Complement Protective Epitopes and CD55–Microtubule Complexes Facilitate the Invasion and Intracellular Persistence of Uropathogenic Escherichia coli

Background. Escherichia coli-bearing Dr-adhesins (Dr+ E. coli) cause chronic pyelonephritis in pregnant women and animal models. This chronic renal infection correlates with the capacity of bacteria to invade epithelial cells expressing CD55. The mechanism of infection remains unknown. Methods. CD55...

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Veröffentlicht in:	The Journal of infectious diseases 2014-04, Vol.209 (7), p.1066-1076
Hauptverfasser:	Rana, Tanu, Hasan, Rafia J., Nowicki, Stella, Venkatarajan, Mathura S., Singh, Rajbir, Urvil, Petri T., Popov, Vsevolod, Braun, Werner A., Popik, Waldemar, Goodwin, J. Shawn, Nowicki, Bogdan J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins, Escherichia coli - immunology Adhesins, Escherichia coli - metabolism Animals Bacteria Bacteriology Biological and medical sciences CD55 Antigens - genetics CD55 Antigens - metabolism CHO Cells Complement System Proteins - immunology Cricetulus Endocytosis Epithelial cells Epitopes Escherichia coli Fundamental and applied biological sciences. Psychology Infections Infectious diseases Major and Brief Reports Medical sciences Microbiology Microscopy Microscopy, Confocal Microscopy, Electron Microtubules - metabolism Miscellaneous Mutant Proteins - genetics Mutant Proteins - metabolism Ovaries Protein Conformation Pyelonephritis Uropathogenic Escherichia coli - immunology Uropathogenic Escherichia coli - physiology Vacuoles
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