Mapping Polymerization and Allostery of Hemoglobin S Using Point Mutations

Hemoglobin is a complex system that undergoes conformational changes in response to oxygen, allosteric effectors, mutations, and environmental changes. Here, we study allostery and polymerization of hemoglobin and its variants by application of two previously described methods: (i) AllosMod for simu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The journal of physical chemistry. B 2013-10, Vol.117 (42), p.13058-13068
Hauptverfasser:	Weinkam, Patrick, Sali, Andrej
Format:	Artikel
Sprache:	eng
Schlagworte:	2,3-Diphosphoglycerate - chemistry 2,3-Diphosphoglycerate - metabolism abnormal hemoglobin Allosteric Regulation artificial intelligence Binding Binding Sites Biological and medical sciences crystal structure Dynamics Entropy Fundamental and applied biological sciences. Psychology Hemoglobin Hemoglobin, Sickle - chemistry Hemoglobin, Sickle - genetics Hemoglobin, Sickle - metabolism Humans Mathematical models Molecular biophysics Mutations oxygen Oxygen - chemistry Oxygen - metabolism Pocket Point Mutation Polymerization prediction Protein Binding Protein Structure, Tertiary Structure in molecular biology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!