C-Type Natriuretic Peptide Modulates Permeability of the Blood–Brain Barrier

C-type natriuretic peptide (CNP) is abundant in brain and is reported to exert autocrine function in vascular cells, but its effect on blood–brain barrier (BBB) permeability has not been clarified yet. Here, we examined this effect. Transendothelial electrical resistance (TEER) of in vitro BBB model...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2014-04, Vol.34 (4), p.589-596
Hauptverfasser:	Bohara, Manoj, Kambe, Yuki, Nagayama, Tetsuya, Tokimura, Hiroshi, Arita, Kazunori, Miyata, Atsuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - drug effects Astrocytes - metabolism Blood-Brain Barrier - cytology Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Capillary Permeability - drug effects Cattle Cells, Cultured Cyclic GMP - metabolism Cyclic GMP-Dependent Protein Kinases - metabolism Dose-Response Relationship, Drug Electric Impedance Endothelial Cells - drug effects Endothelial Cells - metabolism Fluorescein - pharmacokinetics Fluorometry Gene Expression - drug effects Male Mice Mice, Inbred ICR Models, Biological Natriuretic Peptide, C-Type - pharmacology Original Primary Cell Culture Rats Rats, Sprague-Dawley Zonula Occludens-1 Protein - genetics
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