Reduced Binding Potential of GABA-A/Benzodiazepine Receptors in Individuals at Ultra-high Risk for Psychosis: An [18F]-Fluoroflumazenil Positron Emission Tomography Study
Altered transmission of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter, may contribute to the development of schizophrenia. The purpose of the present study was to investigate the presence of GABA-A/benzodiazepine (BZ) receptor binding abnormalities in individuals at ultra-high...
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| Veröffentlicht in: | Schizophrenia bulletin 2014-05, Vol.40 (3), p.548-557 |
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| creator | JEE IN KANG PARK, Hae-Jeong SE JOO KIM KYUNG RAN KIM SU YOUNG LEE EUN LEE SUK KYOON AN JUN SOO KWON JONG DOO LEE |
| description | Altered transmission of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter, may contribute to the development of schizophrenia. The purpose of the present study was to investigate the presence of GABA-A/benzodiazepine (BZ) receptor binding abnormalities in individuals at ultra-high risk (UHR) for psychosis in comparison with normal controls using [(18)F]-fluoroflumazenil (FFMZ) positron emission tomography (PET). In particular, we set regions of interest in the striatum (caudate, putamen, and nucleus accumbens) and medial temporal area (hippocampus and parahippocampal gyrus).
Eleven BZ-naive people at UHR and 15 normal controls underwent PET scanning using [(18)F]-FFMZ to measure GABA-A/BZ receptor binding potential. The regional group differences between UHR individuals and normal controls were analyzed using Statistical Parametric Mapping 8 software. Participants were evaluated using the structured interview for prodromal syndromes and neurocognitive function tasks.
People at UHR demonstrated significantly reduced binding potential of GABA-A/BZ receptors in the right caudate.
Altered GABAergic transmission and/or the imbalance of inhibitory and excitatory systems in the striatum may be present at the putative prodromal stage and play a pivotal role in the pathophysiology of psychosis. |
| doi_str_mv | 10.1093/schbul/sbt052 |
| format | Article |
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Eleven BZ-naive people at UHR and 15 normal controls underwent PET scanning using [(18)F]-FFMZ to measure GABA-A/BZ receptor binding potential. The regional group differences between UHR individuals and normal controls were analyzed using Statistical Parametric Mapping 8 software. Participants were evaluated using the structured interview for prodromal syndromes and neurocognitive function tasks.
People at UHR demonstrated significantly reduced binding potential of GABA-A/BZ receptors in the right caudate.
Altered GABAergic transmission and/or the imbalance of inhibitory and excitatory systems in the striatum may be present at the putative prodromal stage and play a pivotal role in the pathophysiology of psychosis.</description><identifier>ISSN: 0586-7614</identifier><identifier>EISSN: 1745-1701</identifier><identifier>DOI: 10.1093/schbul/sbt052</identifier><identifier>PMID: 23588475</identifier><identifier>CODEN: SCZBB3</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adolescent ; Adult and adolescent clinical studies ; Biological and medical sciences ; Brain - diagnostic imaging ; Brain - metabolism ; Case-Control Studies ; Caudate Nucleus - diagnostic imaging ; Caudate Nucleus - metabolism ; Female ; Flumazenil - analogs & derivatives ; Flumazenil - metabolism ; gamma-Aminobutyric Acid - metabolism ; Hippocampus - diagnostic imaging ; Hippocampus - metabolism ; Humans ; Male ; Medical sciences ; Nucleus Accumbens - diagnostic imaging ; Nucleus Accumbens - metabolism ; Parahippocampal Gyrus - diagnostic imaging ; Parahippocampal Gyrus - metabolism ; Positron-Emission Tomography ; Prodromal Symptoms ; Protein Binding ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Putamen - diagnostic imaging ; Putamen - metabolism ; Receptors, GABA-A - metabolism ; Regular ; Risk ; Schizophrenia ; Schizophrenia - diagnostic imaging ; Schizophrenia - metabolism ; Young Adult</subject><ispartof>Schizophrenia bulletin, 2014-05, Vol.40 (3), p.548-557</ispartof><rights>2015 INIST-CNRS</rights><rights>The Author 2013. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-c3cd94d4f0659ce2490f3bd2408e92a3c358636f259e9d7c3e94fa7d55fe01293</citedby><cites>FETCH-LOGICAL-c417t-c3cd94d4f0659ce2490f3bd2408e92a3c358636f259e9d7c3e94fa7d55fe01293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984508/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984508/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28506230$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23588475$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>JEE IN KANG</creatorcontrib><creatorcontrib>PARK, Hae-Jeong</creatorcontrib><creatorcontrib>SE JOO KIM</creatorcontrib><creatorcontrib>KYUNG RAN KIM</creatorcontrib><creatorcontrib>SU YOUNG LEE</creatorcontrib><creatorcontrib>EUN LEE</creatorcontrib><creatorcontrib>SUK KYOON AN</creatorcontrib><creatorcontrib>JUN SOO KWON</creatorcontrib><creatorcontrib>JONG DOO LEE</creatorcontrib><title>Reduced Binding Potential of GABA-A/Benzodiazepine Receptors in Individuals at Ultra-high Risk for Psychosis: An [18F]-Fluoroflumazenil Positron Emission Tomography Study</title><title>Schizophrenia bulletin</title><addtitle>Schizophr Bull</addtitle><description>Altered transmission of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter, may contribute to the development of schizophrenia. The purpose of the present study was to investigate the presence of GABA-A/benzodiazepine (BZ) receptor binding abnormalities in individuals at ultra-high risk (UHR) for psychosis in comparison with normal controls using [(18)F]-fluoroflumazenil (FFMZ) positron emission tomography (PET). In particular, we set regions of interest in the striatum (caudate, putamen, and nucleus accumbens) and medial temporal area (hippocampus and parahippocampal gyrus).
Eleven BZ-naive people at UHR and 15 normal controls underwent PET scanning using [(18)F]-FFMZ to measure GABA-A/BZ receptor binding potential. The regional group differences between UHR individuals and normal controls were analyzed using Statistical Parametric Mapping 8 software. Participants were evaluated using the structured interview for prodromal syndromes and neurocognitive function tasks.
People at UHR demonstrated significantly reduced binding potential of GABA-A/BZ receptors in the right caudate.
Altered GABAergic transmission and/or the imbalance of inhibitory and excitatory systems in the striatum may be present at the putative prodromal stage and play a pivotal role in the pathophysiology of psychosis.</description><subject>Adolescent</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - metabolism</subject><subject>Case-Control Studies</subject><subject>Caudate Nucleus - diagnostic imaging</subject><subject>Caudate Nucleus - metabolism</subject><subject>Female</subject><subject>Flumazenil - analogs & derivatives</subject><subject>Flumazenil - metabolism</subject><subject>gamma-Aminobutyric Acid - metabolism</subject><subject>Hippocampus - diagnostic imaging</subject><subject>Hippocampus - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nucleus Accumbens - diagnostic imaging</subject><subject>Nucleus Accumbens - metabolism</subject><subject>Parahippocampal Gyrus - diagnostic imaging</subject><subject>Parahippocampal Gyrus - metabolism</subject><subject>Positron-Emission Tomography</subject><subject>Prodromal Symptoms</subject><subject>Protein Binding</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Putamen - diagnostic imaging</subject><subject>Putamen - metabolism</subject><subject>Receptors, GABA-A - metabolism</subject><subject>Regular</subject><subject>Risk</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnostic imaging</subject><subject>Schizophrenia - metabolism</subject><subject>Young Adult</subject><issn>0586-7614</issn><issn>1745-1701</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtv1DAUhSMEokNhyRZ5g8QmjJ9JzAIpU3VKpUpUQ7tCKPL4MTE4dmonlaY_iV-J0QwFVrbkz-fcc09RvEbwPYKcLJPst7Nbpu0EGX5SLFBNWYlqiJ4WC8iaqqwrRE-KFyl9hxBRXuHnxQkmrGlozRbFz41Ws9QKrKxX1u_AdZi0n6xwIBhw0a7asl2utH8IyooHPVqvwUZLPU4hJmA9uMzf7q2ahUtATODWTVGUvd31YGPTD2BCBNdpL_uQbPoAWg--omb9rVy7OcRg3DxkVW9d9k12isGD88GmZPPlJgxhF8XY78GXaVb7l8Uzk130q-N5Wtyuz2_OPpVXny8uz9qrUlJUT6UkUnGqqIEV41JjyqEhW4UpbDTHgsicvSKVwYxrrmpJNKdG1IoxoyHCnJwWHw-647wdtJJ5HVG4box2EHHfBWG7_1-87btduO8IbyiDTRZ4dxSI4W7WaepyJKmdE16HOXWIoSqzGKGMlgdUxpBS1ObRBsHud7_dod_u0G_m3_w72yP9p9AMvD0CIknhTBRe2vSXaxisMIHkFyXAtCg</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>JEE IN KANG</creator><creator>PARK, Hae-Jeong</creator><creator>SE JOO KIM</creator><creator>KYUNG RAN KIM</creator><creator>SU YOUNG LEE</creator><creator>EUN LEE</creator><creator>SUK KYOON AN</creator><creator>JUN SOO KWON</creator><creator>JONG DOO LEE</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140501</creationdate><title>Reduced Binding Potential of GABA-A/Benzodiazepine Receptors in Individuals at Ultra-high Risk for Psychosis: An [18F]-Fluoroflumazenil Positron Emission Tomography Study</title><author>JEE IN KANG ; PARK, Hae-Jeong ; SE JOO KIM ; KYUNG RAN KIM ; SU YOUNG LEE ; EUN LEE ; SUK KYOON AN ; JUN SOO KWON ; JONG DOO LEE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-c3cd94d4f0659ce2490f3bd2408e92a3c358636f259e9d7c3e94fa7d55fe01293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - metabolism</topic><topic>Case-Control Studies</topic><topic>Caudate Nucleus - diagnostic imaging</topic><topic>Caudate Nucleus - metabolism</topic><topic>Female</topic><topic>Flumazenil - analogs & derivatives</topic><topic>Flumazenil - metabolism</topic><topic>gamma-Aminobutyric Acid - metabolism</topic><topic>Hippocampus - diagnostic imaging</topic><topic>Hippocampus - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nucleus Accumbens - diagnostic imaging</topic><topic>Nucleus Accumbens - metabolism</topic><topic>Parahippocampal Gyrus - diagnostic imaging</topic><topic>Parahippocampal Gyrus - metabolism</topic><topic>Positron-Emission Tomography</topic><topic>Prodromal Symptoms</topic><topic>Protein Binding</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Putamen - diagnostic imaging</topic><topic>Putamen - metabolism</topic><topic>Receptors, GABA-A - metabolism</topic><topic>Regular</topic><topic>Risk</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnostic imaging</topic><topic>Schizophrenia - metabolism</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JEE IN KANG</creatorcontrib><creatorcontrib>PARK, Hae-Jeong</creatorcontrib><creatorcontrib>SE JOO KIM</creatorcontrib><creatorcontrib>KYUNG RAN KIM</creatorcontrib><creatorcontrib>SU YOUNG LEE</creatorcontrib><creatorcontrib>EUN LEE</creatorcontrib><creatorcontrib>SUK KYOON AN</creatorcontrib><creatorcontrib>JUN SOO KWON</creatorcontrib><creatorcontrib>JONG DOO LEE</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Schizophrenia bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JEE IN KANG</au><au>PARK, Hae-Jeong</au><au>SE JOO KIM</au><au>KYUNG RAN KIM</au><au>SU YOUNG LEE</au><au>EUN LEE</au><au>SUK KYOON AN</au><au>JUN SOO KWON</au><au>JONG DOO LEE</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced Binding Potential of GABA-A/Benzodiazepine Receptors in Individuals at Ultra-high Risk for Psychosis: An [18F]-Fluoroflumazenil Positron Emission Tomography Study</atitle><jtitle>Schizophrenia bulletin</jtitle><addtitle>Schizophr Bull</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>40</volume><issue>3</issue><spage>548</spage><epage>557</epage><pages>548-557</pages><issn>0586-7614</issn><eissn>1745-1701</eissn><coden>SCZBB3</coden><abstract>Altered transmission of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter, may contribute to the development of schizophrenia. The purpose of the present study was to investigate the presence of GABA-A/benzodiazepine (BZ) receptor binding abnormalities in individuals at ultra-high risk (UHR) for psychosis in comparison with normal controls using [(18)F]-fluoroflumazenil (FFMZ) positron emission tomography (PET). In particular, we set regions of interest in the striatum (caudate, putamen, and nucleus accumbens) and medial temporal area (hippocampus and parahippocampal gyrus).
Eleven BZ-naive people at UHR and 15 normal controls underwent PET scanning using [(18)F]-FFMZ to measure GABA-A/BZ receptor binding potential. The regional group differences between UHR individuals and normal controls were analyzed using Statistical Parametric Mapping 8 software. Participants were evaluated using the structured interview for prodromal syndromes and neurocognitive function tasks.
People at UHR demonstrated significantly reduced binding potential of GABA-A/BZ receptors in the right caudate.
Altered GABAergic transmission and/or the imbalance of inhibitory and excitatory systems in the striatum may be present at the putative prodromal stage and play a pivotal role in the pathophysiology of psychosis.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>23588475</pmid><doi>10.1093/schbul/sbt052</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Schizophrenia bulletin, 2014-05, Vol.40 (3), p.548-557 |
| issn | 0586-7614 1745-1701 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3984508 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adolescent Adult and adolescent clinical studies Biological and medical sciences Brain - diagnostic imaging Brain - metabolism Case-Control Studies Caudate Nucleus - diagnostic imaging Caudate Nucleus - metabolism Female Flumazenil - analogs & derivatives Flumazenil - metabolism gamma-Aminobutyric Acid - metabolism Hippocampus - diagnostic imaging Hippocampus - metabolism Humans Male Medical sciences Nucleus Accumbens - diagnostic imaging Nucleus Accumbens - metabolism Parahippocampal Gyrus - diagnostic imaging Parahippocampal Gyrus - metabolism Positron-Emission Tomography Prodromal Symptoms Protein Binding Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Putamen - diagnostic imaging Putamen - metabolism Receptors, GABA-A - metabolism Regular Risk Schizophrenia Schizophrenia - diagnostic imaging Schizophrenia - metabolism Young Adult |
| title | Reduced Binding Potential of GABA-A/Benzodiazepine Receptors in Individuals at Ultra-high Risk for Psychosis: An [18F]-Fluoroflumazenil Positron Emission Tomography Study |
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