Cadmium Exposure and Liver Disease among US Adults
Background Effects of chronic cadmium exposure on liver disease and liver-related mortality are unknown. We evaluated the association of creatinine-corrected urinary cadmium levels with hepatic necroinflammation, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), liver-...
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| Veröffentlicht in: | Journal of gastrointestinal surgery 2013-07, Vol.17 (7), p.1265-1273 |
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| creator | Hyder, Omar Chung, Michael Cosgrove, David Herman, Joseph M. Li, Zhiping Firoozmand, Amin Gurakar, Ahmet Koteish, Ayman Pawlik, Timothy M. |
| description | Background
Effects of chronic cadmium exposure on liver disease and liver-related mortality are unknown. We evaluated the association of creatinine-corrected urinary cadmium levels with hepatic necroinflammation, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), liver-related mortality, and liver cancer mortality in the US general population.
Methods
We analyzed the relationship of individuals in the top quartile for urinary cadmium measured in 12,732 adults who participated in the Third National Health and Nutrition Examination Survey in 1988–1994 (NHANES III), and hepatic necroinflammation, NAFLD, and NASH. Associations between cadmium, liver-related mortality, and liver cancer mortality were evaluated in the NHANES III mortality follow-up study.
Results
The cutoffs for highest quartile of urinary cadmium per gram of urinary creatinine were 0.65 and 0.83 μg/g for men and women, respectively (
P
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| doi_str_mv | 10.1007/s11605-013-2210-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3974907</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2988638541</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-c8eeedba424ba0628ee2ae690bec2fad41c6ba0887dde61203fdd6c80868ac493</originalsourceid><addsrcrecordid>eNp1kEtLAzEUhYMotlZ_gBsZcD16k0nz2Ail1gcUXGjBXcgkaZ3SmanJTNF_b8rUUheuktxzcu7hQ-gSww0G4LcBYwbDFHCWEoIhlUeojwXPUsoIO453kDglw-F7D52FsATAHLA4RT2SsYwJgfuIjLUti7ZMJl_rOrTeJbqyybTYOJ_cF8HpECdlXS2S2Wsysu2qCefoZK5XwV3szgGaPUzexk_p9OXxeTyapoZyaFIjnHM215TQXAMj8Um0YxJyZ8hcW4oNi4IQ3FrHMIFsbi0zAgQT2lCZDdBdl7tu89JZ46rG65Va-6LU_lvVulB_lar4UIt6ozLJqQQeA653Ab7-bF1o1LJufRU7K5wxKqWQnEUX7lzG1yF4N99vwKC2mFWHWUXMaotZbatdHVbb__jlGg2kM4QoVQvnD1b_m_oDA56IiQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1364998976</pqid></control><display><type>article</type><title>Cadmium Exposure and Liver Disease among US Adults</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Hyder, Omar ; Chung, Michael ; Cosgrove, David ; Herman, Joseph M. ; Li, Zhiping ; Firoozmand, Amin ; Gurakar, Ahmet ; Koteish, Ayman ; Pawlik, Timothy M.</creator><creatorcontrib>Hyder, Omar ; Chung, Michael ; Cosgrove, David ; Herman, Joseph M. ; Li, Zhiping ; Firoozmand, Amin ; Gurakar, Ahmet ; Koteish, Ayman ; Pawlik, Timothy M.</creatorcontrib><description>Background
Effects of chronic cadmium exposure on liver disease and liver-related mortality are unknown. We evaluated the association of creatinine-corrected urinary cadmium levels with hepatic necroinflammation, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), liver-related mortality, and liver cancer mortality in the US general population.
Methods
We analyzed the relationship of individuals in the top quartile for urinary cadmium measured in 12,732 adults who participated in the Third National Health and Nutrition Examination Survey in 1988–1994 (NHANES III), and hepatic necroinflammation, NAFLD, and NASH. Associations between cadmium, liver-related mortality, and liver cancer mortality were evaluated in the NHANES III mortality follow-up study.
Results
The cutoffs for highest quartile of urinary cadmium per gram of urinary creatinine were 0.65 and 0.83 μg/g for men and women, respectively (
P
< 0.001). After multivariate adjustment for other factors including smoking, the odds ratios [95 % confidence intervals (CI)] for hepatic necroinflammation, NAFLD, and NASH associated with being in the top quartile of cadmium levels by gender, were 2.21 (95 % CI, 1.64–3.00), 1.30 (95 % CI, 1.01–1.68) and 1.95 (95 % CI, 1.11–3.41) for men and 1.26 (95 % CI, 1.01–1.57), 1.11 (95 % CI, 0.88–1.41) and 1.34 (95 % CI, 0.72–2.50) for women, respectively. The hazard ratios for liver-related mortality and liver cancer mortality for both genders were 3.42 (95 % CI, 1.12–10.47) and 1.25 (95 % CI, 0.37–4.27).
Conclusions
Environmental cadmium exposure was associated with hepatic necroinflammation, NAFLD, and NASH in men, and hepatic necroinflammation in women. Individuals in the top quartile of creatinine-corrected urinary cadmium had over a threefold increased risk of liver disease mortality but not in liver cancer related mortality.</description><identifier>ISSN: 1091-255X</identifier><identifier>EISSN: 1873-4626</identifier><identifier>DOI: 10.1007/s11605-013-2210-9</identifier><identifier>PMID: 23636881</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Adult ; Automation ; Body mass index ; Cadmium ; Cadmium - toxicity ; Chemical and Drug Induced Liver Injury - etiology ; Chemical and Drug Induced Liver Injury - mortality ; Chemical and Drug Induced Liver Injury - pathology ; Creatinine ; Environmental Exposure - adverse effects ; Fatty Liver - chemically induced ; Fatty Liver - mortality ; Female ; Gastroenterology ; Hepatitis ; Humans ; Laboratories ; Liver - pathology ; Liver cancer ; Liver diseases ; Liver Neoplasms - mortality ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Missing data ; Mortality ; Necrosis - chemically induced ; Non-alcoholic Fatty Liver Disease ; Nutrition ; Oncology ; Original Article ; Population ; Smoking ; Surgery ; United States - epidemiology ; Womens health</subject><ispartof>Journal of gastrointestinal surgery, 2013-07, Vol.17 (7), p.1265-1273</ispartof><rights>The Society for Surgery of the Alimentary Tract 2013</rights><rights>2013 The Society for Surgery of the Alimentary Tract 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-c8eeedba424ba0628ee2ae690bec2fad41c6ba0887dde61203fdd6c80868ac493</citedby><cites>FETCH-LOGICAL-c470t-c8eeedba424ba0628ee2ae690bec2fad41c6ba0887dde61203fdd6c80868ac493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11605-013-2210-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11605-013-2210-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23636881$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hyder, Omar</creatorcontrib><creatorcontrib>Chung, Michael</creatorcontrib><creatorcontrib>Cosgrove, David</creatorcontrib><creatorcontrib>Herman, Joseph M.</creatorcontrib><creatorcontrib>Li, Zhiping</creatorcontrib><creatorcontrib>Firoozmand, Amin</creatorcontrib><creatorcontrib>Gurakar, Ahmet</creatorcontrib><creatorcontrib>Koteish, Ayman</creatorcontrib><creatorcontrib>Pawlik, Timothy M.</creatorcontrib><title>Cadmium Exposure and Liver Disease among US Adults</title><title>Journal of gastrointestinal surgery</title><addtitle>J Gastrointest Surg</addtitle><addtitle>J Gastrointest Surg</addtitle><description>Background
Effects of chronic cadmium exposure on liver disease and liver-related mortality are unknown. We evaluated the association of creatinine-corrected urinary cadmium levels with hepatic necroinflammation, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), liver-related mortality, and liver cancer mortality in the US general population.
Methods
We analyzed the relationship of individuals in the top quartile for urinary cadmium measured in 12,732 adults who participated in the Third National Health and Nutrition Examination Survey in 1988–1994 (NHANES III), and hepatic necroinflammation, NAFLD, and NASH. Associations between cadmium, liver-related mortality, and liver cancer mortality were evaluated in the NHANES III mortality follow-up study.
Results
The cutoffs for highest quartile of urinary cadmium per gram of urinary creatinine were 0.65 and 0.83 μg/g for men and women, respectively (
P
< 0.001). After multivariate adjustment for other factors including smoking, the odds ratios [95 % confidence intervals (CI)] for hepatic necroinflammation, NAFLD, and NASH associated with being in the top quartile of cadmium levels by gender, were 2.21 (95 % CI, 1.64–3.00), 1.30 (95 % CI, 1.01–1.68) and 1.95 (95 % CI, 1.11–3.41) for men and 1.26 (95 % CI, 1.01–1.57), 1.11 (95 % CI, 0.88–1.41) and 1.34 (95 % CI, 0.72–2.50) for women, respectively. The hazard ratios for liver-related mortality and liver cancer mortality for both genders were 3.42 (95 % CI, 1.12–10.47) and 1.25 (95 % CI, 0.37–4.27).
Conclusions
Environmental cadmium exposure was associated with hepatic necroinflammation, NAFLD, and NASH in men, and hepatic necroinflammation in women. Individuals in the top quartile of creatinine-corrected urinary cadmium had over a threefold increased risk of liver disease mortality but not in liver cancer related mortality.</description><subject>Adult</subject><subject>Automation</subject><subject>Body mass index</subject><subject>Cadmium</subject><subject>Cadmium - toxicity</subject><subject>Chemical and Drug Induced Liver Injury - etiology</subject><subject>Chemical and Drug Induced Liver Injury - mortality</subject><subject>Chemical and Drug Induced Liver Injury - pathology</subject><subject>Creatinine</subject><subject>Environmental Exposure - adverse effects</subject><subject>Fatty Liver - chemically induced</subject><subject>Fatty Liver - mortality</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Hepatitis</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Liver - pathology</subject><subject>Liver cancer</subject><subject>Liver diseases</subject><subject>Liver Neoplasms - mortality</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Missing data</subject><subject>Mortality</subject><subject>Necrosis - chemically induced</subject><subject>Non-alcoholic Fatty Liver Disease</subject><subject>Nutrition</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Population</subject><subject>Smoking</subject><subject>Surgery</subject><subject>United States - epidemiology</subject><subject>Womens health</subject><issn>1091-255X</issn><issn>1873-4626</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kEtLAzEUhYMotlZ_gBsZcD16k0nz2Ail1gcUXGjBXcgkaZ3SmanJTNF_b8rUUheuktxzcu7hQ-gSww0G4LcBYwbDFHCWEoIhlUeojwXPUsoIO453kDglw-F7D52FsATAHLA4RT2SsYwJgfuIjLUti7ZMJl_rOrTeJbqyybTYOJ_cF8HpECdlXS2S2Wsysu2qCefoZK5XwV3szgGaPUzexk_p9OXxeTyapoZyaFIjnHM215TQXAMj8Um0YxJyZ8hcW4oNi4IQ3FrHMIFsbi0zAgQT2lCZDdBdl7tu89JZ46rG65Va-6LU_lvVulB_lar4UIt6ozLJqQQeA653Ab7-bF1o1LJufRU7K5wxKqWQnEUX7lzG1yF4N99vwKC2mFWHWUXMaotZbatdHVbb__jlGg2kM4QoVQvnD1b_m_oDA56IiQ</recordid><startdate>20130701</startdate><enddate>20130701</enddate><creator>Hyder, Omar</creator><creator>Chung, Michael</creator><creator>Cosgrove, David</creator><creator>Herman, Joseph M.</creator><creator>Li, Zhiping</creator><creator>Firoozmand, Amin</creator><creator>Gurakar, Ahmet</creator><creator>Koteish, Ayman</creator><creator>Pawlik, Timothy M.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20130701</creationdate><title>Cadmium Exposure and Liver Disease among US Adults</title><author>Hyder, Omar ; Chung, Michael ; Cosgrove, David ; Herman, Joseph M. ; Li, Zhiping ; Firoozmand, Amin ; Gurakar, Ahmet ; Koteish, Ayman ; Pawlik, Timothy M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-c8eeedba424ba0628ee2ae690bec2fad41c6ba0887dde61203fdd6c80868ac493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Automation</topic><topic>Body mass index</topic><topic>Cadmium</topic><topic>Cadmium - toxicity</topic><topic>Chemical and Drug Induced Liver Injury - etiology</topic><topic>Chemical and Drug Induced Liver Injury - mortality</topic><topic>Chemical and Drug Induced Liver Injury - pathology</topic><topic>Creatinine</topic><topic>Environmental Exposure - adverse effects</topic><topic>Fatty Liver - chemically induced</topic><topic>Fatty Liver - mortality</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Hepatitis</topic><topic>Humans</topic><topic>Laboratories</topic><topic>Liver - pathology</topic><topic>Liver cancer</topic><topic>Liver diseases</topic><topic>Liver Neoplasms - mortality</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Missing data</topic><topic>Mortality</topic><topic>Necrosis - chemically induced</topic><topic>Non-alcoholic Fatty Liver Disease</topic><topic>Nutrition</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Population</topic><topic>Smoking</topic><topic>Surgery</topic><topic>United States - epidemiology</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hyder, Omar</creatorcontrib><creatorcontrib>Chung, Michael</creatorcontrib><creatorcontrib>Cosgrove, David</creatorcontrib><creatorcontrib>Herman, Joseph M.</creatorcontrib><creatorcontrib>Li, Zhiping</creatorcontrib><creatorcontrib>Firoozmand, Amin</creatorcontrib><creatorcontrib>Gurakar, Ahmet</creatorcontrib><creatorcontrib>Koteish, Ayman</creatorcontrib><creatorcontrib>Pawlik, Timothy M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of gastrointestinal surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hyder, Omar</au><au>Chung, Michael</au><au>Cosgrove, David</au><au>Herman, Joseph M.</au><au>Li, Zhiping</au><au>Firoozmand, Amin</au><au>Gurakar, Ahmet</au><au>Koteish, Ayman</au><au>Pawlik, Timothy M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cadmium Exposure and Liver Disease among US Adults</atitle><jtitle>Journal of gastrointestinal surgery</jtitle><stitle>J Gastrointest Surg</stitle><addtitle>J Gastrointest Surg</addtitle><date>2013-07-01</date><risdate>2013</risdate><volume>17</volume><issue>7</issue><spage>1265</spage><epage>1273</epage><pages>1265-1273</pages><issn>1091-255X</issn><eissn>1873-4626</eissn><abstract>Background
Effects of chronic cadmium exposure on liver disease and liver-related mortality are unknown. We evaluated the association of creatinine-corrected urinary cadmium levels with hepatic necroinflammation, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), liver-related mortality, and liver cancer mortality in the US general population.
Methods
We analyzed the relationship of individuals in the top quartile for urinary cadmium measured in 12,732 adults who participated in the Third National Health and Nutrition Examination Survey in 1988–1994 (NHANES III), and hepatic necroinflammation, NAFLD, and NASH. Associations between cadmium, liver-related mortality, and liver cancer mortality were evaluated in the NHANES III mortality follow-up study.
Results
The cutoffs for highest quartile of urinary cadmium per gram of urinary creatinine were 0.65 and 0.83 μg/g for men and women, respectively (
P
< 0.001). After multivariate adjustment for other factors including smoking, the odds ratios [95 % confidence intervals (CI)] for hepatic necroinflammation, NAFLD, and NASH associated with being in the top quartile of cadmium levels by gender, were 2.21 (95 % CI, 1.64–3.00), 1.30 (95 % CI, 1.01–1.68) and 1.95 (95 % CI, 1.11–3.41) for men and 1.26 (95 % CI, 1.01–1.57), 1.11 (95 % CI, 0.88–1.41) and 1.34 (95 % CI, 0.72–2.50) for women, respectively. The hazard ratios for liver-related mortality and liver cancer mortality for both genders were 3.42 (95 % CI, 1.12–10.47) and 1.25 (95 % CI, 0.37–4.27).
Conclusions
Environmental cadmium exposure was associated with hepatic necroinflammation, NAFLD, and NASH in men, and hepatic necroinflammation in women. Individuals in the top quartile of creatinine-corrected urinary cadmium had over a threefold increased risk of liver disease mortality but not in liver cancer related mortality.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>23636881</pmid><doi>10.1007/s11605-013-2210-9</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Automation Body mass index Cadmium Cadmium - toxicity Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - mortality Chemical and Drug Induced Liver Injury - pathology Creatinine Environmental Exposure - adverse effects Fatty Liver - chemically induced Fatty Liver - mortality Female Gastroenterology Hepatitis Humans Laboratories Liver - pathology Liver cancer Liver diseases Liver Neoplasms - mortality Male Medicine Medicine & Public Health Middle Aged Missing data Mortality Necrosis - chemically induced Non-alcoholic Fatty Liver Disease Nutrition Oncology Original Article Population Smoking Surgery United States - epidemiology Womens health |
| title | Cadmium Exposure and Liver Disease among US Adults |
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