Gene expression profile regulated by the HPV16 E7 oncoprotein and estradiol in cervical tissue
Abstract The HPV16 E7 oncoprotein and 17β-estradiol are important factors for the induction of premalignant lesions and cervical cancer. The study of these factors is crucial for a better understanding of cervical tumorigenesis. Here, we assessed the global gene expression profiles induced by the HP...
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| Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 2013-12, Vol.447 (1), p.155-165 |
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| creator | Cortés-Malagón, Enoc M Bonilla-Delgado, José Díaz-Chávez, José Hidalgo-Miranda, Alfredo Romero-Cordoba, Sandra Üren, Aykut Çelik, Haydar McCormick, Matthew Munguía-Moreno, José A Ibarra-Sierra, Eloisa Escobar-Herrera, Jaime Lambert, Paul F Mendoza-Villanueva, Daniel Bermudez-Cruz, Rosa M Gariglio, Patricio |
| description | Abstract The HPV16 E7 oncoprotein and 17β-estradiol are important factors for the induction of premalignant lesions and cervical cancer. The study of these factors is crucial for a better understanding of cervical tumorigenesis. Here, we assessed the global gene expression profiles induced by the HPV16 E7 oncoprotein and/or 17β-estradiol in cervical tissue of FvB and K14E7 transgenic mice. We found that the most dramatic changes in gene expression occurred in K14E7 and FvB groups treated with 17β-estradiol. A large number of differentially expressed genes involved in the immune response were observed in 17β-estradiol treated groups. The E7 oncoprotein mainly affected the expression of genes involved in cellular metabolism. Our microarray data also identified differentially expressed genes that have not previously been reported in cervical cancer. The identification of genes regulated by E7 and 17β-estradiol, provides the basis for further studies on their role in cervical carcinogenesis. |
| doi_str_mv | 10.1016/j.virol.2013.08.036 |
| format | Article |
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The study of these factors is crucial for a better understanding of cervical tumorigenesis. Here, we assessed the global gene expression profiles induced by the HPV16 E7 oncoprotein and/or 17β-estradiol in cervical tissue of FvB and K14E7 transgenic mice. We found that the most dramatic changes in gene expression occurred in K14E7 and FvB groups treated with 17β-estradiol. A large number of differentially expressed genes involved in the immune response were observed in 17β-estradiol treated groups. The E7 oncoprotein mainly affected the expression of genes involved in cellular metabolism. Our microarray data also identified differentially expressed genes that have not previously been reported in cervical cancer. The identification of genes regulated by E7 and 17β-estradiol, provides the basis for further studies on their role in cervical carcinogenesis.</description><identifier>ISSN: 0042-6822</identifier><identifier>EISSN: 1096-0341</identifier><identifier>DOI: 10.1016/j.virol.2013.08.036</identifier><identifier>PMID: 24210110</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>17β-estradiol ; Animals ; Carcinogenesis ; Cervix ; Estradiol - pharmacology ; Estrogens - pharmacology ; Female ; Gene Expression Profiling ; Gene Expression Regulation - drug effects ; Host-Pathogen Interactions ; HPV16 E7 ; Human papillomavirus 16 ; Infectious Disease ; K14E7 ; Mice ; Mice, Transgenic ; Microarrays ; Papillomavirus E7 Proteins - metabolism</subject><ispartof>Virology (New York, N.Y.), 2013-12, Vol.447 (1), p.155-165</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><rights>2013 Elsevier Inc. All rights reserved. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-2171eaae68152a70b32635bb5a53807e5b41ff2a6aba66e77f8e707f0cfab6a03</citedby><cites>FETCH-LOGICAL-c547t-2171eaae68152a70b32635bb5a53807e5b41ff2a6aba66e77f8e707f0cfab6a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0042682213005096$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24210110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cortés-Malagón, Enoc M</creatorcontrib><creatorcontrib>Bonilla-Delgado, José</creatorcontrib><creatorcontrib>Díaz-Chávez, José</creatorcontrib><creatorcontrib>Hidalgo-Miranda, Alfredo</creatorcontrib><creatorcontrib>Romero-Cordoba, Sandra</creatorcontrib><creatorcontrib>Üren, Aykut</creatorcontrib><creatorcontrib>Çelik, Haydar</creatorcontrib><creatorcontrib>McCormick, Matthew</creatorcontrib><creatorcontrib>Munguía-Moreno, José A</creatorcontrib><creatorcontrib>Ibarra-Sierra, Eloisa</creatorcontrib><creatorcontrib>Escobar-Herrera, Jaime</creatorcontrib><creatorcontrib>Lambert, Paul F</creatorcontrib><creatorcontrib>Mendoza-Villanueva, Daniel</creatorcontrib><creatorcontrib>Bermudez-Cruz, Rosa M</creatorcontrib><creatorcontrib>Gariglio, Patricio</creatorcontrib><title>Gene expression profile regulated by the HPV16 E7 oncoprotein and estradiol in cervical tissue</title><title>Virology (New York, N.Y.)</title><addtitle>Virology</addtitle><description>Abstract The HPV16 E7 oncoprotein and 17β-estradiol are important factors for the induction of premalignant lesions and cervical cancer. The study of these factors is crucial for a better understanding of cervical tumorigenesis. Here, we assessed the global gene expression profiles induced by the HPV16 E7 oncoprotein and/or 17β-estradiol in cervical tissue of FvB and K14E7 transgenic mice. We found that the most dramatic changes in gene expression occurred in K14E7 and FvB groups treated with 17β-estradiol. A large number of differentially expressed genes involved in the immune response were observed in 17β-estradiol treated groups. The E7 oncoprotein mainly affected the expression of genes involved in cellular metabolism. Our microarray data also identified differentially expressed genes that have not previously been reported in cervical cancer. The identification of genes regulated by E7 and 17β-estradiol, provides the basis for further studies on their role in cervical carcinogenesis.</description><subject>17β-estradiol</subject><subject>Animals</subject><subject>Carcinogenesis</subject><subject>Cervix</subject><subject>Estradiol - pharmacology</subject><subject>Estrogens - pharmacology</subject><subject>Female</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Host-Pathogen Interactions</subject><subject>HPV16 E7</subject><subject>Human papillomavirus 16</subject><subject>Infectious Disease</subject><subject>K14E7</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Microarrays</subject><subject>Papillomavirus E7 Proteins - metabolism</subject><issn>0042-6822</issn><issn>1096-0341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl9vFCEUxYnR2LX6CUwMj77MeIEZmD7YxDS1NWmiiX8eJQxzp2VlYYWZjfvtZdy2qb74RIBzzz3wu4S8ZFAzYPLNut65FH3NgYkauhqEfERWDE5kBaJhj8kKoOGV7Dg_Is9yXkPZKwVPyRFveLFgsCLfLzAgxV_bhDm7GOg2xdF5pAmvZ28mHGi_p9MN0stP35ik54rGYGNRTegCNWGgmKdkBhc9LQcW085Z4-nkcp7xOXkyGp_xxe16TL6-P_9ydlldfbz4cPbuqrJto6aKM8XQGJQda7lR0AsuRdv3rWlFBwrbvmHjyI00vZESlRo7VKBGsKPppQFxTE4Pvtu53-BgMZRMXm-T25i019E4_fdNcDf6Ou60OOl4p3gxeH1rkOLPuTxJb1y26L0JGOesSy4QHSupilQcpDbFnBOO920Y6IWMXus_ZPRCRkOnC5lS9ephwvuaOxRF8PYgwPJPO4dJZ-swWBxcQjvpIbr_NDj9p956FxYWP3CPeR3nFAoCzXTmGvTnZTiW2WACoC1DI34Dpbm2yQ</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Cortés-Malagón, Enoc M</creator><creator>Bonilla-Delgado, José</creator><creator>Díaz-Chávez, José</creator><creator>Hidalgo-Miranda, Alfredo</creator><creator>Romero-Cordoba, Sandra</creator><creator>Üren, Aykut</creator><creator>Çelik, Haydar</creator><creator>McCormick, Matthew</creator><creator>Munguía-Moreno, José A</creator><creator>Ibarra-Sierra, Eloisa</creator><creator>Escobar-Herrera, Jaime</creator><creator>Lambert, Paul F</creator><creator>Mendoza-Villanueva, Daniel</creator><creator>Bermudez-Cruz, Rosa M</creator><creator>Gariglio, Patricio</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20131201</creationdate><title>Gene expression profile regulated by the HPV16 E7 oncoprotein and estradiol in cervical tissue</title><author>Cortés-Malagón, Enoc M ; 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The identification of genes regulated by E7 and 17β-estradiol, provides the basis for further studies on their role in cervical carcinogenesis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24210110</pmid><doi>10.1016/j.virol.2013.08.036</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Virology (New York, N.Y.), 2013-12, Vol.447 (1), p.155-165 |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 17β-estradiol Animals Carcinogenesis Cervix Estradiol - pharmacology Estrogens - pharmacology Female Gene Expression Profiling Gene Expression Regulation - drug effects Host-Pathogen Interactions HPV16 E7 Human papillomavirus 16 Infectious Disease K14E7 Mice Mice, Transgenic Microarrays Papillomavirus E7 Proteins - metabolism |
| title | Gene expression profile regulated by the HPV16 E7 oncoprotein and estradiol in cervical tissue |
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