A novel small molecule HSP90 inhibitor, NXD30001, differentially induces heat shock proteins in nervous tissue in culture and in vivo

Heat shock proteins (HSPs) are attractive therapeutic targets for neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), characterized by aberrant formation of protein aggregates. Although motor neurons have a high threshold for activation of HSP genes, HSP90 inhibitors are effecti...

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Veröffentlicht in:	Cell stress & chaperones 2014-05, Vol.19 (3), p.421-437
Hauptverfasser:	Cha, Jieun R. C., St. Louis, Kyle J. H., Tradewell, Miranda L., Gentil, Benoit J., Minotti, Sandra, Jaffer, Zahara M., Chen, Ruihong, Rubenstein, Allan E., Durham, Heather D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic lateral sclerosis Animals Antibodies Biochemistry Biomedical and Life Sciences Biomedicine Calcium - metabolism Cancer Research Cell Biology Cell Survival - drug effects Cells, Cultured Ganglia, Spinal - drug effects Ganglia, Spinal - metabolism Genetic mutation Green Fluorescent Proteins - metabolism Heat-Shock Proteins - metabolism Homeostasis - drug effects HSP90 Heat-Shock Proteins - antagonists & inhibitors HSP90 Heat-Shock Proteins - metabolism Immunology Inclusion Bodies - metabolism Lactones - administration & dosage Lactones - pharmacokinetics Lactones - pharmacology Liver Mice Mice, Inbred C57BL Mice, Transgenic Mitochondrial Dynamics - drug effects Motor neurons Motor Neurons - drug effects Motor Neurons - metabolism Nerve Tissue - drug effects Nerve Tissue - metabolism Neurons Neurosciences Original Paper Oximes - administration & dosage Oximes - pharmacokinetics Oximes - pharmacology Phosphorylation - drug effects Plasmids Small Molecule Libraries - administration & dosage Small Molecule Libraries - pharmacokinetics Small Molecule Libraries - pharmacology Spinal cord Spinal Cord - drug effects Spinal Cord - metabolism Superoxide Dismutase - metabolism Superoxide Dismutase-1 Tissue Culture Techniques Vehicles
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