Characterizing the Microstructure of Heparin and Heparan Sulfate Using N‑Sulfoglucosamine 1H and 15N NMR Chemical Shift Analysis

Heparin and heparan sulfate (HS) are members of a biologically important group of highly anionic linear polysaccharides called glycosaminoglycans (GAGs). Because of their structural complexity, the molecular-level characterization of heparin and HS continues to be a challenge. The work presented her...

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Veröffentlicht in:	Analytical chemistry (Washington) 2013-01, Vol.85 (2), p.1247-1255
Hauptverfasser:	Langeslay, Derek J, Beecher, Consuelo N, Naggi, Annamaria, Guerrini, Marco, Torri, Giangiacomo, Larive, Cynthia K
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbohydrate Conformation Cells, Cultured enoxaparin Glucosamine - analogs & derivatives Glucosamine - chemistry HEK293 Cells heparan sulfate Heparin - chemistry Heparitin Sulfate - chemistry Heparitin Sulfate - isolation & purification Humans Magnetic Resonance Spectroscopy - standards microstructure molecular weight nitrogen Nitrogen Isotopes nuclear magnetic resonance spectroscopy oligosaccharides Protons Reference Standards stable isotopes swine
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