A porous tissue engineering scaffold selectively degraded by cell-generated reactive oxygen species

Abstract Biodegradable tissue engineering scaffolds are commonly fabricated from poly(lactide-co-glycolide) (PLGA) or similar polyesters that degrade by hydrolysis. PLGA hydrolysis generates acidic breakdown products that trigger an accelerated, autocatalytic degradation mechanism that can create mi...

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Veröffentlicht in:	Biomaterials 2014-04, Vol.35 (12), p.3766-3776
Hauptverfasser:	Martin, John R, Gupta, Mukesh K, Page, Jonathan M, Yu, Fang, Davidson, Jeffrey M, Guelcher, Scott A, Duvall, Craig L
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals biobased products Biocompatible Materials biodegradability Biodegradation Catalysis Dentistry glycols granulation tissue hydrolysis inflammation Lactic Acid - chemistry Macrophage Microscopy, Electron, Scanning Oxidation polyesters Polyglycolic Acid - chemistry Polyurethane Porosity Rats reactive oxygen species Reactive Oxygen Species - metabolism Scaffold Tissue Engineering Tissue Scaffolds urethane Wound healing Wounds and Injuries - therapy
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