Interplay of choline metabolites and genes in patient-derived breast cancer xenografts

Dysregulated choline metabolism is a well-known feature of breast cancer, but the underlying mechanisms are not fully understood. In this study, the metabolomic and transcriptomic characteristics of a large panel of human breast cancer xenograft models were mapped, with focus on choline metabolism....

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Veröffentlicht in:	Breast cancer research : BCR 2014-01, Vol.16 (1), p.R5-R5, Article R5
Hauptverfasser:	Grinde, Maria T, Skrbo, Nirma, Moestue, Siver A, Rødland, Einar A, Borgan, Eldrid, Kristian, Alexandr, Sitter, Beathe, Bathen, Tone F, Børresen-Dale, Anne-Lise, Mælandsmo, Gunhild M, Engebraaten, Olav, Sørlie, Therese, Marangoni, Elisabetta, Gribbestad, Ingrid S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Choline - metabolism Choline Kinase - biosynthesis Choline Kinase - genetics Clinical medical disciplines: 750 Female Gene Expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Glycerylphosphorylcholine - metabolism Humans Klinisk medisinske fag: 750 Medical disciplines: 700 Medisinske Fag: 700 Metabolomics Mice Neoplasm Transplantation Oncology: 762 Onkologi: 762 Phosphoric Diester Hydrolases - biosynthesis Phosphoric Diester Hydrolases - genetics Phosphoric Diester Hydrolases - metabolism Phosphorylcholine - metabolism Tissue Array Analysis Transcriptome Transplantation, Heterologous VDP
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