Animal models of fibromyalgia
Animal models of disease states are valuable tools for developing new treatments and investigating underlying mechanisms. They should mimic the symptoms and pathology of the disease and importantly be predictive of effective treatments. Fibromyalgia is characterized by chronic widespread pain with a...
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Veröffentlicht in: | Arthritis research & therapy 2013-01, Vol.15 (6), p.222-222 |
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creator | DeSantana, Josimari M da Cruz, Kamilla M L Sluka, Kathleen A |
description | Animal models of disease states are valuable tools for developing new treatments and investigating underlying mechanisms. They should mimic the symptoms and pathology of the disease and importantly be predictive of effective treatments. Fibromyalgia is characterized by chronic widespread pain with associated co-morbid symptoms that include fatigue, depression, anxiety and sleep dysfunction. In this review, we present different animal models that mimic the signs and symptoms of fibromyalgia. These models are induced by a wide variety of methods that include repeated muscle insults, depletion of biogenic amines, and stress. All potential models produce widespread and long-lasting hyperalgesia without overt peripheral tissue damage and thus mimic the clinical presentation of fibromyalgia. We describe the methods for induction of the model, pathophysiological mechanisms for each model, and treatment profiles. |
doi_str_mv | 10.1186/ar4402 |
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They should mimic the symptoms and pathology of the disease and importantly be predictive of effective treatments. Fibromyalgia is characterized by chronic widespread pain with associated co-morbid symptoms that include fatigue, depression, anxiety and sleep dysfunction. In this review, we present different animal models that mimic the signs and symptoms of fibromyalgia. These models are induced by a wide variety of methods that include repeated muscle insults, depletion of biogenic amines, and stress. All potential models produce widespread and long-lasting hyperalgesia without overt peripheral tissue damage and thus mimic the clinical presentation of fibromyalgia. We describe the methods for induction of the model, pathophysiological mechanisms for each model, and treatment profiles.</description><identifier>ISSN: 1478-6354</identifier><identifier>EISSN: 1478-6362</identifier><identifier>DOI: 10.1186/ar4402</identifier><identifier>PMID: 24314231</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Animals ; Disease Models, Animal ; Fibromyalgia ; Review</subject><ispartof>Arthritis research & therapy, 2013-01, Vol.15 (6), p.222-222</ispartof><rights>Copyright © 2013 BioMed Central Ltd. 2013 BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b512t-20e9292a00046fc22b11d59fb8568e7feb70eb86ac88bddda36a9b2d33671d0f3</citedby><cites>FETCH-LOGICAL-b512t-20e9292a00046fc22b11d59fb8568e7feb70eb86ac88bddda36a9b2d33671d0f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979153/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979153/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24314231$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DeSantana, Josimari M</creatorcontrib><creatorcontrib>da Cruz, Kamilla M L</creatorcontrib><creatorcontrib>Sluka, Kathleen A</creatorcontrib><title>Animal models of fibromyalgia</title><title>Arthritis research & therapy</title><addtitle>Arthritis Res Ther</addtitle><description>Animal models of disease states are valuable tools for developing new treatments and investigating underlying mechanisms. They should mimic the symptoms and pathology of the disease and importantly be predictive of effective treatments. Fibromyalgia is characterized by chronic widespread pain with associated co-morbid symptoms that include fatigue, depression, anxiety and sleep dysfunction. In this review, we present different animal models that mimic the signs and symptoms of fibromyalgia. These models are induced by a wide variety of methods that include repeated muscle insults, depletion of biogenic amines, and stress. All potential models produce widespread and long-lasting hyperalgesia without overt peripheral tissue damage and thus mimic the clinical presentation of fibromyalgia. We describe the methods for induction of the model, pathophysiological mechanisms for each model, and treatment profiles.</description><subject>Animals</subject><subject>Disease Models, Animal</subject><subject>Fibromyalgia</subject><subject>Review</subject><issn>1478-6354</issn><issn>1478-6362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctKAzEUhoMotlZ9A6UrcTOa22SSjVCKNyi40XVIJkmNZCY1aYW-vVOmVrtwdQ6c_3z_uQBwjuANQpzdqkQpxAdgiGjFC0YYPtzlJR2Ak5w_IMRYYHoMBpgSRDFBQ3AxaX2jwriJxoY8jm7svE6xWasw9-oUHDkVsj3bxhF4e7h_nT4Vs5fH5-lkVugS4WWBoRUdWUEIKXM1xhohUwqnecm4rZzVFbSaM1Vzro0xijAlNDaEsAoZ6MgI3PXcxUo31tS2XSYV5CJ1s6W1jMrL_Urr3-U8fkkiKoFK0gFED9A-_gPYr9Sxkf3Nut7rrXmKnyubl7LxubYhqNbGVZaohIwiQauNzVUvrVPMOVm3c0BQbv7wy7z8u9BO9nN48g0JQoPF</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>DeSantana, Josimari M</creator><creator>da Cruz, Kamilla M L</creator><creator>Sluka, Kathleen A</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130101</creationdate><title>Animal models of fibromyalgia</title><author>DeSantana, Josimari M ; da Cruz, Kamilla M L ; Sluka, Kathleen A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b512t-20e9292a00046fc22b11d59fb8568e7feb70eb86ac88bddda36a9b2d33671d0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Disease Models, Animal</topic><topic>Fibromyalgia</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DeSantana, Josimari M</creatorcontrib><creatorcontrib>da Cruz, Kamilla M L</creatorcontrib><creatorcontrib>Sluka, Kathleen A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Arthritis research & therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DeSantana, Josimari M</au><au>da Cruz, Kamilla M L</au><au>Sluka, Kathleen A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Animal models of fibromyalgia</atitle><jtitle>Arthritis research & therapy</jtitle><addtitle>Arthritis Res Ther</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>15</volume><issue>6</issue><spage>222</spage><epage>222</epage><pages>222-222</pages><issn>1478-6354</issn><eissn>1478-6362</eissn><abstract>Animal models of disease states are valuable tools for developing new treatments and investigating underlying mechanisms. 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source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; Springer Nature OA Free Journals; PubMed Central; SpringerLink Journals - AutoHoldings |
subjects | Animals Disease Models, Animal Fibromyalgia Review |
title | Animal models of fibromyalgia |
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