Acetylation-Mediated Proteasomal Degradation of Core Histones during DNA Repair and Spermatogenesis

Histone acetylation plays critical roles in chromatin remodeling, DNA repair, and epigenetic regulation of gene expression, but the underlying mechanisms are unclear. Proteasomes usually catalyze ATP- and polyubiquitin-dependent proteolysis. Here, we show that the proteasomes containing the activato...

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Veröffentlicht in:	Cell 2013-05, Vol.153 (5), p.1012-1024
Hauptverfasser:	Qian, Min-Xian, Pang, Ye, Liu, Cui Hua, Haratake, Kousuke, Du, Bo-Yu, Ji, Dan-Yang, Wang, Guang-Fei, Zhu, Qian-Qian, Song, Wei, Yu, Yadong, Zhang, Xiao-Xu, Huang, Hai-Tao, Miao, Shiying, Chen, Lian-Bin, Zhang, Zi-Hui, Liang, Ya-Nan, Liu, Shan, Cha, Hwangho, Yang, Dong, Zhai, Yonggong, Komatsu, Takuo, Tsuruta, Fuminori, Li, Haitao, Cao, Cheng, Li, Wei, Li, Guo-Hong, Cheng, Yifan, Chiba, Tomoki, Wang, Linfang, Goldberg, Alfred L., Shen, Yan, Qiu, Xiao-Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation adenosine triphosphate Amino Acid Sequence Animals chromatin DNA Breaks, Double-Stranded DNA damage DNA Repair epigenetics gene expression regulation histones Histones - metabolism Humans Male Mice Molecular Sequence Data Nuclear Proteins - chemistry Nuclear Proteins - metabolism Proteasome Endopeptidase Complex - metabolism Protein Structure, Tertiary proteolysis Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism Sequence Alignment spermatids Spermatogenesis testes Testis - metabolism yeasts
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