparative genomic hybridization (aCGH) was also carried out in a subset of samples. Prenatal-BoBs results were widely confirmed by classical karyotyping. Only six karyotype findings were not identified by Prenatal-BoBs, all of them due to the known limitations of the technique. In summary, the BACs-on-Beads technology was an accurate, robust, and efficient method for the rapid diagnosis of common aneuploidies and microdeletion syndromes in prenatal samples. |
| doi_str_mv | 10.1155/2014/590298 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3985206</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A427023675</galeid><sourcerecordid>A427023675</sourcerecordid><originalsourceid>FETCH-LOGICAL-c527t-ba688044eafbb01deb6417ba1253ebac5b7d75fce4ae1e0349d83c3d9b6e78f73</originalsourceid><addsrcrecordid>eNqN0strFTEUB-BBFFtqV66VgBuxjM1zJuNCmN76gopS6jokkzP3puQm18mMpf99M0y9PjaaTULy8SM5OUXxlODXhAhxSjHhp6LBtJEPikPKCC8rwsnD_Zqxg-I4pWuchyQVbqrHxQHldSOkrA-Lm7N2lcoYyjPQNqEr6DYh-ri-RW9Qiy7BO2085P00oj4O6FLvnEXnMEI3uhhQ7FEbYNr56KyDhHSw6LPrhmjBwywScgF9HSDoUXt07vQ6xOTSk-JRr32C4_v5qPj2_t3V6mN58eXDp1V7UXaC1mNpdCUl5hx0bwwmFkzFSW00oYKB0Z0wta1F3wHXQAAz3ljJOmYbU0Et-5odFW-X3N1ktmA7COOgvdoNbquHWxW1U3-eBLdR6_hDsUYKiqsc8PI-YIjfp1wGtXWpA-91gDglRQTlnDIq_ovm7yCUz_TFX_Q6TkPIlciqqvJ3NkT-UmvtQbnQx3zFbg5VLac1pqyqRVYni8pVT2mAfv86gtXcJGpuErU0SdbPfy_I3v5siQxeLWDjgtU37h9pzxYMmUCv95hLRvML7gDnKsx_</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1566029918</pqid></control><display><type>article</type><title>BACs-on-Beads Technology : A Reliable Test for Rapid Detection of Aneuploidies and Microdeletions in Prenatal Diagnosis</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>Wiley Online Library (Open Access Collection)</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>García-Herrero, Sandra ; Campos-Galindo, Inmaculada ; Martínez-Conejero, José Antonio ; Serra, Vicente ; Olmo, Inés ; Lara, Coral ; Simón, Carlos ; Rubio, Carmen</creator><contributor>Virant-Klun, Irma</contributor><creatorcontrib>García-Herrero, Sandra ; Campos-Galindo, Inmaculada ; Martínez-Conejero, José Antonio ; Serra, Vicente ; Olmo, Inés ; Lara, Coral ; Simón, Carlos ; Rubio, Carmen ; Virant-Klun, Irma</creatorcontrib><description>The risk of fetal aneuploidies is usually estimated based on high resolution ultrasound combined with biochemical determination of criterion in maternal blood, with invasive procedures offered to the population at risk. The purpose of this study was to investigate the effectiveness of a new rapid aneuploidy screening test on amniotic fluid (AF) or chorionic villus (CV) samples based on BACs-on-Beads (BoBs) technology and to compare the results with classical karyotyping by Giemsa banding (G-banding) of cultured cells in metaphase as the gold standard technique. The prenatal-BoBs kit was used to study aneuploidies involving chromosomes 13, 18, 21, X, and Y as well as nine microdeletion syndromes in 321 AF and 43 CV samples. G-banding of metaphase cultured cells was performed concomitantly for all prenatal samples. A microarray-based comparative genomic hybridization (aCGH) was also carried out in a subset of samples. Prenatal-BoBs results were widely confirmed by classical karyotyping. Only six karyotype findings were not identified by Prenatal-BoBs, all of them due to the known limitations of the technique. In summary, the BACs-on-Beads technology was an accurate, robust, and efficient method for the rapid diagnosis of common aneuploidies and microdeletion syndromes in prenatal samples.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/590298</identifier><identifier>PMID: 24795887</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Amniotic Fluid - chemistry ; Aneuploidy ; Artificial chromosomes ; Automation ; Biomedical research ; Chorionic Villi Sampling ; Chromosome Aberrations ; Comparative Genomic Hybridization ; Defects ; Diagnosis ; Down syndrome ; Female ; Genetic counseling ; Genetic Testing - methods ; Genomes ; Humans ; Karyotyping ; Laboratories ; Obstetrics ; Pregnancy ; Prenatal diagnosis ; Prenatal Diagnosis - methods ; Technology application ; Ultrasonic imaging</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-7</ispartof><rights>Copyright © 2014 Sandra García-Herrero et al.</rights><rights>COPYRIGHT 2014 John Wiley & Sons, Inc.</rights><rights>Copyright © 2014 Sandra García-Herrero et al. Sandra García-Herrero et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Sandra García-Herrero et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-ba688044eafbb01deb6417ba1253ebac5b7d75fce4ae1e0349d83c3d9b6e78f73</citedby><cites>FETCH-LOGICAL-c527t-ba688044eafbb01deb6417ba1253ebac5b7d75fce4ae1e0349d83c3d9b6e78f73</cites><orcidid>0000-0003-3961-8628 ; 0000-0002-7582-3875 ; 0000-0002-7482-9052</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985206/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985206/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24795887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Virant-Klun, Irma</contributor><creatorcontrib>García-Herrero, Sandra</creatorcontrib><creatorcontrib>Campos-Galindo, Inmaculada</creatorcontrib><creatorcontrib>Martínez-Conejero, José Antonio</creatorcontrib><creatorcontrib>Serra, Vicente</creatorcontrib><creatorcontrib>Olmo, Inés</creatorcontrib><creatorcontrib>Lara, Coral</creatorcontrib><creatorcontrib>Simón, Carlos</creatorcontrib><creatorcontrib>Rubio, Carmen</creatorcontrib><title>BACs-on-Beads Technology : A Reliable Test for Rapid Detection of Aneuploidies and Microdeletions in Prenatal Diagnosis</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>The risk of fetal aneuploidies is usually estimated based on high resolution ultrasound combined with biochemical determination of criterion in maternal blood, with invasive procedures offered to the population at risk. The purpose of this study was to investigate the effectiveness of a new rapid aneuploidy screening test on amniotic fluid (AF) or chorionic villus (CV) samples based on BACs-on-Beads (BoBs) technology and to compare the results with classical karyotyping by Giemsa banding (G-banding) of cultured cells in metaphase as the gold standard technique. The prenatal-BoBs kit was used to study aneuploidies involving chromosomes 13, 18, 21, X, and Y as well as nine microdeletion syndromes in 321 AF and 43 CV samples. G-banding of metaphase cultured cells was performed concomitantly for all prenatal samples. A microarray-based comparative genomic hybridization (aCGH) was also carried out in a subset of samples. Prenatal-BoBs results were widely confirmed by classical karyotyping. Only six karyotype findings were not identified by Prenatal-BoBs, all of them due to the known limitations of the technique. In summary, the BACs-on-Beads technology was an accurate, robust, and efficient method for the rapid diagnosis of common aneuploidies and microdeletion syndromes in prenatal samples.</description><subject>Amniotic Fluid - chemistry</subject><subject>Aneuploidy</subject><subject>Artificial chromosomes</subject><subject>Automation</subject><subject>Biomedical research</subject><subject>Chorionic Villi Sampling</subject><subject>Chromosome Aberrations</subject><subject>Comparative Genomic Hybridization</subject><subject>Defects</subject><subject>Diagnosis</subject><subject>Down syndrome</subject><subject>Female</subject><subject>Genetic counseling</subject><subject>Genetic Testing - methods</subject><subject>Genomes</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Laboratories</subject><subject>Obstetrics</subject><subject>Pregnancy</subject><subject>Prenatal diagnosis</subject><subject>Prenatal Diagnosis - methods</subject><subject>Technology application</subject><subject>Ultrasonic imaging</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqN0strFTEUB-BBFFtqV66VgBuxjM1zJuNCmN76gopS6jokkzP3puQm18mMpf99M0y9PjaaTULy8SM5OUXxlODXhAhxSjHhp6LBtJEPikPKCC8rwsnD_Zqxg-I4pWuchyQVbqrHxQHldSOkrA-Lm7N2lcoYyjPQNqEr6DYh-ri-RW9Qiy7BO2085P00oj4O6FLvnEXnMEI3uhhQ7FEbYNr56KyDhHSw6LPrhmjBwywScgF9HSDoUXt07vQ6xOTSk-JRr32C4_v5qPj2_t3V6mN58eXDp1V7UXaC1mNpdCUl5hx0bwwmFkzFSW00oYKB0Z0wta1F3wHXQAAz3ljJOmYbU0Et-5odFW-X3N1ktmA7COOgvdoNbquHWxW1U3-eBLdR6_hDsUYKiqsc8PI-YIjfp1wGtXWpA-91gDglRQTlnDIq_ovm7yCUz_TFX_Q6TkPIlciqqvJ3NkT-UmvtQbnQx3zFbg5VLac1pqyqRVYni8pVT2mAfv86gtXcJGpuErU0SdbPfy_I3v5siQxeLWDjgtU37h9pzxYMmUCv95hLRvML7gDnKsx_</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>García-Herrero, Sandra</creator><creator>Campos-Galindo, Inmaculada</creator><creator>Martínez-Conejero, José Antonio</creator><creator>Serra, Vicente</creator><creator>Olmo, Inés</creator><creator>Lara, Coral</creator><creator>Simón, Carlos</creator><creator>Rubio, Carmen</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3961-8628</orcidid><orcidid>https://orcid.org/0000-0002-7582-3875</orcidid><orcidid>https://orcid.org/0000-0002-7482-9052</orcidid></search><sort><creationdate>20140101</creationdate><title>BACs-on-Beads Technology : A Reliable Test for Rapid Detection of Aneuploidies and Microdeletions in Prenatal Diagnosis</title><author>García-Herrero, Sandra ; Campos-Galindo, Inmaculada ; Martínez-Conejero, José Antonio ; Serra, Vicente ; Olmo, Inés ; Lara, Coral ; Simón, Carlos ; Rubio, Carmen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-ba688044eafbb01deb6417ba1253ebac5b7d75fce4ae1e0349d83c3d9b6e78f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Amniotic Fluid - chemistry</topic><topic>Aneuploidy</topic><topic>Artificial chromosomes</topic><topic>Automation</topic><topic>Biomedical research</topic><topic>Chorionic Villi Sampling</topic><topic>Chromosome Aberrations</topic><topic>Comparative Genomic Hybridization</topic><topic>Defects</topic><topic>Diagnosis</topic><topic>Down syndrome</topic><topic>Female</topic><topic>Genetic counseling</topic><topic>Genetic Testing - methods</topic><topic>Genomes</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>Laboratories</topic><topic>Obstetrics</topic><topic>Pregnancy</topic><topic>Prenatal diagnosis</topic><topic>Prenatal Diagnosis - methods</topic><topic>Technology application</topic><topic>Ultrasonic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>García-Herrero, Sandra</creatorcontrib><creatorcontrib>Campos-Galindo, Inmaculada</creatorcontrib><creatorcontrib>Martínez-Conejero, José Antonio</creatorcontrib><creatorcontrib>Serra, Vicente</creatorcontrib><creatorcontrib>Olmo, Inés</creatorcontrib><creatorcontrib>Lara, Coral</creatorcontrib><creatorcontrib>Simón, Carlos</creatorcontrib><creatorcontrib>Rubio, Carmen</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>García-Herrero, Sandra</au><au>Campos-Galindo, Inmaculada</au><au>Martínez-Conejero, José Antonio</au><au>Serra, Vicente</au><au>Olmo, Inés</au><au>Lara, Coral</au><au>Simón, Carlos</au><au>Rubio, Carmen</au><au>Virant-Klun, Irma</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BACs-on-Beads Technology : A Reliable Test for Rapid Detection of Aneuploidies and Microdeletions in Prenatal Diagnosis</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>2014</volume><issue>2014</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>The risk of fetal aneuploidies is usually estimated based on high resolution ultrasound combined with biochemical determination of criterion in maternal blood, with invasive procedures offered to the population at risk. The purpose of this study was to investigate the effectiveness of a new rapid aneuploidy screening test on amniotic fluid (AF) or chorionic villus (CV) samples based on BACs-on-Beads (BoBs) technology and to compare the results with classical karyotyping by Giemsa banding (G-banding) of cultured cells in metaphase as the gold standard technique. The prenatal-BoBs kit was used to study aneuploidies involving chromosomes 13, 18, 21, X, and Y as well as nine microdeletion syndromes in 321 AF and 43 CV samples. G-banding of metaphase cultured cells was performed concomitantly for all prenatal samples. A microarray-based comparative genomic hybridization (aCGH) was also carried out in a subset of samples. Prenatal-BoBs results were widely confirmed by classical karyotyping. Only six karyotype findings were not identified by Prenatal-BoBs, all of them due to the known limitations of the technique. In summary, the BACs-on-Beads technology was an accurate, robust, and efficient method for the rapid diagnosis of common aneuploidies and microdeletion syndromes in prenatal samples.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>24795887</pmid><doi>10.1155/2014/590298</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-3961-8628</orcidid><orcidid>https://orcid.org/0000-0002-7582-3875</orcidid><orcidid>https://orcid.org/0000-0002-7482-9052</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2314-6133 |
| ispartof | BioMed research international, 2014-01, Vol.2014 (2014), p.1-7 |
| issn | 2314-6133 2314-6141 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3985206 |
| source | MEDLINE; PubMed Central Open Access; Wiley Online Library (Open Access Collection); PubMed Central; Alma/SFX Local Collection |
| subjects | Amniotic Fluid - chemistry Aneuploidy Artificial chromosomes Automation Biomedical research Chorionic Villi Sampling Chromosome Aberrations Comparative Genomic Hybridization Defects Diagnosis Down syndrome Female Genetic counseling Genetic Testing - methods Genomes Humans Karyotyping Laboratories Obstetrics Pregnancy Prenatal diagnosis Prenatal Diagnosis - methods Technology application Ultrasonic imaging |
| title | BACs-on-Beads Technology : A Reliable Test for Rapid Detection of Aneuploidies and Microdeletions in Prenatal Diagnosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T17%3A12%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=BACs-on-Beads%20Technology%20:%20A%20Reliable%20Test%20for%20Rapid%20Detection%20of%20Aneuploidies%20and%20Microdeletions%20in%20Prenatal%20Diagnosis&rft.jtitle=BioMed%20research%20international&rft.au=Garc%C3%ADa-Herrero,%20Sandra&rft.date=2014-01-01&rft.volume=2014&rft.issue=2014&rft.spage=1&rft.epage=7&rft.pages=1-7&rft.issn=2314-6133&rft.eissn=2314-6141&rft_id=info:doi/10.1155/2014/590298&rft_dat=%3Cgale_pubme%3EA427023675%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1566029918&rft_id=info:pmid/24795887&rft_galeid=A427023675&rfr_iscdi=true |