pH-Controlled Two-Step Uncoating of Influenza Virus

Upon endocytosis in its cellular host, influenza A virus transits via early to late endosomes. To efficiently release its genome, the composite viral shell must undergo significant structural rearrangement, but the exact sequence of events leading to viral uncoating remains largely speculative. In a...

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Veröffentlicht in:	Biophysical journal 2014-04, Vol.106 (7), p.1447-1456
Hauptverfasser:	Li, Sai, Sieben, Christian, Ludwig, Kai, Höfer, Chris T., Chiantia, Salvatore, Herrmann, Andreas, Eghiaian, Frederic, Schaap, Iwan A.T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Biophysics Cells Cryoelectron Microscopy Dogs Endosomes - chemistry Endosomes - virology Genome, Viral Genomes Hemagglutinin Glycoproteins, Influenza Virus - chemistry Hydrogen-Ion Concentration Influenza Influenza A virus Influenza A Virus, H3N2 Subtype - chemistry Influenza A Virus, H3N2 Subtype - genetics Influenza A Virus, H3N2 Subtype - physiology Influenza A Virus, H3N2 Subtype - ultrastructure Liposomes - chemistry Madin Darby Canine Kidney Cells Mechanical Phenomena Microscopy, Atomic Force Protein Conformation Protons Ribonucleoproteins - chemistry Viral Matrix Proteins - chemistry Viral Proteins - chemistry Virion - chemistry Virus Uncoating
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