Genetic Polymorphisms of ORAI1 and Chronic Kidney Disease in Taiwanese Population
Taiwan has very high incidence and prevalence of chronic kidney disease (CKD), which easily progresses to end-stage renal disease (ESRD). The association between inflammation and CKD has been explored in several studies. ORAI1 functions as a pore-forming subunit of the store-operated calcium channel...
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| Veröffentlicht in: | BioMed research international 2014-01, Vol.2014 (2014), p.1-6 |
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| description | Taiwan has very high incidence and prevalence of chronic kidney disease (CKD), which easily progresses to end-stage renal disease (ESRD). The association between inflammation and CKD has been explored in several studies. ORAI1 functions as a pore-forming subunit of the store-operated calcium channels which are involved in the regulation of immune system. Hence, we conducted a case-control study to determine whether the genetic polymorphisms of ORAI1 gene is a susceptibility factor to CKD and its clinical features in a Taiwanese population. Five hundred seventy-nine CKD patients from a hospital-based CKD care program were included in the study. Five tagging single nucleotide polymorphisms (tSNPs) of ORAI1 were selected from the genotyping data of the Han Chinese population from the HapMap project. Among these polymorphisms, rs12313273 was found to be significantly associated with elevated serum calcium levels, which has been linked to increased risk of death in CKD patients. To have a better management of serum calcium, we suggest that ORAI1 polymorphisms might be used as a potential biomarker for initiating non-calcium-based phosphate binder in CKD patients in the future. |
| doi_str_mv | 10.1155/2014/290863 |
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The association between inflammation and CKD has been explored in several studies. ORAI1 functions as a pore-forming subunit of the store-operated calcium channels which are involved in the regulation of immune system. Hence, we conducted a case-control study to determine whether the genetic polymorphisms of ORAI1 gene is a susceptibility factor to CKD and its clinical features in a Taiwanese population. Five hundred seventy-nine CKD patients from a hospital-based CKD care program were included in the study. Five tagging single nucleotide polymorphisms (tSNPs) of ORAI1 were selected from the genotyping data of the Han Chinese population from the HapMap project. Among these polymorphisms, rs12313273 was found to be significantly associated with elevated serum calcium levels, which has been linked to increased risk of death in CKD patients. To have a better management of serum calcium, we suggest that ORAI1 polymorphisms might be used as a potential biomarker for initiating non-calcium-based phosphate binder in CKD patients in the future.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/290863</identifier><identifier>PMID: 24745010</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomedical research ; Calcium channels ; Calcium Channels - genetics ; Cell cycle ; Chronic kidney failure ; Deoxyribonucleic acid ; DNA ; Enzymes ; Female ; Gene expression ; Genetic Markers - genetics ; Genetic Predisposition to Disease - genetics ; Hospitals ; Humans ; Internal medicine ; Kidney diseases ; Male ; Medical treatment ; Medicine ; Middle Aged ; Mortality ; Mutation - genetics ; ORAI1 Protein ; Pharmacy ; Polymorphism, Single Nucleotide - genetics ; Prevalence ; Renal Insufficiency, Chronic - epidemiology ; Renal Insufficiency, Chronic - genetics ; Risk Factors ; Rodents ; Single nucleotide polymorphisms ; Studies ; Taiwan - epidemiology</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-6</ispartof><rights>Copyright © 2014 Daw-Yang Hwang et al.</rights><rights>COPYRIGHT 2014 John Wiley & Sons, Inc.</rights><rights>Copyright © 2014 Daw-Yang Hwang et al. Daw-Yang Hwang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Daw-Yang Hwang et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-ed2462b7e55eb71a21d15d515094bb0aaa5e2c371e0f5d9be6ba2731d2d2b873</citedby><cites>FETCH-LOGICAL-c490t-ed2462b7e55eb71a21d15d515094bb0aaa5e2c371e0f5d9be6ba2731d2d2b873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976823/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976823/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24745010$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Chang, Wei Chiao</contributor><creatorcontrib>Chang, Jer-Ming</creatorcontrib><creatorcontrib>Lu, Hui-Chen</creatorcontrib><creatorcontrib>Cheng, Shih-Ying</creatorcontrib><creatorcontrib>Wu, Mai-Szu</creatorcontrib><creatorcontrib>Kao, Chih-Chin</creatorcontrib><creatorcontrib>Hsu, Yu-Wen</creatorcontrib><creatorcontrib>Hwang, Daw-Yang</creatorcontrib><creatorcontrib>Chien, Shu-Chen</creatorcontrib><title>Genetic Polymorphisms of ORAI1 and Chronic Kidney Disease in Taiwanese Population</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Taiwan has very high incidence and prevalence of chronic kidney disease (CKD), which easily progresses to end-stage renal disease (ESRD). The association between inflammation and CKD has been explored in several studies. ORAI1 functions as a pore-forming subunit of the store-operated calcium channels which are involved in the regulation of immune system. Hence, we conducted a case-control study to determine whether the genetic polymorphisms of ORAI1 gene is a susceptibility factor to CKD and its clinical features in a Taiwanese population. Five hundred seventy-nine CKD patients from a hospital-based CKD care program were included in the study. Five tagging single nucleotide polymorphisms (tSNPs) of ORAI1 were selected from the genotyping data of the Han Chinese population from the HapMap project. Among these polymorphisms, rs12313273 was found to be significantly associated with elevated serum calcium levels, which has been linked to increased risk of death in CKD patients. To have a better management of serum calcium, we suggest that ORAI1 polymorphisms might be used as a potential biomarker for initiating non-calcium-based phosphate binder in CKD patients in the future.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomedical research</subject><subject>Calcium channels</subject><subject>Calcium Channels - genetics</subject><subject>Cell cycle</subject><subject>Chronic kidney failure</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Enzymes</subject><subject>Female</subject><subject>Gene expression</subject><subject>Genetic Markers - genetics</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Internal medicine</subject><subject>Kidney diseases</subject><subject>Male</subject><subject>Medical treatment</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Mutation - genetics</subject><subject>ORAI1 Protein</subject><subject>Pharmacy</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Prevalence</subject><subject>Renal Insufficiency, Chronic - epidemiology</subject><subject>Renal Insufficiency, Chronic - genetics</subject><subject>Risk Factors</subject><subject>Rodents</subject><subject>Single nucleotide polymorphisms</subject><subject>Studies</subject><subject>Taiwan - epidemiology</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqN0s9v0zAUB_AIMbFp7MQZFIkL2lTm55_JBakqMCYmbaDeLSd-WT0ldhcnTP3v5y5bGVzAF9vyR1_5-TnL3gD5CCDEKSXAT2lJCsleZAeUAZ9J4PByt2ZsPzuK8YakUYAkpXyV7VOuuCBADrIfZ-hxcHV-FdpNF_r1ysUu5qHJL3_OzyE33uaLVR98It-d9bjJP7uIJmLufL407s54TJursB5bM7jgX2d7jWkjHj3Oh9ny65fl4tvs4vLsfDG_mNW8JMMMLeWSVgqFwEqBoWBBWAGClLyqiDFGIK2ZAiSNsGWFsjJUMbDU0qpQ7DD7NMWux6pDW6MfetPqde860290ME7_eeLdSl-HX5qVShaUpYAPjwF9uB0xDrpzsca2TQWFMWoQlDAlCZf_QUEVBVMP9P1f9CaMvU8PkZRkSpVQkt_q2rSonW9CumK9DdVzThWhlD9knUyq7kOMPTa76oDobff1tvt66n7S754_yM4-9TqB4wmsnLfmzv0j7e2EMRFszA5zmb4RYfci4r3R</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Chang, Jer-Ming</creator><creator>Lu, Hui-Chen</creator><creator>Cheng, Shih-Ying</creator><creator>Wu, Mai-Szu</creator><creator>Kao, Chih-Chin</creator><creator>Hsu, Yu-Wen</creator><creator>Hwang, Daw-Yang</creator><creator>Chien, Shu-Chen</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20140101</creationdate><title>Genetic Polymorphisms of ORAI1 and Chronic Kidney Disease in Taiwanese Population</title><author>Chang, Jer-Ming ; Lu, Hui-Chen ; Cheng, Shih-Ying ; Wu, Mai-Szu ; Kao, Chih-Chin ; Hsu, Yu-Wen ; Hwang, Daw-Yang ; Chien, Shu-Chen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-ed2462b7e55eb71a21d15d515094bb0aaa5e2c371e0f5d9be6ba2731d2d2b873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomedical research</topic><topic>Calcium channels</topic><topic>Calcium Channels - genetics</topic><topic>Cell cycle</topic><topic>Chronic kidney failure</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Enzymes</topic><topic>Female</topic><topic>Gene expression</topic><topic>Genetic Markers - genetics</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Internal medicine</topic><topic>Kidney diseases</topic><topic>Male</topic><topic>Medical treatment</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Mutation - genetics</topic><topic>ORAI1 Protein</topic><topic>Pharmacy</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Prevalence</topic><topic>Renal Insufficiency, Chronic - epidemiology</topic><topic>Renal Insufficiency, Chronic - genetics</topic><topic>Risk Factors</topic><topic>Rodents</topic><topic>Single nucleotide polymorphisms</topic><topic>Studies</topic><topic>Taiwan - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Jer-Ming</creatorcontrib><creatorcontrib>Lu, Hui-Chen</creatorcontrib><creatorcontrib>Cheng, Shih-Ying</creatorcontrib><creatorcontrib>Wu, Mai-Szu</creatorcontrib><creatorcontrib>Kao, Chih-Chin</creatorcontrib><creatorcontrib>Hsu, Yu-Wen</creatorcontrib><creatorcontrib>Hwang, Daw-Yang</creatorcontrib><creatorcontrib>Chien, Shu-Chen</creatorcontrib><collection>الدوريات العلمية والإحصائية - 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The association between inflammation and CKD has been explored in several studies. ORAI1 functions as a pore-forming subunit of the store-operated calcium channels which are involved in the regulation of immune system. Hence, we conducted a case-control study to determine whether the genetic polymorphisms of ORAI1 gene is a susceptibility factor to CKD and its clinical features in a Taiwanese population. Five hundred seventy-nine CKD patients from a hospital-based CKD care program were included in the study. Five tagging single nucleotide polymorphisms (tSNPs) of ORAI1 were selected from the genotyping data of the Han Chinese population from the HapMap project. Among these polymorphisms, rs12313273 was found to be significantly associated with elevated serum calcium levels, which has been linked to increased risk of death in CKD patients. To have a better management of serum calcium, we suggest that ORAI1 polymorphisms might be used as a potential biomarker for initiating non-calcium-based phosphate binder in CKD patients in the future.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>24745010</pmid><doi>10.1155/2014/290863</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Biomedical research Calcium channels Calcium Channels - genetics Cell cycle Chronic kidney failure Deoxyribonucleic acid DNA Enzymes Female Gene expression Genetic Markers - genetics Genetic Predisposition to Disease - genetics Hospitals Humans Internal medicine Kidney diseases Male Medical treatment Medicine Middle Aged Mortality Mutation - genetics ORAI1 Protein Pharmacy Polymorphism, Single Nucleotide - genetics Prevalence Renal Insufficiency, Chronic - epidemiology Renal Insufficiency, Chronic - genetics Risk Factors Rodents Single nucleotide polymorphisms Studies Taiwan - epidemiology |
| title | Genetic Polymorphisms of ORAI1 and Chronic Kidney Disease in Taiwanese Population |
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