In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators

Hair follicle stem cells (HFSCs) regenerate hair in response to Wnt signalling. Here, we unfold genome-wide transcriptional and chromatin landscapes of β-catenin–TCF3/4–TLE circuitry, and genetically dissect their biological roles within the native HFSC niche. We show that during HFSC quiescence, TC...

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Veröffentlicht in:	Nature cell biology 2014-02, Vol.16 (2), p.179-190
Hauptverfasser:	Lien, Wen-Hui, Polak, Lisa, Lin, Mingyan, Lay, Kenneth, Zheng, Deyou, Fuchs, Elaine
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/334/1874/345 631/136/532/1360 Animals Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism Basic Helix-Loop-Helix Transcription Factors - metabolism beta Catenin - physiology Cancer Research Cell Biology Cell Differentiation Cellular signal transduction Developmental Biology Genetic aspects Hair Hair Follicle - cytology Hair Follicle - metabolism Hair follicles Life Sciences Mice Mice, Knockout Physiological aspects Regeneration Signal Transduction Stem Cells Transcription Factor 4 Transcription, Genetic Wnt Proteins - metabolism
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