Protective effect of a sesamin derivative, 3-bis (3-methoxybenzyl) butane-1, 4-diol on ischemic and hypoxic neuronal injury

Stroke is one of the leading causes of neuronal death. Sesamin is known for neuroprotection by its antioxidant and anti-inflammatory properties but it lacks blood-brain barrier (BBB) activity. A panel of sesamin derivatives was screened and 3-bis (3-methoxybenzyl) butane-1,4-diol (BBD) was selected...

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Veröffentlicht in:	Journal of biomedical science 2014-02, Vol.21 (1), p.15-15, Article 15
Hauptverfasser:	Hou, Chien-Wei, Chen, Yi-Ling, Chuang, Shih-Hsien, Wang, Jen-Shu, Jeng, Kee-Ching
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - chemistry Antioxidants Antioxidants - administration & dosage Antioxidants - chemistry Antioxidants - metabolism Apoptosis Blood-brain barrier Blood-Brain Barrier - drug effects Brain Ischemia - drug therapy Brain Ischemia - pathology Butane Butylene Glycols - administration & dosage Cell Hypoxia - drug effects COX-2 inhibitors Cytokines Dioxoles - administration & dosage Dioxoles - chemistry Disease Enzyme-linked immunosorbent assay Enzymes Free radicals Glucose Glycols Hospitals Humans Hypoxia Injuries Ischemia Kinases Lignans - administration & dosage Lignans - chemistry Lipid peroxidation Lipid Peroxidation - drug effects Lipids Mice Microglia - drug effects Microglia - pathology Neurons Neurons - drug effects Neurons - pathology Neuroprotective Agents - administration & dosage Neuroprotective Agents - chemistry Older people Oxidative stress Permeability Proteins Rats Reactive Oxygen Species - metabolism Rodents Signal Transduction - drug effects Studies Superoxide Superoxide Dismutase - biosynthesis Veins & arteries
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