Reduced Binding Potential of GABA-A/Benzodiazepine Receptors in Individuals at Ultra-high Risk for Psychosis: An [18F]-Fluoroflumazenil Positron Emission Tomography Study

Altered transmission of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter, may contribute to the development of schizophrenia. The purpose of the present study was to investigate the presence of GABA-A/benzodiazepine (BZ) receptor binding abnormalities in individuals at ultra-high...

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Veröffentlicht in:	Schizophrenia bulletin 2014-05, Vol.40 (3), p.548-557
Hauptverfasser:	JEE IN KANG, PARK, Hae-Jeong, SE JOO KIM, KYUNG RAN KIM, SU YOUNG LEE, EUN LEE, SUK KYOON AN, JUN SOO KWON, JONG DOO LEE
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult and adolescent clinical studies Biological and medical sciences Brain - diagnostic imaging Brain - metabolism Case-Control Studies Caudate Nucleus - diagnostic imaging Caudate Nucleus - metabolism Female Flumazenil - analogs & derivatives Flumazenil - metabolism gamma-Aminobutyric Acid - metabolism Hippocampus - diagnostic imaging Hippocampus - metabolism Humans Male Medical sciences Nucleus Accumbens - diagnostic imaging Nucleus Accumbens - metabolism Parahippocampal Gyrus - diagnostic imaging Parahippocampal Gyrus - metabolism Positron-Emission Tomography Prodromal Symptoms Protein Binding Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Putamen - diagnostic imaging Putamen - metabolism Receptors, GABA-A - metabolism Regular Risk Schizophrenia Schizophrenia - diagnostic imaging Schizophrenia - metabolism Young Adult
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