MicroRNA-29b Inhibits Diabetic Nephropathy in db/db Mice

Inflammation and its consequent fibrosis are two main features of diabetic nephropathy (DN), but target therapy on these processes for DN remains yet ineffective. We report here that miR-29b is a novel therapeutic agent capable of inhibiting progressive renal inflammation and fibrosis in type 2 diab...

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Veröffentlicht in:	Molecular therapy 2014-04, Vol.22 (4), p.842-853
Hauptverfasser:	Chen, Hai-Yong, Zhong, Xiang, Huang, Xiao R, Meng, Xiao-Ming, You, Yongke, Chung, Arthur CK, Lan, Hui Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animals Collagen Cytokines Diabetes Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - therapy Diabetic Nephropathies - genetics Diabetic Nephropathies - pathology Diabetic Nephropathies - therapy Diabetic nephropathy Disease Models, Animal Fibrosis - genetics Fibrosis - therapy Genetic Therapy Glucose Growth factors Health sciences Humans Inflammation - genetics Inflammation - pathology Inflammation - therapy Kidney diseases Mice MicroRNAs MicroRNAs - genetics MicroRNAs - therapeutic use Original Phosphorylation Signal Transduction Smad3 Protein - genetics Transforming Growth Factor beta - genetics
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