Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

Exercise can improve cognitive function and has been linked to the increased expression of brain-derived neurotrophic factor (BDNF). However, the underlying molecular mechanisms driving the elevation of this neurotrophin remain unknown. Here we show that FNDC5, a previously identified muscle protein...

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Veröffentlicht in:	Cell metabolism 2013-11, Vol.18 (5), p.649-659
Hauptverfasser:	Wrann, Christiane D., White, James P., Salogiannnis, John, Laznik-Bogoslavski, Dina, Wu, Jun, Ma, Di, Lin, Jiandie D., Greenberg, Michael E., Spiegelman, Bruce M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Animals Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism ERRalpha Estrogen-Related Receptor Feedback, Physiological - drug effects Fibronectins - genetics Fibronectins - metabolism Gene Expression Profiling Gene Expression Regulation, Developmental - drug effects Genetic Vectors - metabolism Hippocampus - drug effects Hippocampus - metabolism Humans Male Mice Mice, Inbred C57BL Neurons - drug effects Neurons - metabolism Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Physical Conditioning, Animal Protein Binding - drug effects Receptors, Estrogen - metabolism Recombinant Proteins - pharmacology Signal Transduction - drug effects Signal Transduction - genetics Transcription Factors - metabolism
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