Effects of ball-milling on PLGA polymer and its implication on lansoprazole-loaded nanoparticles
PLGA is a biodegradable polymer utilised widely in pharmaceutical research for the encapsulation of a wide range of drugs as nano particulate systems. This study investigates the impact of rotary ball milling on the physical properties of PLGA and its influence on nanoparticle formation prepared usi...
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| Veröffentlicht in: | Journal of basic and clinical pharmacy 2011-03, Vol.2 (2), p.71-82 |
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| container_title | Journal of basic and clinical pharmacy |
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| creator | Shabir, Anjumn Alhusban, Farhan Perrie, Yvonne Mohammed, Afzal R |
| description | PLGA is a biodegradable polymer utilised widely in pharmaceutical research for the encapsulation of a wide range of drugs as nano particulate systems. This study investigates the impact of rotary ball milling on the physical properties of PLGA and its influence on nanoparticle formation prepared using the solvent displacement technique. By applying mechanical stress to the polymer and altering its physical appearance and molecular weight, the loading of lansoprazole within the nanoparticles was increased to 96%, with a reduction in particle size. The results indicate that rotary ball milling significantly reduces particle size, increases lansoprazole loading and improves the release profile for lansoprazole loaded PLGA nanoparticles. |
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This study investigates the impact of rotary ball milling on the physical properties of PLGA and its influence on nanoparticle formation prepared using the solvent displacement technique. By applying mechanical stress to the polymer and altering its physical appearance and molecular weight, the loading of lansoprazole within the nanoparticles was increased to 96%, with a reduction in particle size. The results indicate that rotary ball milling significantly reduces particle size, increases lansoprazole loading and improves the release profile for lansoprazole loaded PLGA nanoparticles.</description><identifier>ISSN: 0976-0105</identifier><identifier>EISSN: 0976-0113</identifier><identifier>PMID: 24826005</identifier><language>eng</language><publisher>India: Medknow Publications & Media Pvt Ltd</publisher><subject>Original</subject><ispartof>Journal of basic and clinical pharmacy, 2011-03, Vol.2 (2), p.71-82</ispartof><rights>Copyright: © Journal of Basic and Clinical Pharmacy 2011</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979202/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979202/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24826005$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shabir, Anjumn</creatorcontrib><creatorcontrib>Alhusban, Farhan</creatorcontrib><creatorcontrib>Perrie, Yvonne</creatorcontrib><creatorcontrib>Mohammed, Afzal R</creatorcontrib><title>Effects of ball-milling on PLGA polymer and its implication on lansoprazole-loaded nanoparticles</title><title>Journal of basic and clinical pharmacy</title><addtitle>J Basic Clin Pharm</addtitle><description>PLGA is a biodegradable polymer utilised widely in pharmaceutical research for the encapsulation of a wide range of drugs as nano particulate systems. 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| title | Effects of ball-milling on PLGA polymer and its implication on lansoprazole-loaded nanoparticles |
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