Myocilin Regulates Cell Proliferation and Survival

Myocilin, a causative gene for open angle glaucoma, encodes a secreted glycoprotein with poorly understood functions. To gain insight into its functions, we produced a stably transfected HEK293 cell line expressing myocilin under an inducible promoter and compared gene expression profiles between my...

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Veröffentlicht in:	The Journal of biological chemistry 2014-04, Vol.289 (14), p.10155-10167
Hauptverfasser:	Joe, Myung Kuk, Kwon, Heung Sun, Cojocaru, Radu, Tomarev, Stanislav I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - physiology Caspase 7 - genetics Caspase 7 - metabolism Cell Biology Cell Growth Cell Proliferation Cell Signaling Cell Survival - physiology Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism ERK Eye Proteins - genetics Eye Proteins - metabolism Glycoproteins - genetics Glycoproteins - metabolism HEK293 Cells Humans MAP Kinase Signaling System - physiology Mesenchymal Stem Cells Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Mice Mice, Transgenic Mitogen-Activated Protein Kinase 1 - genetics Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 3 - metabolism Phosphorylation - physiology
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