Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans

Studies in animal models have shown that traumatic brain injury (TBI) induces the rapid accumulation of many of the same key proteins that form pathologic aggregates in neurodegenerative diseases. Here, we examined whether this rapid process also occurs in humans after TBI. Brain tissue from 18 case...

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Veröffentlicht in:	Experimental neurology 2007-12, Vol.208 (2), p.185-192
Hauptverfasser:	Uryu, Kunihiro, Chen, Xiao-Han, Martinez, Dan, Browne, Kevin D., Johnson, Victoria E., Graham, David I., Lee, Virginia M.-Y., Trojanowski, John Q., Smith, Douglas H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Amyloid β APP Axonal injury Axons - metabolism Axons - pathology BACE Biological and medical sciences Brain - metabolism Brain - pathology Brain Injuries - metabolism Brain Injuries - pathology Cadaver Humans Immunohistochemistry Medical sciences Middle Aged Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Nerve Tissue Proteins - metabolism Neurodegenerative Diseases - metabolism Neurology PS-1 Tau TBI Tissue Distribution Traumatic brain injury α-Synuclein
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