BDNF secretion by human pulmonary artery endothelial cells in response to hypoxia

Abstract Within human pulmonary artery, neurotrophin growth factors [NTs; e.g. brain-derived neurotrophic factor (BDNF)] and their high-affinity receptors (tropomyosin-related kinase; Trk) and low-affinity receptors p75 neurotrophin receptor (p75NTR) have been reported, but their functional role is...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2014-03, Vol.68, p.89-97
Hauptverfasser:	Helan, Martin, Aravamudan, Bharathi, Hartman, William R, Thompson, Michael A, Johnson, Bruce D, Pabelick, Christina M, Prakash, Y.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Arginase - metabolism Brain-Derived Neurotrophic Factor - blood Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Cardiovascular Cell Hypoxia Cells, Cultured Endothelial Cells - metabolism Endothelium, Vascular - pathology eNOS Gene Expression Humans Hypoxia - blood Hypoxia inducible factor 1 Hypoxia-Inducible Factor 1 - metabolism iNOS Membrane Glycoproteins Neurotrophin Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type II - metabolism Nitric Oxide Synthase Type III - metabolism Protein Kinases - metabolism Protein-Tyrosine Kinases Pulmonary Artery - pathology Receptor, trkB RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction Tropomyosin related kinase
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