Mechanisms of muscle growth and atrophy in mammals and Drosophila
Background: The loss of skeletal muscle mass (atrophy) that accompanies disuse and systemic diseases is highly debilitating. Although the pathogenesis of this condition has been primarily studied in mammals, Drosophila is emerging as an attractive system to investigate some of the mechanisms involve...
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| Veröffentlicht in: | Developmental dynamics 2014-02, Vol.243 (2), p.201-215 |
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| creator | Piccirillo, Rosanna Demontis, Fabio Perrimon, Norbert Goldberg, Alfred L. |
| description | Background: The loss of skeletal muscle mass (atrophy) that accompanies disuse and systemic diseases is highly debilitating. Although the pathogenesis of this condition has been primarily studied in mammals, Drosophila is emerging as an attractive system to investigate some of the mechanisms involved in muscle growth and atrophy. Results: In this review, we highlight the outstanding unsolved questions that may benefit from a combination of studies in both flies and mammals. In particular, we discuss how different environmental stimuli and signaling pathways influence muscle mass and strength and how a variety of disease states can cause muscle wasting. Conclusions: Studies in Drosophila and mammals should help identify molecular targets for the treatment of muscle wasting in humans. Developmental Dynamics 243:201–215, 2014. © 2013 Wiley Periodicals, Inc.
Key Findings
Modulation of muscle mass by environmental stimuli and transcription factors during disease states
Role of protein synthesis and degradation pathways in muscle atrophy
Mammals and Drosophila are useful model organisms to identify the molecular and cellular mechanisms responsible for muscle growth and atrophy in humans |
| doi_str_mv | 10.1002/dvdy.24036 |
| format | Article |
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Key Findings
Modulation of muscle mass by environmental stimuli and transcription factors during disease states
Role of protein synthesis and degradation pathways in muscle atrophy
Mammals and Drosophila are useful model organisms to identify the molecular and cellular mechanisms responsible for muscle growth and atrophy in humans</description><identifier>ISSN: 1058-8388</identifier><identifier>ISSN: 1097-0177</identifier><identifier>EISSN: 1097-0177</identifier><identifier>DOI: 10.1002/dvdy.24036</identifier><identifier>PMID: 24038488</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>animal models of muscle wasting ; Animals ; Drosophila - physiology ; Inflammation - physiopathology ; Mammals - physiology ; Models, Animal ; Models, Biological ; muscle atrophy ; Muscle Development - physiology ; Muscular Atrophy - physiopathology ; Myostatin - metabolism ; Neurodegenerative Diseases - physiopathology ; Oxidative Stress - physiology ; Proteolysis ; proteostasis ; Signal Transduction - physiology ; skeletal muscle growth ; Transcription Factors - metabolism</subject><ispartof>Developmental dynamics, 2014-02, Vol.243 (2), p.201-215</ispartof><rights>Copyright © 2013 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5146-aa630d35a1332c422fb5959972f7298d34754d4688a74fc6ec4cbd4c5b3b2083</citedby><cites>FETCH-LOGICAL-c5146-aa630d35a1332c422fb5959972f7298d34754d4688a74fc6ec4cbd4c5b3b2083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fdvdy.24036$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fdvdy.24036$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1416,1432,27922,27923,45572,45573,46407,46831</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24038488$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Piccirillo, Rosanna</creatorcontrib><creatorcontrib>Demontis, Fabio</creatorcontrib><creatorcontrib>Perrimon, Norbert</creatorcontrib><creatorcontrib>Goldberg, Alfred L.</creatorcontrib><title>Mechanisms of muscle growth and atrophy in mammals and Drosophila</title><title>Developmental dynamics</title><addtitle>Dev Dyn</addtitle><description>Background: The loss of skeletal muscle mass (atrophy) that accompanies disuse and systemic diseases is highly debilitating. Although the pathogenesis of this condition has been primarily studied in mammals, Drosophila is emerging as an attractive system to investigate some of the mechanisms involved in muscle growth and atrophy. Results: In this review, we highlight the outstanding unsolved questions that may benefit from a combination of studies in both flies and mammals. In particular, we discuss how different environmental stimuli and signaling pathways influence muscle mass and strength and how a variety of disease states can cause muscle wasting. Conclusions: Studies in Drosophila and mammals should help identify molecular targets for the treatment of muscle wasting in humans. Developmental Dynamics 243:201–215, 2014. © 2013 Wiley Periodicals, Inc.
Key Findings
Modulation of muscle mass by environmental stimuli and transcription factors during disease states
Role of protein synthesis and degradation pathways in muscle atrophy
Mammals and Drosophila are useful model organisms to identify the molecular and cellular mechanisms responsible for muscle growth and atrophy in humans</description><subject>animal models of muscle wasting</subject><subject>Animals</subject><subject>Drosophila - physiology</subject><subject>Inflammation - physiopathology</subject><subject>Mammals - physiology</subject><subject>Models, Animal</subject><subject>Models, Biological</subject><subject>muscle atrophy</subject><subject>Muscle Development - physiology</subject><subject>Muscular Atrophy - physiopathology</subject><subject>Myostatin - metabolism</subject><subject>Neurodegenerative Diseases - physiopathology</subject><subject>Oxidative Stress - physiology</subject><subject>Proteolysis</subject><subject>proteostasis</subject><subject>Signal Transduction - physiology</subject><subject>skeletal muscle growth</subject><subject>Transcription Factors - metabolism</subject><issn>1058-8388</issn><issn>1097-0177</issn><issn>1097-0177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1LwzAchoMobk4v_gFS8CJCZ76aphdhbH7BxMsQPIU0TbeOtpnJurH_3nSbQz14Snjz8PD75QXgEsE-ghDfZats08cUEnYEuggmcQhRHB-394iHnHDeAWfOzSGEnFF0CjotzCnnXTB41Wom68JVLjB5UDVOlTqYWrNezgJZZ4FcWrOYbYKiDipZVbJ023hkjfN5UcpzcJL7VF_szx6YPD5Mhs_h-O3pZTgYhypClIVSMgIzEklECFYU4zyNkihJYpzHOOEZoXFEM8o4lzHNFdOKqjSjKkpJiiEnPXC_0y6atNKZ0vXSylIsbFFJuxFGFuL3S13MxNSsBEk4pJx6wc1eYM1no91SVIVTuixlrU3jBKIJggwixDx6_Qedm8bWfruWgoxElGBP3e4o5f_CWZ0fhkFQtMWIthixLcbDVz_HP6DfTXgA7YB1UerNPyoxeh997KRfK8mYLg</recordid><startdate>201402</startdate><enddate>201402</enddate><creator>Piccirillo, Rosanna</creator><creator>Demontis, Fabio</creator><creator>Perrimon, Norbert</creator><creator>Goldberg, Alfred L.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>JQ2</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201402</creationdate><title>Mechanisms of muscle growth and atrophy in mammals and Drosophila</title><author>Piccirillo, Rosanna ; Demontis, Fabio ; Perrimon, Norbert ; Goldberg, Alfred L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5146-aa630d35a1332c422fb5959972f7298d34754d4688a74fc6ec4cbd4c5b3b2083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>animal models of muscle wasting</topic><topic>Animals</topic><topic>Drosophila - physiology</topic><topic>Inflammation - physiopathology</topic><topic>Mammals - physiology</topic><topic>Models, Animal</topic><topic>Models, Biological</topic><topic>muscle atrophy</topic><topic>Muscle Development - physiology</topic><topic>Muscular Atrophy - physiopathology</topic><topic>Myostatin - metabolism</topic><topic>Neurodegenerative Diseases - physiopathology</topic><topic>Oxidative Stress - physiology</topic><topic>Proteolysis</topic><topic>proteostasis</topic><topic>Signal Transduction - physiology</topic><topic>skeletal muscle growth</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Piccirillo, Rosanna</creatorcontrib><creatorcontrib>Demontis, Fabio</creatorcontrib><creatorcontrib>Perrimon, Norbert</creatorcontrib><creatorcontrib>Goldberg, Alfred L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Developmental dynamics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Piccirillo, Rosanna</au><au>Demontis, Fabio</au><au>Perrimon, Norbert</au><au>Goldberg, Alfred L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanisms of muscle growth and atrophy in mammals and Drosophila</atitle><jtitle>Developmental dynamics</jtitle><addtitle>Dev Dyn</addtitle><date>2014-02</date><risdate>2014</risdate><volume>243</volume><issue>2</issue><spage>201</spage><epage>215</epage><pages>201-215</pages><issn>1058-8388</issn><issn>1097-0177</issn><eissn>1097-0177</eissn><abstract>Background: The loss of skeletal muscle mass (atrophy) that accompanies disuse and systemic diseases is highly debilitating. Although the pathogenesis of this condition has been primarily studied in mammals, Drosophila is emerging as an attractive system to investigate some of the mechanisms involved in muscle growth and atrophy. Results: In this review, we highlight the outstanding unsolved questions that may benefit from a combination of studies in both flies and mammals. In particular, we discuss how different environmental stimuli and signaling pathways influence muscle mass and strength and how a variety of disease states can cause muscle wasting. Conclusions: Studies in Drosophila and mammals should help identify molecular targets for the treatment of muscle wasting in humans. Developmental Dynamics 243:201–215, 2014. © 2013 Wiley Periodicals, Inc.
Key Findings
Modulation of muscle mass by environmental stimuli and transcription factors during disease states
Role of protein synthesis and degradation pathways in muscle atrophy
Mammals and Drosophila are useful model organisms to identify the molecular and cellular mechanisms responsible for muscle growth and atrophy in humans</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>24038488</pmid><doi>10.1002/dvdy.24036</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Wiley Free Content; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | animal models of muscle wasting Animals Drosophila - physiology Inflammation - physiopathology Mammals - physiology Models, Animal Models, Biological muscle atrophy Muscle Development - physiology Muscular Atrophy - physiopathology Myostatin - metabolism Neurodegenerative Diseases - physiopathology Oxidative Stress - physiology Proteolysis proteostasis Signal Transduction - physiology skeletal muscle growth Transcription Factors - metabolism |
| title | Mechanisms of muscle growth and atrophy in mammals and Drosophila |
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