Neuropsychiatric correlates of white matter hyperintensities in Alzheimer's disease
Objective To investigate the association of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD) and magnetic resonance imaging (MRI) measures of brain atrophy and white matter hyperintensities (WMH). Methods Thirty‐seven patients with probable AD received the Ne...
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| Veröffentlicht in: | International journal of geriatric psychiatry 2010-08, Vol.25 (8), p.780-788 |
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| container_title | International journal of geriatric psychiatry |
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| creator | Berlow, Yosef A. Wells, William M. Ellison, James M. Sung, Young Hoon Renshaw, Perry F. Harper, David G. |
| description | Objective
To investigate the association of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD) and magnetic resonance imaging (MRI) measures of brain atrophy and white matter hyperintensities (WMH).
Methods
Thirty‐seven patients with probable AD received the Neuropsychiatric Inventory (NPI), the Mini Mental Status Exam (MMSE), and an MRI scan as part of their initial evaluation at the Outpatient Memory Diagnostic Clinic at McLean Hospital. MRI‐based volumetric measurements of whole brain atrophy, hippocampal volumes, and WMH were obtained. Analysis of covariance models, using age as a covariate and the presence of specific BPSD as independent variables, were used to test for differences in whole brain volumes, hippocampal volumes and WMH volumes.
Results
Increased WMH were associated with symptoms of anxiety, aberrant motor behavior, and night time disturbance, while symptoms of disinhibition were linked to lower WMH volume. No associations were found for whole brain or hippocampal volumes and BPSD.
Conclusions
These findings suggest that white matter changes are associated with the presence of BPSD in AD. Copyright © 2009 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/gps.2418 |
| format | Article |
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To investigate the association of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD) and magnetic resonance imaging (MRI) measures of brain atrophy and white matter hyperintensities (WMH).
Methods
Thirty‐seven patients with probable AD received the Neuropsychiatric Inventory (NPI), the Mini Mental Status Exam (MMSE), and an MRI scan as part of their initial evaluation at the Outpatient Memory Diagnostic Clinic at McLean Hospital. MRI‐based volumetric measurements of whole brain atrophy, hippocampal volumes, and WMH were obtained. Analysis of covariance models, using age as a covariate and the presence of specific BPSD as independent variables, were used to test for differences in whole brain volumes, hippocampal volumes and WMH volumes.
Results
Increased WMH were associated with symptoms of anxiety, aberrant motor behavior, and night time disturbance, while symptoms of disinhibition were linked to lower WMH volume. No associations were found for whole brain or hippocampal volumes and BPSD.
Conclusions
These findings suggest that white matter changes are associated with the presence of BPSD in AD. Copyright © 2009 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0885-6230</identifier><identifier>ISSN: 1099-1166</identifier><identifier>EISSN: 1099-1166</identifier><identifier>DOI: 10.1002/gps.2418</identifier><identifier>PMID: 19946864</identifier><identifier>CODEN: IJGPES</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Age ; Aged ; Aged, 80 and over ; Alzheimer Disease - diagnosis ; Alzheimer Disease - pathology ; Alzheimer Disease - psychology ; Alzheimer's disease ; Analysis of Variance ; Anxiety ; Atrophy ; behavioral and psychological symptoms of dementia ; Biological and medical sciences ; Brain ; Brain - pathology ; Brief Psychiatric Rating Scale ; Correlation analysis ; Cross-Sectional Studies ; Dementia disorders ; Female ; Fundamental and applied biological sciences. Psychology ; General aspects ; Geriatric psychiatry ; Geriatric psychology ; Geriatrics ; Hippocampus ; Hippocampus - pathology ; Hospitals ; Humans ; Inventories ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Memory ; Mental disorders ; Middle Aged ; Neurodegenerative diseases ; Neuropsychiatric Inventory ; Neuropsychological Tests ; NMR ; Nuclear magnetic resonance ; Psychoanalysis ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Retrospective Studies ; Substantia alba ; white matter hyperintensities</subject><ispartof>International journal of geriatric psychiatry, 2010-08, Vol.25 (8), p.780-788</ispartof><rights>Copyright © 2009 John Wiley & Sons, Ltd.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright John Wiley and Sons, Limited Aug 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6038-778cf3ae9751993dee15f5530a0e10022972132109cbc301daec31d281d79cb73</citedby><cites>FETCH-LOGICAL-c6038-778cf3ae9751993dee15f5530a0e10022972132109cbc301daec31d281d79cb73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fgps.2418$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fgps.2418$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23013893$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19946864$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berlow, Yosef A.</creatorcontrib><creatorcontrib>Wells, William M.</creatorcontrib><creatorcontrib>Ellison, James M.</creatorcontrib><creatorcontrib>Sung, Young Hoon</creatorcontrib><creatorcontrib>Renshaw, Perry F.</creatorcontrib><creatorcontrib>Harper, David G.</creatorcontrib><title>Neuropsychiatric correlates of white matter hyperintensities in Alzheimer's disease</title><title>International journal of geriatric psychiatry</title><addtitle>Int. J. Geriat. Psychiatry</addtitle><description>Objective
To investigate the association of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD) and magnetic resonance imaging (MRI) measures of brain atrophy and white matter hyperintensities (WMH).
Methods
Thirty‐seven patients with probable AD received the Neuropsychiatric Inventory (NPI), the Mini Mental Status Exam (MMSE), and an MRI scan as part of their initial evaluation at the Outpatient Memory Diagnostic Clinic at McLean Hospital. MRI‐based volumetric measurements of whole brain atrophy, hippocampal volumes, and WMH were obtained. Analysis of covariance models, using age as a covariate and the presence of specific BPSD as independent variables, were used to test for differences in whole brain volumes, hippocampal volumes and WMH volumes.
Results
Increased WMH were associated with symptoms of anxiety, aberrant motor behavior, and night time disturbance, while symptoms of disinhibition were linked to lower WMH volume. No associations were found for whole brain or hippocampal volumes and BPSD.
Conclusions
These findings suggest that white matter changes are associated with the presence of BPSD in AD. Copyright © 2009 John Wiley & Sons, Ltd.</description><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer Disease - psychology</subject><subject>Alzheimer's disease</subject><subject>Analysis of Variance</subject><subject>Anxiety</subject><subject>Atrophy</subject><subject>behavioral and psychological symptoms of dementia</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - pathology</subject><subject>Brief Psychiatric Rating Scale</subject><subject>Correlation analysis</subject><subject>Cross-Sectional Studies</subject><subject>Dementia disorders</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Geriatric psychiatry</subject><subject>Geriatric psychology</subject><subject>Geriatrics</subject><subject>Hippocampus</subject><subject>Hippocampus - pathology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Inventories</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory</subject><subject>Mental disorders</subject><subject>Middle Aged</subject><subject>Neurodegenerative diseases</subject><subject>Neuropsychiatric Inventory</subject><subject>Neuropsychological Tests</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Psychoanalysis</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Retrospective Studies</subject><subject>Substantia alba</subject><subject>white matter hyperintensities</subject><issn>0885-6230</issn><issn>1099-1166</issn><issn>1099-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV9rFDEUxYNY7FoFP4EMgtSXqbmTmfx5EUrRtVBXoco-hjRzp5M6OzMmGev66c3SYauC5iWQ--Pcc3IIeQb0BCgtXl-P4aQoQT4gC6BK5QCcPyQLKmWV84LRQ_I4hBtK0wzkI3IISpVc8nJBLlc4-WEMW9s6E72zmR28x85EDNnQZLeti5htTIzos3Y7ond9xD646BLg-uy0-9mi26A_DlntApqAT8hBY7qAT-f7iHx59_bz2fv84uPy_Oz0IrecMpkLIW3DDCpRJT-sRoSqqSpGDcVdqkKJAliRAtkryyjUBi2DupBQi_Qk2BF5c6c7TlcbrC320ZtOj95tjN_qwTj956R3rb4evmuWViook8DxLOCHbxOGqDcuWOw60-MwBS1KqUrKuUzkq_-SQEEokUzzhL74C70ZJt-nj9AcUiiZzr2e9UMIHpu9a6B6F16nSvWu0oQ-_z3lPTh3mICXM2CCNV3jTW9d2HOpfmBSscTld9yt63D7z4V6-elyXjzzLkT8seeN_6q5YKLS69VSL9di9UEUa83ZL0g5xxI</recordid><startdate>201008</startdate><enddate>201008</enddate><creator>Berlow, Yosef A.</creator><creator>Wells, William M.</creator><creator>Ellison, James M.</creator><creator>Sung, Young Hoon</creator><creator>Renshaw, Perry F.</creator><creator>Harper, David G.</creator><general>John Wiley & Sons, Ltd</general><general>Psychology Press</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201008</creationdate><title>Neuropsychiatric correlates of white matter hyperintensities in Alzheimer's disease</title><author>Berlow, Yosef A. ; Wells, William M. ; Ellison, James M. ; Sung, Young Hoon ; Renshaw, Perry F. ; Harper, David G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6038-778cf3ae9751993dee15f5530a0e10022972132109cbc301daec31d281d79cb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer Disease - psychology</topic><topic>Alzheimer's disease</topic><topic>Analysis of Variance</topic><topic>Anxiety</topic><topic>Atrophy</topic><topic>behavioral and psychological symptoms of dementia</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain - pathology</topic><topic>Brief Psychiatric Rating Scale</topic><topic>Correlation analysis</topic><topic>Cross-Sectional Studies</topic><topic>Dementia disorders</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>Geriatric psychiatry</topic><topic>Geriatric psychology</topic><topic>Geriatrics</topic><topic>Hippocampus</topic><topic>Hippocampus - pathology</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Inventories</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory</topic><topic>Mental disorders</topic><topic>Middle Aged</topic><topic>Neurodegenerative diseases</topic><topic>Neuropsychiatric Inventory</topic><topic>Neuropsychological Tests</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Psychoanalysis</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Retrospective Studies</topic><topic>Substantia alba</topic><topic>white matter hyperintensities</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berlow, Yosef A.</creatorcontrib><creatorcontrib>Wells, William M.</creatorcontrib><creatorcontrib>Ellison, James M.</creatorcontrib><creatorcontrib>Sung, Young Hoon</creatorcontrib><creatorcontrib>Renshaw, Perry F.</creatorcontrib><creatorcontrib>Harper, David G.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of geriatric psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berlow, Yosef A.</au><au>Wells, William M.</au><au>Ellison, James M.</au><au>Sung, Young Hoon</au><au>Renshaw, Perry F.</au><au>Harper, David G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuropsychiatric correlates of white matter hyperintensities in Alzheimer's disease</atitle><jtitle>International journal of geriatric psychiatry</jtitle><addtitle>Int. J. Geriat. Psychiatry</addtitle><date>2010-08</date><risdate>2010</risdate><volume>25</volume><issue>8</issue><spage>780</spage><epage>788</epage><pages>780-788</pages><issn>0885-6230</issn><issn>1099-1166</issn><eissn>1099-1166</eissn><coden>IJGPES</coden><abstract>Objective
To investigate the association of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD) and magnetic resonance imaging (MRI) measures of brain atrophy and white matter hyperintensities (WMH).
Methods
Thirty‐seven patients with probable AD received the Neuropsychiatric Inventory (NPI), the Mini Mental Status Exam (MMSE), and an MRI scan as part of their initial evaluation at the Outpatient Memory Diagnostic Clinic at McLean Hospital. MRI‐based volumetric measurements of whole brain atrophy, hippocampal volumes, and WMH were obtained. Analysis of covariance models, using age as a covariate and the presence of specific BPSD as independent variables, were used to test for differences in whole brain volumes, hippocampal volumes and WMH volumes.
Results
Increased WMH were associated with symptoms of anxiety, aberrant motor behavior, and night time disturbance, while symptoms of disinhibition were linked to lower WMH volume. No associations were found for whole brain or hippocampal volumes and BPSD.
Conclusions
These findings suggest that white matter changes are associated with the presence of BPSD in AD. Copyright © 2009 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>19946864</pmid><doi>10.1002/gps.2418</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Age Aged Aged, 80 and over Alzheimer Disease - diagnosis Alzheimer Disease - pathology Alzheimer Disease - psychology Alzheimer's disease Analysis of Variance Anxiety Atrophy behavioral and psychological symptoms of dementia Biological and medical sciences Brain Brain - pathology Brief Psychiatric Rating Scale Correlation analysis Cross-Sectional Studies Dementia disorders Female Fundamental and applied biological sciences. Psychology General aspects Geriatric psychiatry Geriatric psychology Geriatrics Hippocampus Hippocampus - pathology Hospitals Humans Inventories Magnetic Resonance Imaging Male Medical sciences Memory Mental disorders Middle Aged Neurodegenerative diseases Neuropsychiatric Inventory Neuropsychological Tests NMR Nuclear magnetic resonance Psychoanalysis Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Retrospective Studies Substantia alba white matter hyperintensities |
| title | Neuropsychiatric correlates of white matter hyperintensities in Alzheimer's disease |
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