Prevention of liver cancer cachexia-induced cardiac wasting and heart failure

Symptoms of cancer cachexia (CC) include fatigue, shortness of breath, and impaired exercise capacity, which are also hallmark symptoms of heart failure (HF). Herein, we evaluate the effects of drugs commonly used to treat HF (bisoprolol, imidapril, spironolactone) on development of cardiac wasting,...

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Veröffentlicht in:	European heart journal 2014-04, Vol.35 (14), p.932-941
Hauptverfasser:	Springer, Jochen, Tschirner, Anika, Haghikia, Arash, von Haehling, Stephan, Lal, Hind, Grzesiak, Aleksandra, Kaschina, Elena, Palus, Sandra, Pötsch, Mareike, von Websky, Karoline, Hocher, Berthold, Latouche, Celine, Jaisser, Frederic, Morawietz, Lars, Coats, Andrew J S, Beadle, John, Argiles, Josep M, Thum, Thomas, Földes, Gabor, Doehner, Wolfram, Hilfiker-Kleiner, Denise, Force, Thomas, Anker, Stefan D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-1 Receptor Antagonists - pharmacology Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Basic Science Bisoprolol - pharmacology Body Composition - drug effects Body Weight - drug effects Cachexia - prevention & control Glycogen Synthase Kinase 3 - metabolism Heart Failure - prevention & control Imidazolidines - pharmacology Liver Neoplasms - prevention & control Mineralocorticoid Receptor Antagonists - pharmacology Myocytes, Cardiac - drug effects Myosin Heavy Chains - drug effects Rats Signal Transduction - drug effects Spironolactone - pharmacology Survival Analysis Ventricular Dysfunction, Left - drug therapy Wasting Syndrome - prevention & control
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