Intermittent Hypoxia-induced Changes in Tumor-associated Macrophages and Tumor Malignancy in a Mouse Model of Sleep Apnea

An increased cancer aggressiveness and mortality have been recently reported among patients with obstructive sleep apnea (OSA). Intermittent hypoxia (IH), a hallmark of OSA, enhances melanoma growth and metastasis in mice. To assess whether OSA-related adverse cancer outcomes occur via IH-induced ch...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2014-03, Vol.189 (5), p.593-601
Hauptverfasser:	ALMENDROS, Isaac, YANG WANG, FARRE, Ramon, GOZAL, David, BECKER, Lev, LENNON, Frances E, JIAMAO ZHENG, COATS, Brittney R, SCHOENFELT, Kelly S, CARRERAS, Alba, HAKIM, Fahed, ZHANG, Shelley X
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Cancer Cell Line, Tumor Cell Proliferation Disease Models, Animal Flow Cytometry Hypoxia Hypoxia - etiology Hypoxia - immunology Immune system Intensive care medicine Lung Neoplasms - immunology Lung Neoplasms - pathology Macrophages - pathology Male Medical sciences Melanoma Melanoma, Experimental - immunology Melanoma, Experimental - pathology Metastasis Mice Mice, Inbred C57BL Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Invasiveness Original Phenotype Pneumology Proteomics Respiratory system : syndromes and miscellaneous diseases Sleep apnea Sleep Apnea, Obstructive - immunology Sleep Apnea, Obstructive - physiopathology T-Lymphocytes, Cytotoxic - pathology Tumors
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