Loss of iron triggers PINK1/Parkin-independent mitophagy

In this study, we develop a simple assay to identify mitophagy inducers on the basis of the use of fluorescently tagged mitochondria that undergo a colour change on lysosomal delivery. Using this assay, we identify iron chelators as a family of compounds that generate a strong mitophagy response. Ir...

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Veröffentlicht in:	EMBO reports 2013-12, Vol.14 (12), p.1127-1135
Hauptverfasser:	Allen, George F G, Toth, Rachel, James, John, Ganley, Ian G
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy Cells, Cultured Chelating agents Chelation EMBO21 EMBO24 Fibroblasts Fibroblasts - drug effects Fibroblasts - metabolism Glycolysis HeLa Cells Humans Iron Iron Chelating Agents - pharmacology Iron Deficiencies iron/mitophagy Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitophagy Movement disorders Mutation Neurodegeneration Neurodegenerative diseases Neurological disorders Parkin Parkin protein Parkinson's disease PINK1 Protein Kinases - metabolism PTEN-induced putative kinase Scientific Report Scientific Reports Studies Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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