Immunotherapy-induced CD8+ T Cells Instigate Immune Suppression in the Tumor

Despite clear evidence of immunogenicity, cancer vaccines only provide a modest clinical benefit. To evaluate the mechanisms that limit tumor regression following vaccination, we have investigated the weak efficacy of a highly immunogenic experimental vaccine using a murine melanoma model. We discov...

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Veröffentlicht in:	Molecular therapy 2014-01, Vol.22 (1), p.206-218
Hauptverfasser:	McGray, A J Robert, Hallett, Robin, Bernard, Dannie, Swift, Stephanie L, Zhu, Ziqiang, Teoderascu, Florentina, VanSeggelen, Heather, Hassell, John A, Hurwitz, Arthur A, Wan, Yonghong, Bramson, Jonathan L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Adaptive Immunity - genetics Adenoviruses Adenoviruses, Human - genetics Animals Antigens, Neoplasm - genetics Antigens, Neoplasm - immunology Cancer vaccines Cancer Vaccines - immunology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cells Cytokines Female Genetic Vectors - genetics Genetic Vectors - immunology Immunology Immunomodulation - genetics Immunomodulation - immunology Immunotherapy Immunotherapy, Adoptive Interferon-gamma - immunology Interferon-gamma - metabolism Intramolecular Oxidoreductases - genetics Intramolecular Oxidoreductases - immunology Lymphocytes Lymphocytes, Tumor-Infiltrating - immunology Mice Neoplasm Recurrence, Local Neoplasms - genetics Neoplasms - immunology Neoplasms - pathology Neoplasms - therapy Original T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Tumor Burden - genetics Tumor Burden - immunology Tumor necrosis factor-TNF Tumors Vaccination Vaccines, Synthetic
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