Reversible Overexpression of Bace1 -Cleaved Neuregulin-1 N -Terminal Fragment Induces Schizophrenia-Like Phenotypes in Mice

Background Neuregulin-1 (Nrg1) is a pleiotropic signaling molecule that regulates neural development, and mutation of Nrg1 is a risk factor for schizophrenia. Cleavage of type I β1 Nrg1 isoform by Bace1 releases a secreted N -terminal fragment (Nrg1-ntfβ ), which can bind to a cognate ErbB receptor...

Ausführliche Beschreibung