Animal models of fibromyalgia

Animal models of disease states are valuable tools for developing new treatments and investigating underlying mechanisms. They should mimic the symptoms and pathology of the disease and importantly be predictive of effective treatments. Fibromyalgia is characterized by chronic widespread pain with a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Arthritis research & therapy 2013-01, Vol.15 (6), p.222-222
Hauptverfasser: DeSantana, Josimari M, da Cruz, Kamilla M L, Sluka, Kathleen A
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 222
container_issue 6
container_start_page 222
container_title Arthritis research & therapy
container_volume 15
creator DeSantana, Josimari M
da Cruz, Kamilla M L
Sluka, Kathleen A
description Animal models of disease states are valuable tools for developing new treatments and investigating underlying mechanisms. They should mimic the symptoms and pathology of the disease and importantly be predictive of effective treatments. Fibromyalgia is characterized by chronic widespread pain with associated co-morbid symptoms that include fatigue, depression, anxiety and sleep dysfunction. In this review, we present different animal models that mimic the signs and symptoms of fibromyalgia. These models are induced by a wide variety of methods that include repeated muscle insults, depletion of biogenic amines, and stress. All potential models produce widespread and long-lasting hyperalgesia without overt peripheral tissue damage and thus mimic the clinical presentation of fibromyalgia. We describe the methods for induction of the model, pathophysiological mechanisms for each model, and treatment profiles.
doi_str_mv 10.1186/ar4402
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3979153</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1506419473</sourcerecordid><originalsourceid>FETCH-LOGICAL-b512t-20e9292a00046fc22b11d59fb8568e7feb70eb86ac88bddda36a9b2d33671d0f3</originalsourceid><addsrcrecordid>eNp1kctKAzEUhoMotlZ9A6UrcTOa22SSjVCKNyi40XVIJkmNZCY1aYW-vVOmVrtwdQ6c_3z_uQBwjuANQpzdqkQpxAdgiGjFC0YYPtzlJR2Ak5w_IMRYYHoMBpgSRDFBQ3AxaX2jwriJxoY8jm7svE6xWasw9-oUHDkVsj3bxhF4e7h_nT4Vs5fH5-lkVugS4WWBoRUdWUEIKXM1xhohUwqnecm4rZzVFbSaM1Vzro0xijAlNDaEsAoZ6MgI3PXcxUo31tS2XSYV5CJ1s6W1jMrL_Urr3-U8fkkiKoFK0gFED9A-_gPYr9Sxkf3Nut7rrXmKnyubl7LxubYhqNbGVZaohIwiQauNzVUvrVPMOVm3c0BQbv7wy7z8u9BO9nN48g0JQoPF</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1506419473</pqid></control><display><type>article</type><title>Animal models of fibromyalgia</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central Open Access</source><source>Springer Nature OA Free Journals</source><source>PubMed Central</source><source>SpringerLink Journals - AutoHoldings</source><creator>DeSantana, Josimari M ; da Cruz, Kamilla M L ; Sluka, Kathleen A</creator><creatorcontrib>DeSantana, Josimari M ; da Cruz, Kamilla M L ; Sluka, Kathleen A</creatorcontrib><description>Animal models of disease states are valuable tools for developing new treatments and investigating underlying mechanisms. They should mimic the symptoms and pathology of the disease and importantly be predictive of effective treatments. Fibromyalgia is characterized by chronic widespread pain with associated co-morbid symptoms that include fatigue, depression, anxiety and sleep dysfunction. In this review, we present different animal models that mimic the signs and symptoms of fibromyalgia. These models are induced by a wide variety of methods that include repeated muscle insults, depletion of biogenic amines, and stress. All potential models produce widespread and long-lasting hyperalgesia without overt peripheral tissue damage and thus mimic the clinical presentation of fibromyalgia. We describe the methods for induction of the model, pathophysiological mechanisms for each model, and treatment profiles.</description><identifier>ISSN: 1478-6354</identifier><identifier>EISSN: 1478-6362</identifier><identifier>DOI: 10.1186/ar4402</identifier><identifier>PMID: 24314231</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Animals ; Disease Models, Animal ; Fibromyalgia ; Review</subject><ispartof>Arthritis research &amp; therapy, 2013-01, Vol.15 (6), p.222-222</ispartof><rights>Copyright © 2013 BioMed Central Ltd. 2013 BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b512t-20e9292a00046fc22b11d59fb8568e7feb70eb86ac88bddda36a9b2d33671d0f3</citedby><cites>FETCH-LOGICAL-b512t-20e9292a00046fc22b11d59fb8568e7feb70eb86ac88bddda36a9b2d33671d0f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979153/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979153/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24314231$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DeSantana, Josimari M</creatorcontrib><creatorcontrib>da Cruz, Kamilla M L</creatorcontrib><creatorcontrib>Sluka, Kathleen A</creatorcontrib><title>Animal models of fibromyalgia</title><title>Arthritis research &amp; therapy</title><addtitle>Arthritis Res Ther</addtitle><description>Animal models of disease states are valuable tools for developing new treatments and investigating underlying mechanisms. They should mimic the symptoms and pathology of the disease and importantly be predictive of effective treatments. Fibromyalgia is characterized by chronic widespread pain with associated co-morbid symptoms that include fatigue, depression, anxiety and sleep dysfunction. In this review, we present different animal models that mimic the signs and symptoms of fibromyalgia. These models are induced by a wide variety of methods that include repeated muscle insults, depletion of biogenic amines, and stress. All potential models produce widespread and long-lasting hyperalgesia without overt peripheral tissue damage and thus mimic the clinical presentation of fibromyalgia. We describe the methods for induction of the model, pathophysiological mechanisms for each model, and treatment profiles.</description><subject>Animals</subject><subject>Disease Models, Animal</subject><subject>Fibromyalgia</subject><subject>Review</subject><issn>1478-6354</issn><issn>1478-6362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctKAzEUhoMotlZ9A6UrcTOa22SSjVCKNyi40XVIJkmNZCY1aYW-vVOmVrtwdQ6c_3z_uQBwjuANQpzdqkQpxAdgiGjFC0YYPtzlJR2Ak5w_IMRYYHoMBpgSRDFBQ3AxaX2jwriJxoY8jm7svE6xWasw9-oUHDkVsj3bxhF4e7h_nT4Vs5fH5-lkVugS4WWBoRUdWUEIKXM1xhohUwqnecm4rZzVFbSaM1Vzro0xijAlNDaEsAoZ6MgI3PXcxUo31tS2XSYV5CJ1s6W1jMrL_Urr3-U8fkkiKoFK0gFED9A-_gPYr9Sxkf3Nut7rrXmKnyubl7LxubYhqNbGVZaohIwiQauNzVUvrVPMOVm3c0BQbv7wy7z8u9BO9nN48g0JQoPF</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>DeSantana, Josimari M</creator><creator>da Cruz, Kamilla M L</creator><creator>Sluka, Kathleen A</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130101</creationdate><title>Animal models of fibromyalgia</title><author>DeSantana, Josimari M ; da Cruz, Kamilla M L ; Sluka, Kathleen A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b512t-20e9292a00046fc22b11d59fb8568e7feb70eb86ac88bddda36a9b2d33671d0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Disease Models, Animal</topic><topic>Fibromyalgia</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DeSantana, Josimari M</creatorcontrib><creatorcontrib>da Cruz, Kamilla M L</creatorcontrib><creatorcontrib>Sluka, Kathleen A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Arthritis research &amp; therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DeSantana, Josimari M</au><au>da Cruz, Kamilla M L</au><au>Sluka, Kathleen A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Animal models of fibromyalgia</atitle><jtitle>Arthritis research &amp; therapy</jtitle><addtitle>Arthritis Res Ther</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>15</volume><issue>6</issue><spage>222</spage><epage>222</epage><pages>222-222</pages><issn>1478-6354</issn><eissn>1478-6362</eissn><abstract>Animal models of disease states are valuable tools for developing new treatments and investigating underlying mechanisms. They should mimic the symptoms and pathology of the disease and importantly be predictive of effective treatments. Fibromyalgia is characterized by chronic widespread pain with associated co-morbid symptoms that include fatigue, depression, anxiety and sleep dysfunction. In this review, we present different animal models that mimic the signs and symptoms of fibromyalgia. These models are induced by a wide variety of methods that include repeated muscle insults, depletion of biogenic amines, and stress. All potential models produce widespread and long-lasting hyperalgesia without overt peripheral tissue damage and thus mimic the clinical presentation of fibromyalgia. We describe the methods for induction of the model, pathophysiological mechanisms for each model, and treatment profiles.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>24314231</pmid><doi>10.1186/ar4402</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1478-6354
ispartof Arthritis research & therapy, 2013-01, Vol.15 (6), p.222-222
issn 1478-6354
1478-6362
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3979153
source MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; Springer Nature OA Free Journals; PubMed Central; SpringerLink Journals - AutoHoldings
subjects Animals
Disease Models, Animal
Fibromyalgia
Review
title Animal models of fibromyalgia
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T14%3A04%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Animal%20models%20of%20fibromyalgia&rft.jtitle=Arthritis%20research%20&%20therapy&rft.au=DeSantana,%20Josimari%20M&rft.date=2013-01-01&rft.volume=15&rft.issue=6&rft.spage=222&rft.epage=222&rft.pages=222-222&rft.issn=1478-6354&rft.eissn=1478-6362&rft_id=info:doi/10.1186/ar4402&rft_dat=%3Cproquest_pubme%3E1506419473%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1506419473&rft_id=info:pmid/24314231&rfr_iscdi=true