Ligand Concentration Regulates the Pathways of Coupled Protein Folding and Binding

Coupled ligand binding and conformational change plays a central role in biological regulation. Ligands often regulate protein function by modulating conformational dynamics, yet the order in which binding and conformational change occurs are often hotly debated. Here we show that the “conformationa...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of the American Chemical Society 2014-01, Vol.136 (3), p.822-825
Hauptverfasser:	Daniels, Kyle G, Tonthat, Nam K, McClure, David R, Chang, Yu-Chu, Liu, Xin, Schumacher, Maria A, Fierke, Carol A, Schmidler, Scott C, Oas, Terrence G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Bacillus subtilis Bacillus subtilis - enzymology Diphosphates - metabolism Ligands Models, Molecular Protein Binding Protein Conformation Protein Folding Ribonuclease P - chemistry Ribonuclease P - genetics Ribonuclease P - metabolism ribonucleases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!